Transcriptomics and Metabolomics Integration Reveals Redox-Dependent Metabolic Rewiring in Breast Cancer Cells.

CtBP2 cancer metabolic rewiring epigenetics metabolomics integration transcriptomics

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
09 Oct 2021
Historique:
received: 03 09 2021
revised: 04 10 2021
accepted: 06 10 2021
entrez: 23 10 2021
pubmed: 24 10 2021
medline: 24 10 2021
Statut: epublish

Résumé

Rewiring glucose metabolism toward aerobic glycolysis provides cancer cells with a rapid generation of pyruvate, ATP, and NADH, while pyruvate oxidation to lactate guarantees refueling of oxidized NAD

Identifiants

pubmed: 34680207
pii: cancers13205058
doi: 10.3390/cancers13205058
pmc: PMC8534001
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : FOE2018

Références

Int J Cell Biol. 2013;2013:647975
pubmed: 23762064
Oncotarget. 2016 Aug 9;7(32):52017-52031
pubmed: 27409831
Front Oncol. 2020 Mar 06;10:281
pubmed: 32211323
Circ Res. 2015 Feb 13;116(4):715-36
pubmed: 25677519
Bioorg Med Chem. 2016 Jun 15;24(12):2707-15
pubmed: 27156192
FEBS Lett. 2014 May 2;588(9):1743-8
pubmed: 24657618
Protein Cell. 2021 May 29;:
pubmed: 34050894
Cell Cycle. 2010 Sep 15;9(18):3740-50
pubmed: 20930544
J Cell Sci. 2017 Feb 1;130(3):626-636
pubmed: 28049720
FEBS Lett. 2003 Apr 10;540(1-3):255-8
pubmed: 12681518
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9202-7
pubmed: 12872005
Annu Rev Pharmacol Toxicol. 2010;50:157-86
pubmed: 20055701
Nat Rev Cancer. 2014 Jan;14(1):49-60
pubmed: 24505619
Cancer Genomics Proteomics. 2019 Jul-Aug;16(4):257-266
pubmed: 31243106
Cancer Res. 2009 Feb 1;69(3):731-4
pubmed: 19155295
Nature. 2003 Apr 17;422(6933):735-8
pubmed: 12700765
Biomark Insights. 2018 Feb 06;13:1177271918755391
pubmed: 29449774
Nucleic Acids Res. 2016 Jan 4;44(D1):D380-4
pubmed: 26590256
Int J Dev Biol. 2008;52(7):811-21
pubmed: 18956313
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Int J Mol Sci. 2020 May 12;21(10):
pubmed: 32408513
Mol Syst Biol. 2011 Aug 16;7:523
pubmed: 21847114
Oncotarget. 2015 Aug 21;6(24):20604-20
pubmed: 26098771
Nat Commun. 2013;4:1449
pubmed: 23385593
Cell Metab. 2017 Mar 7;25(3):572-579
pubmed: 28273479
EMBO J. 2017 Dec 1;36(23):3409-3420
pubmed: 29127156
Nat Commun. 2020 Jan 3;11(1):102
pubmed: 31900386
Oncotarget. 2016 Jan 12;7(2):1741-53
pubmed: 26646320
PLoS One. 2013 Oct 17;8(10):e77586
pubmed: 24147030
J Cell Biol. 2007 Jul 2;178(1):93-105
pubmed: 17606868
J Radiat Res. 2019 Jul 1;60(4):451-465
pubmed: 31135901
Science. 2020 Apr 10;368(6487):
pubmed: 32273439
Br J Cancer. 2014 Apr 15;110(8):2144-58
pubmed: 24667650
PLoS Comput Biol. 2017 Sep 28;13(9):e1005758
pubmed: 28957320
Curr Opin Oncol. 2019 Mar;31(2):92-99
pubmed: 30562315
ACS Chem Biol. 2015 Apr 17;10(4):1118-27
pubmed: 25636004
Science. 2009 May 22;324(5930):1029-33
pubmed: 19460998
Biol Cell. 2010 Jan;103(1):1-19
pubmed: 20964627
Biochem J. 2007 Apr 1;403(1):119-27
pubmed: 17125467
Genome Res. 2009 Sep;19(9):1639-45
pubmed: 19541911
Cell Metab. 2015 Dec 1;22(6):1068-77
pubmed: 26603296
Cancer Cell Int. 2014 Nov 30;14(1):130
pubmed: 25550687
Curr Opin Chem Biol. 2021 Aug;63:11-18
pubmed: 33667809
Cell Death Dis. 2014 Dec 04;5:e1561
pubmed: 25476909
Cancer Biol Ther. 2017 Jun 3;18(6):379-391
pubmed: 28532298
Curr Opin Biotechnol. 2020 Jun;63:190-199
pubmed: 32278263
J Mol Med (Berl). 2021 Oct;99(10):1335-1347
pubmed: 34196767
Commun Biol. 2021 Mar 19;4(1):371
pubmed: 33742081
Br J Cancer. 2020 Jan;122(2):133-135
pubmed: 31819199
Biochim Biophys Acta. 2011 Jun;1807(6):552-61
pubmed: 20955683
Nat Genet. 2013 Oct;45(10):1113-20
pubmed: 24071849
J Clin Invest. 2014 Jan;124(1):398-412
pubmed: 24316975
Front Chem. 2018 Jun 22;6:243
pubmed: 29988369
Oncogenesis. 2018 Mar 13;7(3):26
pubmed: 29540733
Semin Cancer Biol. 2005 Aug;15(4):254-66
pubmed: 15916903
Med Hypotheses. 1995 Nov;45(5):486-90
pubmed: 8748093
Int J Mol Sci. 2017 Dec 19;18(12):
pubmed: 29257069
Cancer Metab. 2020 Sep 29;8:22
pubmed: 33005401
Int J Biochem Cell Biol. 2007;39(9):1593-607
pubmed: 17336131
Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9643-8
pubmed: 16769891

