The Dual Role of Innate Lymphoid and Natural Killer Cells in Cancer. from Phenotype to Single-Cell Transcriptomics, Functions and Clinical Uses.
biomarker
blood immune cells
gene profiling
immunomonitoring
immunotherapy
scRNA-seq
single-cell RNA sequencing
single-cell transcriptomics
therapy resistance
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
09 Oct 2021
09 Oct 2021
Historique:
received:
30
08
2021
revised:
05
10
2021
accepted:
06
10
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
24
10
2021
Statut:
epublish
Résumé
The role of innate lymphoid cells (ILCs), including natural killer (NK) cells, is pivotal in inflammatory modulation and cancer. Natural killer cell activity and count have been demonstrated to be regulated by the expression of activating and inhibitory receptors together with and as a consequence of different stimuli. The great majority of NK cell populations have an anti-tumor activity due to their cytotoxicity, and for this reason have been used for cellular therapies in cancer patients. On the other hand, the recently classified helper ILCs are fundamentally involved in inflammation and they can be either helpful or harmful in cancer development and progression. Tissue niche seems to play an important role in modulating ILC function and conversion, as observed at the transcriptional level. In the past, these cell populations have been classified by the presence of specific cellular receptor markers; more recently, due to the advent of single-cell RNA sequencing (scRNA-seq), it has been possible to also explore them at the transcriptomic level. In this article we review studies on ILC (and NK cell) classification, function and their involvement in cancer. We also summarize the potential application of NK cells in cancer therapy and give an overview of the most recent studies involving ILCs and NKs at scRNA-seq, focusing on cancer. Finally, we provide a resource for those who wish to start single-cell transcriptomic analysis on the context of these innate lymphoid cell populations.
Identifiants
pubmed: 34680190
pii: cancers13205042
doi: 10.3390/cancers13205042
pmc: PMC8533946
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG20109
Références
Cell. 2016 Jan 28;164(3):365-77
pubmed: 26806130
Cancer Immunol Res. 2019 Mar;7(3):388-400
pubmed: 30665890
Semin Immunol. 2014 Apr;26(2):138-44
pubmed: 24629893
Theranostics. 2018 Jun 14;8(14):3856-3869
pubmed: 30083264
Leukemia. 2007 Feb;21(2):356-9; author reply 359
pubmed: 17251901
Cell Res. 2020 Jul;30(7):610-622
pubmed: 32367039
Nature. 2013 Oct 10;502(7470):245-8
pubmed: 24037376
J Exp Med. 2003 Aug 18;198(4):557-67
pubmed: 12913096
Nat Immunol. 2019 Sep;20(9):1150-1160
pubmed: 31358996
Front Med (Lausanne). 2015 Dec 11;2:89
pubmed: 26697430
Lancet. 2000 Nov 25;356(9244):1795-9
pubmed: 11117911
Cold Spring Harb Perspect Biol. 2009 Jul;1(1):a000026
pubmed: 20066072
Immunity. 2015 Jul 21;43(1):146-60
pubmed: 26187413
PLoS One. 2011;6(6):e20740
pubmed: 21698239
Immunol Lett. 2011 Aug 30;138(2):93-6
pubmed: 21324341
Leukemia. 2010 Sep;24(9):1607-16
