Targeting Drug Chemo-Resistance in Cancer Using Natural Products.
anticancer natural products
drug detoxification
drug efflux
plants derived natural products
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
29 Sep 2021
29 Sep 2021
Historique:
received:
21
08
2021
revised:
22
09
2021
accepted:
23
09
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
24
10
2021
Statut:
epublish
Résumé
Cancer is one of the leading causes of death globally. The development of drug resistance is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms to reduce the therapeutic effects of anticancer drugs, thereby causing chemotherapy failure. Natural products are accessible, inexpensive, and less toxic sources of chemotherapeutic agents. Additionally, they have multiple mechanisms of action to inhibit various targets involved in the development of drug resistance. In this review, we have summarized the basic research and clinical applications of natural products as possible inhibitors for drug resistance in cancer. The molecular targets and the mechanisms of action of each natural product are also explained. Diverse drug resistance biomarkers were sensitive to natural products. P-glycoprotein and breast cancer resistance protein can be targeted by a large number of natural products. On the other hand, protein kinase C and topoisomerases were less sensitive to most of the studied natural products. The studies discussed in this review will provide a solid ground for scientists to explore the possible use of natural products in combination anticancer therapies to overcome drug resistance by targeting multiple drug resistance mechanisms.
Identifiants
pubmed: 34680470
pii: biomedicines9101353
doi: 10.3390/biomedicines9101353
pmc: PMC8533186
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Front Pharmacol. 2020 Jun 19;11:832
pubmed: 32636741
Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24583-24592
pubmed: 31732667
Semin Cancer Biol. 2017 Oct;46:65-83
pubmed: 28254675
J Cell Sci. 2006 Sep 15;119(Pt 18):3888-900
pubmed: 16940348
Nat Rev Mol Cell Biol. 2017 Feb;18(2):127-136
pubmed: 27999438
Gynecol Oncol. 2007 Dec;107(3):450-7
pubmed: 17825886
Free Radic Res. 2011 Nov;45(11-12):1307-24
pubmed: 21875385
Sci Rep. 2014 Sep 17;4:6394
pubmed: 25227736
Nature. 2014 Oct 30;514(7524):628-32
pubmed: 25119024
Semin Reprod Med. 2009 Sep;27(5):351-7
pubmed: 19711245
Mol Biol Rep. 2020 Jul;47(7):5495-5501
pubmed: 32494978
FEBS J. 2009 Mar;276(5):1291-306
pubmed: 19187231
Cancer. 2003 Mar 15;97(6):1442-6
pubmed: 12627508
J Nat Prod. 1991 Nov-Dec;54(6):1656-60
pubmed: 1812215
Clin Cancer Res. 2002 Mar;8(3):811-6
pubmed: 11895913
Cancer Lett. 2015 Feb 1;357(1):75-82
