D-dimer levels for Risk Stratification in Patients with Suspected COVID-19 - A Prospective Observational Study.

COVID-19 Female Fibrin Fibrinogen Degradation Products Humans Male Middle Aged Risk Assessment SARS-CoV-2

Journal

Acute medicine
ISSN: 1747-4892
Titre abrégé: Acute Med
Pays: England
ID NLM: 101553725

Informations de publication

Date de publication:
2021
Historique:
entrez: 22 10 2021
pubmed: 23 10 2021
medline: 27 10 2021
Statut: ppublish

Résumé

Elevated D-dimer levels have been observed in COVID-19 and are of prognostic value, but have not been compared to an appropriate control group. Observational cohort study including emergency patients with suspected or confirmed COVID-19. Logistic regression defined the association of D-dimer levels, COVID-19 positivity, age, and gender with 30-day-mortality. 953 consecutive patients (median age 58, 43% women) presented with suspected COVID-19: 12 (7.4%) patients with confirmed SARS-CoV-2-infection died, compared with 28 (3.5%) patients without SARS-CoV-2-infection. Overall, most (56%) patients had elevated D-dimer levels (≥0.5mg/l). Age (OR 1.07, CI 1.05-1.10), D-dimer levels ≥0.5mg/l (OR 2.44, CI 0.98-7.39), and COVID-19 (OR 2.79, CI 1.28-5.80) were associated with 30-day-mortality. D-dimer levels are effective prognosticators in both patient groups.

Sections du résumé

BACKGROUND BACKGROUND
Elevated D-dimer levels have been observed in COVID-19 and are of prognostic value, but have not been compared to an appropriate control group.
METHODS METHODS
Observational cohort study including emergency patients with suspected or confirmed COVID-19. Logistic regression defined the association of D-dimer levels, COVID-19 positivity, age, and gender with 30-day-mortality.
RESULTS RESULTS
953 consecutive patients (median age 58, 43% women) presented with suspected COVID-19: 12 (7.4%) patients with confirmed SARS-CoV-2-infection died, compared with 28 (3.5%) patients without SARS-CoV-2-infection. Overall, most (56%) patients had elevated D-dimer levels (≥0.5mg/l). Age (OR 1.07, CI 1.05-1.10), D-dimer levels ≥0.5mg/l (OR 2.44, CI 0.98-7.39), and COVID-19 (OR 2.79, CI 1.28-5.80) were associated with 30-day-mortality.
CONCLUSION CONCLUSIONS
D-dimer levels are effective prognosticators in both patient groups.

Identifiants

PMID: 34679137
pubmed: 34679137

Substances chimiques

Fibrin Fibrinogen Degradation Products 0
fibrin fragment D 0

Types de publication

Journal Article Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

193-203

Auteurs

A S Jauslin (AS)

MD, Emergency Department, University Hospital Basel, 4031 Basel, Switzerland.

J Kellett (J)

MD, Department of Emergency Medicine, Hospital of South West Jutland, 6700 Esbjerg, Denmark.

M Brabrand (M)

MD, PhD, Department of Emergency Medicine, Hospital of South West Jutland, 6700 Esbjerg, Denmark.

N R Simon (NR)

MD, Emergency Department, University Hospital Basel, 4031 Basel, Switzerland.

M Rueegg (M)

MD, Emergency Department, University Hospital Basel, 4031 Basel, Switzerland.

R Twerenbold (R)

MD, Department of Cardiology, University Hospital Basel, 4031 Basel, Switzerland.

S Osswald (S)

MD, Department of Cardiology, University Hospital Basel, 4031 Basel, Switzerland.

S Bassetti (S)

MD, Department of Internal Medicine, University Hospital Basel, 4031 Basel, Switzerland.

S Tschudin-Sutter (S)

MD, Division of Infectious Disease & Hospital Epidemiology, University Hospital Basel, 4031 Basel, Switzerland.

M Siegemund (M)

MD, Department of Intensive Care, University Hospital Basel, 4031 Basel, Switzerland.

K Rentsch (K)

PhD, Department of Laboratory Medicine, University Hospital Basel, 4031 Basel, Switzerland.

R Bingisser (R)

MD, Emergency Department, University Hospital Basel, 4031 Basel, Switzerland.

C H Nickel (CH)

MD, Emergency Department, University Hospital Basel, 4031 Basel, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › D-dimer levels for Risk Stratification in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Précurseurs de protéines › Produits de dégradation de la fibrine et du fibrinogène › D-dimer levels for Risk Stratification in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › D-dimer levels for Risk Stratification in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › D-dimer levels for Risk Stratification in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Appréciation des risques › D-dimer levels for Risk Stratification in...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › D-dimer levels for Risk Stratification in...