pubmed: 20613786
Nat Med. 2000 Apr;6(4):443-6
pubmed: 10742152
J Cell Physiol. 2020 Dec;235(12):9291-9303
pubmed: 32484595
Cancer Res. 2011 Aug 15;71(16):5412-22
pubmed: 21708957
Nat Protoc. 2014 Jan;9(1):171-81
pubmed: 24385147
Oncoimmunology. 2020 Sep 2;9(1):1777651
pubmed: 33457093
Cancer Immunol Res. 2021 May;9(5):554-567
pubmed: 33653716
Nat Immunol. 2013 Mar;14(3):221-9
pubmed: 23334791
Cancer Immunol Res. 2014 Dec;2(12):1125-31
pubmed: 25480554
Nature. 2006 Jul 27;442(7101):461-5
pubmed: 16688182
J Mol Med (Berl). 2012 Jan;90(1):55-66
pubmed: 21870102
Cancer Immunol Immunother. 2016 Apr;65(4):417-26
pubmed: 26288343
Haematologica. 2018 Aug;103(8):1390-1402
pubmed: 29700172
Front Immunol. 2018 Jan 05;8:1909
pubmed: 29354125
Front Immunol. 2020 Jul 02;11:1242
pubmed: 32714321
Nuklearmedizin. 2004 Oct;43(5):171-6
pubmed: 15480506
Cell. 2015 May 21;161(5):1202-1214
pubmed: 26000488
Nat Immunol. 2011 Jan;12(1):21-7
pubmed: 21113163
Cell. 2017 Sep 21;171(1):201-216.e18
pubmed: 28844693
J Biol Response Mod. 1990 Dec;9(6):546-55
pubmed: 2074441
Oncotarget. 2017 Jul 12;8(51):89256-89268
pubmed: 29179517
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Nat Immunol. 2010 Nov;11(11):1030-8
pubmed: 20935648
Immunology. 2018 Mar;153(3):297-303
pubmed: 29140572
Cancer Biol Med. 2020 Aug 15;17(3):726-739
pubmed: 32944402
F1000Res. 2016 Sep 08;5:
pubmed: 27635238
Bioinformatics. 2020 Apr 1;36(7):2311-2313
pubmed: 31764967
Sci Transl Med. 2015 Apr 15;7(283):283ra55
pubmed: 25877893
Front Immunol. 2018 Nov 12;9:2582
pubmed: 30483257
Stem Cells Transl Med. 2013 Apr;2(4):274-83
pubmed: 23515118
Front Immunol. 2016 May 18;7:188
pubmed: 27242795
Cancer Lett. 2021 Apr 1;502:34-43
pubmed: 33429004
Nat Immunol. 2016 Apr;17(4):451-60
pubmed: 26878113
J Clin Invest. 2017 Aug 1;127(8):2916-2929
pubmed: 28650339
Br J Pharmacol. 2020 Jul;177(13):2889-2903
pubmed: 32335915
Front Immunol. 2019 Sep 06;10:2121
pubmed: 31555301
Cells. 2021 Jul 31;10(8):
pubmed: 34440725
Cell. 2017 Mar 9;168(6):1086-1100.e10
pubmed: 28283063
Crit Rev Oncol Hematol. 2021 Apr;160:103261
pubmed: 33607229
J Immunol Res. 2014;2014:923135
pubmed: 24741632
J Exp Med. 2013 Mar 11;210(3):535-49
pubmed: 23420878
J Immunother. 2015 Jan;38(1):24-36
pubmed: 25415285
Nat Immunol. 2021 Jul;22(7):851-864
pubmed: 34099918
J Hepatol. 2020 Nov;73(5):1118-1130
pubmed: 32505533
Elife. 2019 Aug 08;8:
pubmed: 31393266
Cancer Immunol Res. 2019 Jul;7(7):1162-1174
pubmed: 31088844
Int J Mol Sci. 2018 Jan 25;19(2):
pubmed: 29370095
J Immunol. 2017 Oct 1;199(7):2536-2546
pubmed: 28814601
Nat Med. 2020 Jun;26(6):842-844
pubmed: 32398875
Cancer Immunol Res. 2020 Jun;8(6):724-731
pubmed: 32229590
Front Immunol. 2012 Jan 03;2:88
pubmed: 22566877
Elife. 2016 Jan 18;5:e10066
pubmed: 26780670
Nat Commun. 2017 Dec 11;8(1):2032
pubmed: 29230012
Nature. 2020 Mar;579(7797):130-135
pubmed: 32076273
Eur J Immunol. 2019 Jun;49(6):884-893
pubmed: 30892687
Eur J Immunol. 2001 Mar;31(3):792-801
pubmed: 11241284
Cell Discov. 2020 Apr 28;6:22
pubmed: 32351704
Nature. 2012 Nov 8;491(7423):254-8
pubmed: 23034650
Oncogene. 2003 Jan 30;22(4):517-27