pubmed: 25448403
Adv Pharm Bull. 2020 Jul;10(3):472-476
pubmed: 32665908
Cancer Invest. 2000;18(8):731-9
pubmed: 11107443
Chem Rev. 2015 May 13;115(9):2975-3011
pubmed: 25906056
Nutr Cancer. 2009;61(5):587-97
pubmed: 19838932
Front Pharmacol. 2012 Feb 28;3:25
pubmed: 22403544
Eur J Cancer. 2005 Sep;41(13):1955-68
pubmed: 16081279
Oncogene. 2012 Oct 18;31(42):4567-76
pubmed: 22249249
Anticancer Res. 2005 May-Jun;25(3B):2069-74
pubmed: 16158947
PLoS One. 2014 Nov 10;9(11):e112470
pubmed: 25383959
Ann Intern Med. 2002 Jan 1;136(1):42-53
pubmed: 11777363
Carcinogenesis. 2015 Jun;36 Suppl 1:S111-27
pubmed: 26002081
Molecules. 2018 Nov 22;23(12):
pubmed: 30469543
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2015 Dec;35(12):1490-4
pubmed: 26882613
Gynecol Oncol. 1998 Aug;70(2):176-82
pubmed: 9740686
Mol Biol Cell. 2012 May;23(10):1860-73
pubmed: 22456507
Aging (Albany NY). 2020 Dec 3;13(1):364-375
pubmed: 33290263
Oncoscience. 2014 Oct 22;1(10):649-64
pubmed: 25593994
Oncol Lett. 2017 Jan;13(1):389-395
pubmed: 28123572
Onco Targets Ther. 2015 Jul 29;8:1941-8
pubmed: 26251616
Oncoimmunology. 2012 Sep 1;1(6):917-923
pubmed: 23162759
Oncotarget. 2015 Jul 10;6(19):17328-41
pubmed: 26093146
Asian Pac J Cancer Prev. 2014;15(3):1403-10
pubmed: 24606473
Nature. 2019 Dec;576(7787):477-481
pubmed: 31827278
Asian Pac J Cancer Prev. 2014;15(12):4897-902
pubmed: 24998560
Front Pharmacol. 2021 May 28;12:678126
pubmed: 34135758
Sci Rep. 2017 Aug 11;7(1):7972
pubmed: 28801675
Eur J Med Chem. 2021 Sep 1;226:113795
pubmed: 34597896
Pharmacol Res. 2015 May-Jun;95-96:2-11
pubmed: 25749008
Cell. 2004 Aug 6;118(3):285-96
pubmed: 15294155
Oncol Res. 1997;9(6-7):295-302
pubmed: 9406235
Toxicol Appl Pharmacol. 2013 Jan 1;266(1):9-18
pubmed: 23147571
PLoS One. 2014 Jan 23;9(1):e87064
pubmed: 24466327
Cancer Treat Rev. 2008 Oct;34(6):505-20
pubmed: 18413281
EBioMedicine. 2016 Dec;14:15-23
pubmed: 28029600
BMC Cancer. 2019 Jan 16;19(1):77
pubmed: 30651087
Stem Cells. 1996 Jan;14(1):47-55
pubmed: 8820951
Cancer Lett. 2014 Feb 28;343(2):179-89
pubmed: 24125861
Biochem Pharmacol. 2014 Nov 1;92(1):157-63
pubmed: 24976506
Semin Cell Dev Biol. 2015 Mar;39:43-55
pubmed: 25724561
Am J Cancer Res. 2015 Jul 15;5(8):2361-75
pubmed: 26396912
Oral Dis. 2015 Apr;21(3):283-91
pubmed: 24797102
Ann Oncol. 2017 Jul 1;28(7):1448-1456
pubmed: 28407030
Mol Cell Biochem. 2007 Feb;296(1-2):85-95
pubmed: 16960658
Nat Prod Bioprospect. 2018 Aug;8(4):303-319
pubmed: 29633188
Biomed Pharmacother. 2018 Jul;103:29-37
pubmed: 29635125
Pharmacol Res Perspect. 2020 Jan 17;8(1):e00544
pubmed: 31988753
Molecules. 2020 Jan 07;25(2):
pubmed: 31936160
Oncol Rep. 2014 Jul;32(1):235-42
