Prevalence and determinants of depression up to 5 years after colorectal cancer surgery: results from the ColoREctal Wellbeing (CREW) study.
colorectal cancer
depression
determinants
quality of life
risk factors
Journal
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
ISSN: 1463-1318
Titre abrégé: Colorectal Dis
Pays: England
ID NLM: 100883611
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
03
06
2021
received:
24
03
2021
accepted:
17
06
2021
pubmed:
23
10
2021
medline:
29
1
2022
entrez:
22
10
2021
Statut:
ppublish
Résumé
Depression experienced by people with colorectal cancer (CRC) is an important clinical problem affecting quality of life. Recognition of depression at key points in the pathway enables timely referral to support. This study aimed to examine depression before and 5 years after surgery to examine its prevalence and identify determinants. The ColoREctal Wellbeing (CREW) study is a prospective UK cohort study involving 872 adults with nonmetastatic CRC recruited before surgery with curative intent. Questionnaires completed before surgery and 3, 9, 15, 24, 36, 48 and 60 months after surgery captured socio-demographics and assessed depression (Centre for Epidemiologic Studies Depression Scale, CES-D) and other psychosocial factors. Clinical details were also gathered. We present the prevalence of clinically significant depression (CES-D ≥ 20) over time and its predictors assessed before and 2 years after surgery. Before surgery, 21.0% of the cohort reported CES-D ≥ 20 reducing to 14.7% 5 years after surgery. Presurgery risk factors predicting subsequent depression were clinically significant depression and anxiety, previous mental health service use, low self-efficacy, poor health, having neoadjuvant treatment and low social support. Postsurgery risk factors at 2 years predicting subsequent depression were clinically significant depression, negative affect, cognitive dysfunction, accommodation type and poor health. Depression is highly pervasive in people with CRC, exceeding prevalence in the general population across follow-up. Our findings emphasize the need to screen and treat depression across the pathway. Our novel data highlight key risk factors of later depression at important and opportune time points: before surgery and at the end of routine surveillance. Early recognition and timely referral to appropriate support is vital to improve long-term psychological outcomes.
Identifiants
pubmed: 34679253
doi: 10.1111/codi.15949
pmc: PMC9298990
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3234-3250Subventions
Organisme : Macmillan Cancer Support
ID : 3546834
Investigateurs
Jo Armes
(J)
Janis Baird
(J)
Andrew Bateman
(A)
Nick Beck
(N)
Graham Moon
(G)
Claire Hulme
(C)
Peter Hall
(P)
Karen Poole
(K)
Susan Restorick-Banks
(S)
Paul Roderick
(P)
Claire Taylor
(C)
Jocelyn Walters
(J)
Fran Williams
(F)
Lynn Batehup
(L)
Jessica Corner
(J)
Deborah Fenlon
(D)
Informations de copyright
© 2021 The Authors. Colorectal Disease published by John Wiley & Sons Ltd on behalf of Association of Coloproctology of Great Britain and Ireland.
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