Prognostic Gene Signature for Squamous Cell Carcinoma with a Higher Risk for Treatment Failure and Accelerated MEK-ERK Pathway Activity.
HNSCC
MEK inhibitors
MEK-ERK signaling
genetic and epigenetic alterations
multi-omics analysis
prognostic classifier
squamous cell carcinoma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
15 Oct 2021
15 Oct 2021
Historique:
received:
30
08
2021
revised:
07
10
2021
accepted:
09
10
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
24
10
2021
Statut:
epublish
Résumé
Squamous cell carcinoma (SCC) is the most prevalent histological type of human cancer, including head and neck squamous cell carcinoma (HNSCC). However, reliable prognostic gene signatures for SCC and underlying genetic and/or epigenetic principles are still unclear. We identified 37 prognostic candidate genes by best cutoff computation based on survival in a pan-SCC cohort (
Identifiants
pubmed: 34680330
pii: cancers13205182
doi: 10.3390/cancers13205182
pmc: PMC8534038
pii:
doi:
Types de publication
Journal Article
Langues
eng
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