Auteurs

Marcella Bonanomi (M)

ISBE. IT/Centre of Systems Biology, 20126 Milan, Italy.
Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.

Noemi Salmistraro (N)

ISBE. IT/Centre of Systems Biology, 20126 Milan, Italy.
Institute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), 20054 Segrate, MI and 90015 Cefalù, PA, Italy.

Giulia Fiscon (G)

Institute for Systems Analysis and Computer Science "Antonio Ruberti" (IASI), National Research Council (CNR), 00185 Rome, Italy.
Fondazione per la Medicina Personalizzata, 16122 Genova, Italy.

Federica Conte (F)

Institute for Systems Analysis and Computer Science "Antonio Ruberti" (IASI), National Research Council (CNR), 00185 Rome, Italy.

Paola Paci (P)

Institute for Systems Analysis and Computer Science "Antonio Ruberti" (IASI), National Research Council (CNR), 00185 Rome, Italy.
Department of Computer, Control and Management Engineering, Sapienza University of Rome, 00185 Rome, Italy.

Valentina Bravatà (V)

Institute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), 20054 Segrate, MI and 90015 Cefalù, PA, Italy.

Giusi Irma Forte (GI)

Institute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), 20054 Segrate, MI and 90015 Cefalù, PA, Italy.

Tatiana Volpari (T)

ISBE. IT/Centre of Systems Biology, 20126 Milan, Italy.
The New York Stem Cell Foundation Research Institute, New York, NY 10019, USA.

Manuela Scorza (M)

ISBE. IT/Centre of Systems Biology, 20126 Milan, Italy.

Fabrizia Mastroianni (F)

ISBE. IT/Centre of Systems Biology, 20126 Milan, Italy.

Stefano D'Errico (S)

Department of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.

Elenio Avolio (E)

Institute of Atmospheric Sciences and Climate (ISAC), National Research Council (CNR), 88046 Lamezia Terme, Italy.

Gennaro Piccialli (G)

Department of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.

Anna Maria Colangelo (AM)

ISBE. IT/Centre of Systems Biology, 20126 Milan, Italy.
Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.

Marco Vanoni (M)

ISBE. IT/Centre of Systems Biology, 20126 Milan, Italy.
Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.

Daniela Gaglio (D)

ISBE. IT/Centre of Systems Biology, 20126 Milan, Italy.
Institute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), 20054 Segrate, MI and 90015 Cefalù, PA, Italy.

Lilia Alberghina (L)

ISBE. IT/Centre of Systems Biology, 20126 Milan, Italy.
Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.

Classifications MeSH