pubmed: 24859482
J Clin Invest. 2010 Apr;120(4):1310-23
pubmed: 20200450
Int J Biol Sci. 2018 Oct 20;14(13):1883-1891
pubmed: 30443191
Autophagy. 2014 Mar;10(3):529-31
pubmed: 24413089
Cancer Cell. 2016 Jul 11;30(1):147-160
pubmed: 27411589
Cancer Discov. 2014 Aug;4(8):914-27
pubmed: 24875857
Carcinogenesis. 2007 May;28(5):1021-31
pubmed: 17148506
Phytother Res. 2014 Dec;28(12):1761-9
pubmed: 25044209
Drug Metab Dispos. 2008 Jul;36(7):1206-11
pubmed: 18436619
Oncol Rep. 2017 Jan;37(1):3-9
pubmed: 27841002
Nat Rev Drug Discov. 2016 May;15(5):348-66
pubmed: 26775689
Semin Cell Dev Biol. 2014 Nov;35:51-6
pubmed: 25065969
Cell Death Differ. 2020 Mar;27(3):843-857
pubmed: 31836831
Curr Opin Drug Discov Devel. 2009 Mar;12(2):189-96
pubmed: 19333864
Biochem Pharmacol. 2002 Feb 15;63(4):607-13
pubmed: 11992628
J Exp Clin Cancer Res. 2018 Jul 3;37(1):132
pubmed: 29970196
Bioorg Med Chem. 1996 Jun;4(6):781-91
pubmed: 8818227
Acta Pharmacol Sin. 2012 Aug;33(8):1055-61
pubmed: 22842735
Annu Rev Pharmacol Toxicol. 2005;45:51-88
pubmed: 15822171
Biomol Ther (Seoul). 2014 Sep;22(5):426-30
pubmed: 25414773
Prostate. 2014 Sep;74(12):1209-21
pubmed: 25043291
Biochem Biophys Res Commun. 2010 Apr 23;395(1):104-10
pubmed: 20350534
Trends Biochem Sci. 1991 May;16(5):167-9
pubmed: 1820763
Oncogene. 1999 Apr 1;18(13):2281-90
pubmed: 10327074
Nat Rev Mol Cell Biol. 2014 Feb;15(2):135-47
pubmed: 24452471
FEBS J. 2005 Sep;272(18):4725-40
pubmed: 16156793
Cancer Prev Res (Phila). 2011 Jul;4(7):973-83
pubmed: 21733821
Curr Drug Targets. 2011 Oct;12(11):1560-73
pubmed: 21561425
Cell Cycle. 2008 May 15;7(10):1353-9
pubmed: 18418074
Biochem Pharmacol. 2015 Mar 1;94(1):1-11
pubmed: 25562745
PLoS One. 2014 Jul 03;9(7):e101526
pubmed: 24992302
Proc Natl Acad Sci U S A. 1987 Jan;84(1):265-9
pubmed: 2432605
Cell Cycle. 2010 Aug 15;9(16):3256-76
pubmed: 20814239
Int J Biochem Mol Biol. 2012;3(1):1-27
pubmed: 22509477
JAMA Oncol. 2018 Oct 1;4(10):1375-1381
pubmed: 30027204
Biochim Biophys Acta. 2013 Jun;1830(6):3670-95
pubmed: 23428572
Phytother Res. 2020 Oct;34(10):2438-2458
pubmed: 32255545
Mol Pharmacol. 2004 May;65(5):1208-16
pubmed: 15102949
Acta Pharmacol Sin. 2015 Jun;36(6):676-9
pubmed: 25982630
Int J Oncol. 2015 Mar;46(3):963-72
pubmed: 25530098
J Natl Cancer Inst Monogr. 2001;(28):30-7
pubmed: 11158204
Lab Invest. 2011 Aug;91(8):1146-57
pubmed: 21647092
Food Funct. 2021 Aug 21;12(16):7126-7144
pubmed: 34180492
Cancer Invest. 2021 Sep;39(8):675-684
pubmed: 34241563
Bioconjug Chem. 2020 Mar 18;31(3):547-553
pubmed: 32017537
Int J Mol Sci. 2018 Nov 28;19(12):
pubmed: 30487385
Cancer Chemother Pharmacol. 2017 May;79(5):959-969
pubmed: 28378028
