Potential Role of Hydroxyapatite Nanocrystalline for Early Diagnostics of Ovarian Cancer.
calcification
early diagnostics
hydroxyapatite
ovarian cancer
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
22 Sep 2021
22 Sep 2021
Historique:
received:
12
08
2021
revised:
08
09
2021
accepted:
16
09
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
24
10
2021
Statut:
epublish
Résumé
Calcification is one of the clinical and morphological manifestations of ovarian tumors and it begins at the initial stages of carcinogenesis. Thus, this process can be used for the early diagnostics of some malignant ovarian tumors. We compared the results of ultrasound and histology and found that calcifications of a size less than 200 μm are not detected by ultrasound. These calcified structures are round fragile particles of different sizes. In the EDX (Energy-dispersive X-ray spectroscopy) spectra, the main lines were from Ca and P, and the ratio of these elements corresponds to hydroxyapatite. Thus, we established that hydroxyapatite is the main mineral component of ovarian psammoma bodies and could be used for early diagnostics of ovarian malignant neoplasia.
Identifiants
pubmed: 34679439
pii: diagnostics11101741
doi: 10.3390/diagnostics11101741
pmc: PMC8534774
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Education and Science of Ukraine
ID : No. 0112U100471
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