Discovering the Molecular Landscape of Meningioma: The Struggle to Find New Therapeutic Targets.
DNA methylation
NF2
SMO
meningioma
molecular alterations
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
08 Oct 2021
08 Oct 2021
Historique:
received:
24
07
2021
revised:
27
09
2021
accepted:
04
10
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
24
10
2021
Statut:
epublish
Résumé
Meningiomas are the most common primary CNS tumors. They are usually benign but can present aggressive behavior in about 20% of cases. The genetic landscape of meningioma is characterized by the presence (in about 60% of cases) or absence of NF2 mutation. Low-grade meningiomas can also present other genetic alterations, particularly affecting SMO, TRAF7, KLF4 AKT1 and PI3KCA. In higher grade meningiomas, mutations of TERT promoter and deletion of CDKN2A/B seem to have a prognostic value. Furthermore, other genetic alterations have been identified, such as BAP1, DMD and PBRM1. Different subgroups of DNA methylation appear to be correlated with prognosis. In this review, we explored the genetic landscape of meningiomas and the possible therapeutic implications.
Identifiants
pubmed: 34679551
pii: diagnostics11101852
doi: 10.3390/diagnostics11101852
pmc: PMC8534341
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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