PLoS One. 2012;7(7):e41945
pubmed: 22860037
Int J Mol Sci. 2021 Apr 28;22(9):
pubmed: 33925129
Toxicology. 2010 Nov 28;278(1):88-100
pubmed: 19903510
Onco Targets Ther. 2016 Jun 02;9:3359-68
pubmed: 27330316
Science. 2011 Dec 16;334(6062):1573-7
pubmed: 22174255
Planta Med. 1998 May;64(4):353-6
pubmed: 9619120
Toxins (Basel). 2010 Jun;2(6):1207-24
pubmed: 22069634
PLoS One. 2014 Apr 07;9(4):e94079
pubmed: 24710512
J Nanobiotechnology. 2007 Apr 17;5:3
pubmed: 17439648
Cancer Treat Rev. 2013 Nov;39(7):773-83
pubmed: 23394826
Cancer Lett. 2004 Nov 25;215(2):159-66
pubmed: 15488634
Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20778-83
pubmed: 22143792
Biomed Res Int. 2015;2015:934207
pubmed: 25821829
Apoptosis. 2011 Oct;16(10):1042-53
pubmed: 21779837
Cancer. 2018 Aug;124(16):3307-3318
pubmed: 29671878
Cell Signal. 2011 Sep;23(9):1466-72
pubmed: 21554950
Drug Discov Ther. 2012 Oct;6(5):230-7
pubmed: 23229142
Biochem Biophys Res Commun. 2014 Jul 18;450(1):247-54
pubmed: 24887566
Front Pharmacol. 2021 May 21;12:658513
pubmed: 34093189
Mol Nutr Food Res. 2011 Nov;55(11):1646-54
pubmed: 21928294
Biomed Environ Sci. 2013 Nov;26(11):902-11
pubmed: 24331535
Nature. 2017 Jan 19;541(7637):417-420
pubmed: 28077876
Cancer Biol Ther. 2003 Sep-Oct;2(5):477-90
pubmed: 14614312
Cancer Res. 2004 Jan 15;64(2):696-703
pubmed: 14744787
Mar Drugs. 2015 Jul 31;13(8):4784-98
pubmed: 26264004
Mol Cancer Ther. 2003 Jan;2(1):65-72
pubmed: 12533674
J Agric Food Chem. 2015 Feb 11;63(5):1540-6
pubmed: 25611974
Curr Pharmacol Rep. 2015 Apr;1(2):129-139
pubmed: 26457241
J Agric Food Chem. 2012 Aug 29;60(34):8363-71
pubmed: 22860996
Radiother Oncol. 2015 Mar;114(3):351-6
pubmed: 25769379
Clinics (Sao Paulo). 2018 Sep 06;73(suppl 1):e478s
pubmed: 30208165
Front Oncol. 2020 Jun 24;10:992
pubmed: 32670880
J Agric Food Chem. 2009 Sep 23;57(18):8142-60
pubmed: 19719126
Phytother Res. 2012 Dec;26(12):1779-83
pubmed: 22388865
Cancer Cell Int. 2019 Jan 5;19:7
pubmed: 30627053
Metabolites. 2021 Mar 23;11(3):
pubmed: 33806779
Cell Death Dis. 2013 Aug 01;4:e750
pubmed: 23907464
J Womens Health Gend Based Med. 2002 Jan-Feb;11(1):79-87
pubmed: 11860728
Cell Mol Life Sci. 2016 Jun;73(11-12):2183-93
pubmed: 27048810
Autophagy. 2007 Sep-Oct;3(5):490-2
pubmed: 17617736
Invest New Drugs. 2012 Feb;30(1):212-22
pubmed: 20924640
Anticancer Agents Med Chem. 2012 Dec;12(10):1264-80
pubmed: 22583407
Curr Drug Targets. 2012 Dec;13(14):1831-41
pubmed: 23140293
Biochem Pharmacol. 2017 May 15;132:29-37
pubmed: 28242251
Cell. 2008 Jan 11;132(1):27-42
pubmed: 18191218
Chin Med. 2019 Nov 6;14:48
pubmed: 31719837
Cancers (Basel). 2020 Feb 29;12(3):
pubmed: 32121322
PLoS One. 2013 Jun 24;8(6):e67589