pubmed: 12555065
Nat Biotechnol. 2019 May;37(5):547-554
pubmed: 30936559
Cancer Discov. 2020 Feb;10(2):185-197
pubmed: 31974169
J Invest Dermatol. 2014 Apr;134(4):984-991
pubmed: 24352038
Nat Rev Immunol. 2021 Jun 11;:
pubmed: 34117484
Haematologica. 2015 Apr;100(4):489-98
pubmed: 25596273
Haematologica. 2015 Jul;100(7):e257-60
pubmed: 25710455
J Immunol. 2019 Dec 15;203(12):3209-3215
pubmed: 31676672
Genome Biol. 2018 Feb 6;19(1):15
pubmed: 29409532
Nat Rev Immunol. 2012 Mar 22;12(4):239-52
pubmed: 22437937
Leukemia. 2018 Sep;32(9):1994-2007
pubmed: 29588546
Front Immunol. 2020 Feb 04;10:3111
pubmed: 32117199
BMC Cancer. 2013 Feb 05;13:59
pubmed: 23379788
Immunity. 2018 Nov 20;49(5):971-986.e5
pubmed: 30413361
Nat Commun. 2021 Jun 9;12(1):3501
pubmed: 34108465
Int Immunol. 2016 Jan;28(1):43-52
pubmed: 26451009
Blood. 2007 Jan 1;109(1):323-30
pubmed: 16940427
Blood. 2017 Jul 20;130(3):297-309
pubmed: 28495792
J Hematother Stem Cell Res. 2001 Aug;10(4):535-44
pubmed: 11522236
Nat Methods. 2014 Jan;11(1):1
pubmed: 24524124
Front Immunol. 2019 Apr 03;10:656
pubmed: 31024531
J Immunol. 2012 Aug 1;189(3):1360-71
pubmed: 22730533
Cancer Res. 2017 Mar 1;77(5):1083-1096
pubmed: 28082403
J Immunol. 2012 Jan 15;188(2):703-13
pubmed: 22174445
Nature. 2019 Nov;575(7783):512-518
pubmed: 31597160
NAR Genom Bioinform. 2020 Sep;2(3):lqaa052
pubmed: 32766548
Front Immunol. 2017 Mar 16;8:293
pubmed: 28360915
Cancer Immunol Res. 2020 Apr;8(4):556-564
pubmed: 32019778
PLoS One. 2019 Apr 25;14(4):e0215481
pubmed: 31022195
Innate Immun. 2013 Feb;19(1):76-85
pubmed: 22781631
Cell. 2021 Jun 24;184(13):3573-3587.e29
pubmed: 34062119
Mol Cell. 2019 Jan 3;73(1):130-142.e5
pubmed: 30472192
Nat Immunol. 2018 Oct;19(10):1093-1099
pubmed: 30201992
Nat Immunol. 2003 Jun;4(6):565-72
pubmed: 12740576
Trends Immunol. 2013 Dec;34(12):573-82
pubmed: 24055329
Science. 2014 Mar 28;343(6178):1249288
pubmed: 24625929
Nat Rev Cancer. 2020 Oct;20(10):594-607
pubmed: 32678342
Mol Ther Oncolytics. 2021 May 08;21:183-206
pubmed: 34027052
Nat Immunol. 2018 Aug;19(8):800-808
pubmed: 30026479
Sci Rep. 2018 Feb 13;8(1):2924
pubmed: 29440650
J Exp Med. 2020 Mar 2;217(3):
pubmed: 31816636
Blood. 2002 May 15;99(10):3661-7
pubmed: 11986221
Cell Biol Int. 2008 Feb;32(2):188-97
pubmed: 17920947
Haematologica. 2016 Nov;101(11):e461-e464
pubmed: 27662009
Nat Immunol. 2009 Jan;10(1):75-82
pubmed: 19029904
Clin Cancer Res. 2019 Aug 1;25(15):4634-4643
pubmed: 31053601
Oncoimmunology. 2016 Apr 25;6(1):e1137418
pubmed: 28197361
Nat Commun. 2017 Sep 19;8(1):593
pubmed: 28928446
Science. 2002 Mar 15;295(5562):2097-100
pubmed: 11896281
J Immunol. 2005 Oct 15;175(8):5095-103
pubmed: 16210613
Front Immunol. 2020 Feb 13;11:167
pubmed: 32117298
FEBS Lett. 2014 Nov 3;588(21):3998-4007
pubmed: 25261255
Leukemia. 2005 May;19(5):835-40
pubmed: 15744340
Biochim Biophys Acta. 2011 Dec;1816(2):119-31
pubmed: 21658434
Blood Cancer J. 2015 Apr 17;5:e306
pubmed: 25885426
J Exp Med. 1982 Jun 1;155(6):1823-41
pubmed: 6176669
Immunity. 2020 Oct 13;53(4):775-792.e9
pubmed: 33002412
