Shortening Epitopes to Survive: The Case of SARS-CoV-2 Lambda Variant.
Lambda variant
N-glycosylation site
SARS-CoV-2
epitope loop shortening
immunoevasion
interaction energy
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
10 10 2021
10 10 2021
Historique:
received:
03
09
2021
revised:
06
10
2021
accepted:
07
10
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
3
11
2021
Statut:
epublish
Résumé
Among the more recently identified SARS-CoV-2 Variants of Interest (VOI) is the Lambda variant, which emerged in Peru and has rapidly spread to South American regions and the US. This variant remains poorly investigated, particularly regarding the effects of mutations on the thermodynamic parameters affecting the stability of the Spike protein and its Receptor Binding Domain. We report here an in silico study on the potential impact of the Spike protein mutations on the immuno-escape ability of the Lambda variant. Bioinformatics analysis suggests that a combination of shortening the immunogenic epitope loops and the generation of potential N-glycosylation sites may be a viable adaptation strategy, potentially allowing this emerging viral variant to escape from host immunity.
Identifiants
pubmed: 34680128
pii: biom11101494
doi: 10.3390/biom11101494
pmc: PMC8533401
pii:
doi:
Substances chimiques
Epitopes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Sapienza University of Rome
ID : RP120172B49BE241
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