pubmed: 23826324
Cell Mol Life Sci. 2015 Feb;72(3):505-517
pubmed: 25323133
Medicines (Basel). 2018 Jun 20;5(2):
pubmed: 29925764
Annu Rev Cell Dev Biol. 2011;27:107-32
pubmed: 21801009
Biochim Biophys Acta. 1993 Mar 20;1172(3):283-91
pubmed: 8383537
Cancer Gene Ther. 2007 Nov;14(11):875-84
pubmed: 17704753
Cell Biochem Funct. 2021 Mar;39(2):277-286
pubmed: 32815556
Chin J Nat Med. 2018 Aug;16(8):561-571
pubmed: 30197121
Cells. 2012 Aug 13;1(3):520-34
pubmed: 24710488
Proc Nutr Soc. 2012 May;71(2):237-45
pubmed: 22391025
Oncol Lett. 2020 Nov;20(5):167
pubmed: 32934734
Cancer Chemother Pharmacol. 2006 Feb;57(3):376-88
pubmed: 16021489
Melanoma Res. 2011 Jun;21(3):188-95
pubmed: 21537144
Oncotarget. 2017 Sep 6;8(47):82842-82853
pubmed: 29137307
Br J Radiol. 2016;89(1058):20150665
pubmed: 26607642
Cell Signal. 2010 Oct;22(10):1576-96
pubmed: 20600853
Pharmacol Ther. 2015 May;149:1-123
pubmed: 25435018
Bull Hist Med. 1977 Winter;51(4):516-37
pubmed: 343841
J Clin Invest. 2016 Dec 1;126(12):4417-4429
pubmed: 27775547
Biomed Res Int. 2014;2014:924585
pubmed: 25045712
J Med Chem. 2017 Mar 9;60(5):1620-1637
pubmed: 28074653
Cell. 2011 Nov 11;147(4):742-58
pubmed: 22078876
Oncol Rep. 2014 Jun;31(6):2827-33
pubmed: 24789371
Cell Death Dis. 2014 Apr 10;5:e1169
pubmed: 24722294
Mol Cell. 2014 Jul 17;55(2):238-52
pubmed: 24954904
Exp Cell Res. 1995 Jun;218(2):522-30
pubmed: 7540986
J Med Chem. 2017 Aug 10;60(15):6638-6648
pubmed: 28678485
J Biol Chem. 1995 Dec 1;270(48):28495-8
pubmed: 7499357
World J Surg Oncol. 2014 Oct 11;12:307
pubmed: 25304659
Cancer Biol Ther. 2008 Jul;7(7):1024-32
pubmed: 18414057
J Nutr. 2006 Mar;136(3 Suppl):716S-725S
pubmed: 16484550
Cell Mol Life Sci. 2014 Jan;71(2):331-48
pubmed: 23760205
J Clin Oncol. 2002 Sep 15;20(18 Suppl):39S-41S
pubmed: 12235223
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7987-92
pubmed: 9653127
Cancer Res. 2012 Jan 1;72(1):304-14
pubmed: 22084398
Cancer Biol Ther. 2008 Mar;7(3):468-75
pubmed: 18285700
Cell Death Dis. 2014 Aug 21;5:e1384
pubmed: 25144719
Biochem Biophys Res Commun. 2020 Jun 4;526(3):586-591
pubmed: 32247608
BMC Cancer. 2016 Aug 02;16:578
pubmed: 27485374
J Cell Sci. 2017 Apr 1;130(7):1209-1216
pubmed: 28302910
J Biol Chem. 2004 Jul 30;279(31):32780-5
pubmed: 15173180
Drug Des Devel Ther. 2021 Feb 15;15:577-588
pubmed: 33623367
Phytomedicine. 2012 Aug 15;19(11):977-87
pubmed: 22770743
Phytomedicine. 2017 Oct 15;34:182-190
pubmed: 28899501
Immunol Rev. 2012 Sep;249(1):176-94
pubmed: 22889222
Genes Dev. 2011 May 15;25(10):1010-22
pubmed: 21576262
Autophagy. 2011 Oct;7(10):1159-72
pubmed: 21691147
Am J Health Syst Pharm. 2000 Jun 15;57(12):1121-2
pubmed: 10911509