Blood. 2018 Apr 19;131(16):1809-1819
pubmed: 29449276
Biol Blood Marrow Transplant. 2019 Jul;25(7):1281-1292
pubmed: 30878607
J Hematol Oncol. 2021 Jan 6;14(1):7
pubmed: 33407739
Semin Immunol. 2019 Feb;41:101274
pubmed: 31072659
Nat Methods. 2020 Feb;17(2):137-145
pubmed: 31792435
Front Immunol. 2015 Nov 06;6:564
pubmed: 26594214
Scand J Immunol. 2007 Feb;65(2):126-38
pubmed: 17257217
Semin Immunol. 2019 Feb;41:101284
pubmed: 31383506
Immunol Cell Biol. 2014 Mar;92(3):221-9
pubmed: 24366519
Nat Immunol. 2019 Aug;20(8):980-991
pubmed: 31209406
Nat Biotechnol. 2012 Aug;30(8):777-82
pubmed: 22820318
Immunity. 2013 Feb 21;38(2):275-84
pubmed: 23333074
Mol Carcinog. 2021 May;60(5):297-312
pubmed: 33721368
Cell Physiol Biochem. 2017;44(3):1038-1050
pubmed: 29179214
PLoS One. 2007 Feb 21;2(2):e232
pubmed: 17311098
Immunity. 2020 Oct 13;53(4):745-758.e4
pubmed: 33010223
Blood. 2013 May 2;121(18):3599-608
pubmed: 23487023
Annu Rev Immunol. 2011;29:235-71
pubmed: 21219185
Immunity. 2020 Jun 16;52(6):1075-1087.e8
pubmed: 32445619
Blood. 2007 Jun 1;109(11):4816-24
pubmed: 17341666
Nature. 2016 Nov 3;539(7627):102-106
pubmed: 27749818
Blood. 2003 Apr 15;101(8):3052-7
pubmed: 12480696
Oncoimmunology. 2018 Oct 19;8(2):e1527498
pubmed: 30713781
Trends Immunol. 2016 Jan;37(1):68-79
pubmed: 26708278
Trends Immunol. 2001 Nov;22(11):633-40
pubmed: 11698225
PLoS One. 2013 Nov 04;8(11):e78049
pubmed: 24223759
Immunity. 2017 Nov 21;47(5):820-833
pubmed: 29166586
J Exp Med. 1991 Jul 1;174(1):139-49
pubmed: 1711560
Nat Rev Cancer. 2020 Aug;20(8):437-454
pubmed: 32581320
Nat Rev Immunol. 2018 Nov;18(11):671-688
pubmed: 30209347
Immunity. 2019 Oct 15;51(4):682-695.e6
pubmed: 31353223
Annu Rev Immunol. 2001;19:683-765
pubmed: 11244051
Cancer Immunol Res. 2016 Mar;4(3):215-24
pubmed: 26787822
Biol Blood Marrow Transplant. 1997 Oct;3(4):217-23
pubmed: 9360784
Nat Med. 2020 Jul;26(7):1070-1076
pubmed: 32514174
Blood Adv. 2017 Nov 20;1(25):2343-2347
pubmed: 29296884
Cell Mol Immunol. 2017 Oct;14(10):819-829
pubmed: 27321064
Immunol Rev. 2021 Mar;300(1):152-166
pubmed: 33559175
Am J Cancer Res. 2019 Oct 01;9(10):2064-2078
pubmed: 31720075
Bioinformatics. 2017 Apr 15;33(8):1179-1186
pubmed: 28088763
Arch Surg. 1987 Nov;122(11):1264-8
pubmed: 3675190
Evolution. 2021 Oct;75(10):2600-2612
pubmed: 34347301
J Exp Med. 2013 May 6;210(5):917-31
pubmed: 23589566
Nat Rev Cancer. 2006 Jan;6(1):24-37
pubmed: 16397525
Immunity. 2021 Jun 8;54(6):1320-1337.e4
pubmed: 33945787
Clin Immunol. 2013 Apr;147(1):38-39
pubmed: 23501837
Front Oncol. 2021 Feb 03;10:593085
pubmed: 33614479
Cell Mol Immunol. 2019 May;16(5):430-441
pubmed: 30778167
Oncoimmunology. 2016 Mar 10;5(12):e1154251
pubmed: 28123867
Stem Cells Dev. 2007 Dec;16(6):1043-51
pubmed: 17999637
Cell Rep Med. 2021 Jul 27;2(8):100353
pubmed: 34467243
Immunol Rev. 2001 Jun;181:170-84
pubmed: 11513138
Blood. 2018 Jun 7;131(23):2515-2527
pubmed: 29463563
Immunity. 1996 Jun;4(6):573-81
pubmed: 8673704
Front Immunol. 2021 Jan 25;11:586126
pubmed: 33569050
Front Immunol. 2016 Nov 15;7:504
pubmed: 27895646
Oncoimmunology. 2015 Feb 03;4(1):e984539
