Benzo[a]pyrene immunogenetics and immune archetype reprogramming of lung.
Benzo[a]pyrene
Immune modulation
Lung cancer
TGF-β
Treg
Journal
Toxicology
ISSN: 1879-3185
Titre abrégé: Toxicology
Pays: Ireland
ID NLM: 0361055
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
18
08
2021
revised:
16
10
2021
accepted:
18
10
2021
pubmed:
23
10
2021
medline:
29
12
2021
entrez:
22
10
2021
Statut:
ppublish
Résumé
Overexposure to carcinogenic precursor, benzo[a]pyrene [BaP], modulates the lung immune microenvironment. The present review seeks to elucidate novel pathways behind the tumor effect of BaP in the lungs, emphasizing immunomodulatory mediators and immune cells. In this review, BaP reprograms lung immune microenvironment through modulating transforming growth factor-beta (TGF-β), programmed cell death 1 (PD-1), cytotoxic T lymphocyte antigen-4 (CTLA-4), Interleukin 12 (IL-12), indoleamine 2,3 dioxygenase (IDO), forkhead box protein P3 (FOXP3) and interferon-gamma (IFN-γ) levels. Moreover, BaP modulated lung immune cellular architecture such as dendritic cells, T cells, Tregs, macrophages, neutrophils, and myeloid-derived suppressor cells (MDSCs). All mentioned changes in immune architecture and mediators lead to the induction of lung cancer.
Identifiants
pubmed: 34678320
pii: S0300-483X(21)00316-4
doi: 10.1016/j.tox.2021.152994
pii:
doi:
Substances chimiques
Carcinogens
0
Benzo(a)pyrene
3417WMA06D
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
152994Informations de copyright
Copyright © 2021. Published by Elsevier B.V.