Cancer Res. 2006 May 1;66(9):4758-65
pubmed: 16651429
Future Med Chem. 2015 Aug;7(12):1535-42
pubmed: 26334206
BMC Cancer. 2015 Mar 18;15:139
pubmed: 25885900
Anticancer Res. 2003 Jan-Feb;23(1A):363-98
pubmed: 12680238
Asian Pac J Cancer Prev. 2014;15(9):3865-71
pubmed: 24935565
Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2503-8
pubmed: 20133800
Breast Cancer Res Treat. 2010 May;121(1):233-40
pubmed: 19760501
J Nutr Sci Vitaminol (Tokyo). 2014;60(2):122-8
pubmed: 24975222
Curr Opin Cell Biol. 2010 Apr;22(2):132-9
pubmed: 20056399
AAPS J. 2015 Jul;17(4):802-12
pubmed: 25840885
Front Oncol. 2015 May 11;5:105
pubmed: 26029662
Asian Pac J Cancer Prev. 2014;15(24):10557-63
pubmed: 25605139
Cancer Cell Int. 2015 Jul 15;15:71
pubmed: 26180516
Semin Cell Dev Biol. 2014 Nov;35:24-32
pubmed: 24582829
Carcinogenesis. 2008 Feb;29(2):381-9
pubmed: 18048384
Medicine (Baltimore). 2020 Jan;99(2):e18467
pubmed: 31914018
Tumour Biol. 2014 Aug;35(8):8065-75
pubmed: 24839007
Trends Biochem Sci. 2016 Mar;41(3):211-218
pubmed: 26778478
Nat Rev Cancer. 2007 Jul;7(7):554-62
pubmed: 17585335
Phytomedicine. 2015 May 15;22(5):536-44
pubmed: 25981919
BMC Cancer. 2013 Dec 06;13:580
pubmed: 24314238
AAPS J. 2009 Sep;11(3):495-510
pubmed: 19590964
Cancer Treat Rev. 2009 Nov;35(7):597-607
pubmed: 19660870
Cell Death Dis. 2015 Dec 03;6:e2003
pubmed: 26633709
J Nat Prod. 2014 Feb 28;77(2):370-6
pubmed: 24547878
Arch Oral Biol. 2012 Aug;57(8):1018-25
pubmed: 22554995
Biochem Biophys Res Commun. 2015 Jun 19;462(1):38-45
pubmed: 25935480
J Cell Mol Med. 2011 Sep;15(9):1797-806
pubmed: 21564515
Int J Gynecol Cancer. 2013 Jun;23(5):803-8
pubmed: 23532091
Ann Surg Oncol. 2011 Apr;18(4):912-6
pubmed: 21225354
Front Pharmacol. 2016 Jul 12;7:201
pubmed: 27462269
Pharmacogn Rev. 2011 Jan;5(9):1-12
pubmed: 22096313
Cancer Lett. 2016 Jan 1;370(1):153-64
pubmed: 26499806
BMC Cancer. 2009 Jun 30;9:215
pubmed: 19566920
Apoptosis. 2015 Jan;20(1):92-109
pubmed: 25398540
Autophagy. 2007 Nov-Dec;3(6):635-7
pubmed: 17786026
Nat Cell Biol. 2006 Oct;8(10):1045-7
pubmed: 17013414
Anticancer Agents Med Chem. 2012 Oct 1;12(8):891-901
pubmed: 22292765
Biochem Pharmacol. 2011 Mar 1;81(5):606-16
pubmed: 21182827
Curr Oncol Rep. 2002 Jan;4(1):37-46
pubmed: 11734112
Autophagy. 2010 Jul;6(5):655-7
pubmed: 20458181
Nature. 1983 Feb 17-23;301(5901):621-3
pubmed: 6828143
PLoS One. 2011;6(11):e27892
pubmed: 22132163
Carcinogenesis. 2008 Dec;29(12):2360-8
pubmed: 18952594
Cancer Res. 2004 Jul 15;64(14):4849-57
pubmed: 15256455
Mol Carcinog. 2016 May;55(5):818-31
pubmed: 25917875
Cancer Cell Int. 2013 Feb 23;13(1):19
pubmed: 23432995
Adv Exp Med Biol. 2007;595:77-103
pubmed: 17569206