pubmed: 25949866
BMC Cancer. 2009 Jun 16;9:186
pubmed: 19531227
Nat Commun. 2015 Sep 23;6:8280
pubmed: 26395069
Blood. 2011 Jan 13;117(2):510-8
pubmed: 21048157
Nat Commun. 2018 Oct 22;9(1):4383
pubmed: 30348985
JCI Insight. 2019 Dec 5;4(23):
pubmed: 31801909
Cancer. 2008 Feb 15;112(4):863-75
pubmed: 18203207
Nat Immunol. 2020 Sep;21(9):998-1009
pubmed: 32747815
Nature. 2018 Dec;564(7735):268-272
pubmed: 30479382
Blood. 2001 May 15;97(10):3146-51
pubmed: 11342442
Clin Cancer Res. 2019 Dec 15;25(24):7506-7516
pubmed: 31548346
PLoS One. 2012;7(9):e46264
pubmed: 23050001
J Exp Med. 2013 Jun 3;210(6):1179-87
pubmed: 23650439
Oncoimmunology. 2017 Jul 5;6(10):e1345402
pubmed: 29123956
Cell Rep. 2020 Feb 25;30(8):2743-2757.e5
pubmed: 32101749
Blood. 2005 Apr 15;105(8):3051-7
pubmed: 15632206
Immunol Res. 2015 Jul;62(3):341-56
pubmed: 26013798
Blood. 2010 Sep 30;116(13):2286-94
pubmed: 20460501
Cell. 2021 Sep 16;184(19):5015-5030.e16
pubmed: 34407392
Front Immunol. 2017 Jun 12;8:683
pubmed: 28659921
J Clin Invest. 2011 Sep;121(9):3609-22
pubmed: 21841316
Nature. 2021 Apr;592(7852):128-132
pubmed: 33536623
Cancers (Basel). 2021 Feb 01;13(3):
pubmed: 33535624
Cell Mol Immunol. 2021 May;18(5):1290-1304
pubmed: 33239726
Genome Biol. 2020 Feb 7;21(1):31
pubmed: 32033589
J Immunol. 1999 Apr 15;162(8):4511-20
pubmed: 10201989
Annu Rev Immunol. 2001;19:197-223
pubmed: 11244035
Immunity. 2017 Jan 17;46(1):148-161
pubmed: 27986455
Blood. 2013 May 2;121(18):3658-65
pubmed: 23509156
Nature. 2019 Aug;572(7768):199-204
pubmed: 31292543
Nat Rev Immunol. 2017 Nov;17(11):665-678
pubmed: 28804130
Signal Transduct Target Ther. 2021 Mar 6;6(1):110
pubmed: 33677468
PLoS Biol. 2019 Nov 21;17(11):e3000528
pubmed: 31751331
Nat Immunol. 2017 Sep;18(9):1004-1015
pubmed: 28759001
Nature. 2015 Jan 15;517(7534):293-301
pubmed: 25592534
Cell. 2010 Mar 19;140(6):883-99
pubmed: 20303878
Cell Res. 2021 May;31(5):554-568
pubmed: 33420427
Science. 2014 Jan 10;343(6167):193-6
pubmed: 24408435
Cell Rep. 2016 Oct 4;17(2):436-447
pubmed: 27705792
J Biol Chem. 2006 Dec 8;281(49):37728-37
pubmed: 17035230
Nat Immunol. 2019 Aug;20(8):992-1003
pubmed: 31263279
Front Immunol. 2016 Jun 24;7:251
pubmed: 27446081
Cancers (Basel). 2021 Mar 23;13(6):
pubmed: 33807011
Mol Immunol. 2017 Dec;92:45-53
pubmed: 29040918
J Cell Biol. 2018 Sep 3;217(9):3267-3283
pubmed: 29967280
Clin Cancer Res. 2021 Dec 1;27(23):6298-6306
pubmed: 34253582
Annu Rev Immunol. 1998;16:359-93
pubmed: 9597134
Cell. 2015 May 21;161(5):1187-1201
pubmed: 26000487
J Immunol. 2020 Jun 15;204(12):3171-3181
pubmed: 32332109
Nat Rev Immunol. 2007 Apr;7(4):255-66
pubmed: 17380156
EBioMedicine. 2019 Mar;41:333-344
pubmed: 30827928
Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):
pubmed: 34244432
Immunol Rev. 2017 Mar;276(1):112-120
pubmed: 28258695
J Clin Oncol. 2017 Jun 1;35(16):1760-1763
pubmed: 28368671
Oncoimmunology. 2016 May 13;6(1):e1163456
pubmed: 28197362
Front Immunol. 2019 Sep 24;10:2278
pubmed: 31616440
BMC Cancer. 2018 Mar 27;18(1):341
pubmed: 29587679
Immunol Cell Biol. 2011 Feb;89(2):216-24
pubmed: 20567250