Arq Ajīb - a wonder Unani formulation for inhibiting SARS-CoV-2 spike glycoprotein and main protease - an
Arq Ajīb
SARS-CoV-2
isorhoifolin
molecular docking
quercetin
Journal
Journal of complementary & integrative medicine
ISSN: 1553-3840
Titre abrégé: J Complement Integr Med
Pays: Germany
ID NLM: 101313855
Informations de publication
Date de publication:
01 Sep 2023
01 Sep 2023
Historique:
received:
05
06
2021
accepted:
06
10
2021
medline:
23
10
2021
pubmed:
23
10
2021
entrez:
22
10
2021
Statut:
epublish
Résumé
The current pandemic caused by Severe Acute Respiratory Syndrome Corona-Virus 2 (SARS-CoV-2) has become a global health menace with significant morbidity and mortality besides huge socioeconomic implications. Despite the approval of few vaccines for the prevention of the disease, the discovery of safe and effective countermeasures especially from natural sources is of paramount importance, as the number of cases continues escalating. Arq Ajīb has long been used for various diseases and its ingredients have been reported for antiviral, antimicrobial, antipyretic, anti-inflammatory, antioxidant activities. The present study investigates the inhibitory effect of phytocompound of Arq Ajīb on potential drug targets of SARS-CoV-2. The structures of phytocompounds present in Arq Ajīb were retrieved from PubChem database and some were illustrated using Marvin Sketch. SARS-CoV-2 S glycoprotein (PDB ID: 6LZG) and 3CL Molecular docking results predicted that the phytocompounds of Arq Ajīb had good binding affinity and interaction with S glycoprotein and 3CL Arq Ajīb may prove valuable for developing novel therapeutic candidate for COVID-19; however, it has to be substantiated further with
Identifiants
pubmed: 34679263
pii: jcim-2021-0241
doi: 10.1515/jcim-2021-0241
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
637-649Informations de copyright
© 2021 Walter de Gruyter GmbH, Berlin/Boston.
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