PLoS One. 2012;7(10):e46749
pubmed: 23056433
Cell Mol Life Sci. 2017 Mar;74(5):777-801
pubmed: 27622244
Asian Pac J Cancer Prev. 2013;14(12):7537-42
pubmed: 24460330
J Cancer Res Clin Oncol. 2013 Mar;139(3):357-65
pubmed: 23099993
Sci Rep. 2015 Mar 30;5:9301
pubmed: 25818003
Biomed Pharmacother. 2016 Oct;83:79-84
pubmed: 27470553
J Mol Biol. 2019 Jan 18;431(2):258-272
pubmed: 30428301
Mol Cancer Res. 2007 Mar;5(3):241-9
pubmed: 17374730
Drug Resist Updat. 2020 May;50:100682
pubmed: 32087558
Cancer Lett. 1992 Feb 14;62(1):69-75
pubmed: 1347251
Breast Cancer Res Treat. 2017 Jul;164(2):359-369
pubmed: 28439738
Med Res Rev. 2000 Sep;20(5):323-49
pubmed: 10934347
Mol Ther Nucleic Acids. 2020 Mar 6;19:877-889
pubmed: 31982774
Nat Prod Rep. 2015 Feb;32(2):256-72
pubmed: 25347695
Acta Pharm Sin B. 2019 Jul;9(4):659-674
pubmed: 31384528
PLoS One. 2015 May 22;10(5):e0127386
pubmed: 26000607
Anticancer Agents Med Chem. 2013 Sep;13(7):1048-56
pubmed: 23293890
Cancer Discov. 2013 Aug;3(8):894-907
pubmed: 23650262
Annu Rev Med. 2014;65:139-55
pubmed: 24188661
Food Funct. 2019 Jun 19;10(6):3748-3757
pubmed: 31172987
Autophagy. 2012 May 1;8(5):812-25
pubmed: 22622204
Nature. 2010 Jul 1;466(7302):68-76
pubmed: 20562859
Dev Cell. 2016 May 23;37(4):337-349
pubmed: 27219062
Blood. 2009 Jun 4;113(23):5927-37
pubmed: 19190249
Cell Mol Biol (Noisy-le-grand). 2018 May 15;64(6):17-22
pubmed: 29808795
Ann Med Health Sci Res. 2012 Jul;2(2):191-8
pubmed: 23439914
Mol Cancer Ther. 2006 Aug;5(8):1995-2006
pubmed: 16928820
Oncotarget. 2014 Jun 30;5(12):4438-51
pubmed: 24970805
Apoptosis. 2009 May;14(5):674-86
pubmed: 19288276
Int J Oncol. 2012 Apr;40(4):1020-8
pubmed: 22218562
Acta Pharmacol Sin. 2012 Dec;33(12):1542-8
pubmed: 23064721
BMB Rep. 2014 Dec;47(12):697-702
pubmed: 24667175
Biochim Biophys Acta. 2013 May;1832(5):606-17
pubmed: 23376112
Clin Epigenetics. 2017 Feb 10;9:17
pubmed: 28203307
Phytomedicine. 2018 Nov 15;50:213-222
pubmed: 30466981
Cell. 2015 Jul 16;162(2):259-270
pubmed: 26144316
Cancer Sci. 2008 Jan;99(1):121-8
pubmed: 17953712
Immunity. 2013 Aug 22;39(2):211-27
pubmed: 23973220
Cell Death Dis. 2014 May 08;5:e1216
pubmed: 24810052
Autophagy. 2013 Mar;9(3):424-5
pubmed: 23321721
Cancer. 2005 Sep 15;104(6):1322-31
pubmed: 16092118
Int J Mol Med. 2013 Dec;32(6):1227-38
pubmed: 24126942
Mol Pharmacol. 2007 Jul;72(1):29-39
pubmed: 17395690
Autophagy. 2011 Sep;7(9):1035-44
pubmed: 21646864
Cancer Chemother Pharmacol. 2018 Mar;81(3):587-596
pubmed: 29392450
Nat Cell Biol. 2018 Mar;20(3):233-242
pubmed: 29476151
Biochem Pharmacol. 2004 Nov 15;68(10):2043-52
pubmed: 15476675
J Immunother. 2013 Nov-Dec;36(9):477-89
pubmed: 24145359
Eur J Med Chem. 2019 Dec 1;183:111706
pubmed: 31553932
Cell. 2016 Mar 10;164(6):1226-1232
pubmed: 26967288
Oncol Res. 2020 Dec 10;28(5):533-540
pubmed: 32532363
Cell Death Dis. 2013 Oct 31;4:e891
pubmed: 24176849
Antioxidants (Basel). 2021 Apr 29;10(5):
pubmed: 33946704
Cell Death Differ. 2013 Sep;20(9):1161-73
pubmed: 23744296
Pharm Res. 2009 Feb;26(2):480-7
pubmed: 18841445
Int J Oncol. 2010 Oct;37(4):821-8
pubmed: 20811703
Chin Med. 2010 Jul 25;5:26
pubmed: 20653978
Oncogene. 2003 May 22;22(21):3330-42
pubmed: 12761503
Cancer Sci. 2008 Sep;99(9):1813-9
pubmed: 18616529
PLoS One. 2014 Jan 29;9(1):e87161
pubmed: 24489859
Front Oncol. 2021 Jan 19;10:570108
pubmed: 33542897
Biomol Ther (Seoul). 2014 May;22(3):167-75
pubmed: 25009696
Cold Spring Harb Perspect Biol. 2012 Jan 01;4(1):a008821
pubmed: 22166310
Nat Rev Mol Cell Biol. 2014 Feb;15(2):81-94
pubmed: 24401948
Oncotarget. 2015 Apr 20;6(11):8635-47
pubmed: 25888634
J Ethnopharmacol. 2017 May 5;203:110-119
pubmed: 28363522
Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):201-205
pubmed: 28039434
Biochim Biophys Acta. 2006 Sep-Oct;1757(9-10):1371-87
pubmed: 16950166
Tumour Biol. 2014 Jun;35(6):5111-9
pubmed: 24526416
J Clin Oncol. 2004 Dec 1;22(23):4810-5
pubmed: 15570083
Pathol Res Pract. 2017 Jul;213(7):848-853
pubmed: 28554760
Am J Pathol. 2010 May;176(5):2477-89
pubmed: 20382705
Oncol Lett. 2016 Nov;12(5):3739-3748
pubmed: 27895725
Acta Biochim Biophys Sin (Shanghai). 2015 Oct;47(10):824-33
pubmed: 26341980
Int J Toxicol. 2007 Jul-Aug;26(4):279-88
pubmed: 17661218
Pharmazie. 2019 Jun 1;74(6):363-368
pubmed: 31138375
Sci Rep. 2015 Jul 23;5:12291
pubmed: 26201611
Mol Med Rep. 2014 Sep;10(3):1315-22
pubmed: 25060817
Cancer Res. 2019 Apr 15;79(8):1884-1898
pubmed: 30765601
Curr Med Chem. 2006;13(16):1859-76
pubmed: 16842198
Anticancer Agents Med Chem. 2018;18(9):1330-1337
pubmed: 30088453
Development. 1989 Nov;107(3):597-604
pubmed: 2612378
Biochim Biophys Acta. 2010 Dec;1806(2):220-9
pubmed: 20637264
Korean J Physiol Pharmacol. 2011 Feb;15(1):1-7
pubmed: 21461234
J Palliat Med. 2013 Nov;16(11):1466-76
pubmed: 24102459
Chembiochem. 2011 Jan 24;12(2):206-22
pubmed: 21243710
Cancer Res. 2006 Jun 1;66(11):5828-35
pubmed: 16740722
Nat Immunol. 2000 Dec;1(6):489-95
pubmed: 11101870
Cancer Lett. 2014 Jun 1;347(2):159-66
pubmed: 24657660
Chin J Nat Med. 2021 Feb;19(2):143-152
pubmed: 33641785
Phytomedicine. 2019 Feb 15;54:140-148
pubmed: 30668363
Cell. 2008 May 16;133(4):693-703
pubmed: 18485876
ChemMedChem. 2013 May;8(5):694-707
pubmed: 23568434
Science. 2009 May 22;324(5930):1029-33
pubmed: 19460998
Oncol Rep. 2019 Oct;42(4):1259-1271
pubmed: 31524243
Asian Pac J Cancer Prev. ;18(2):507-513
pubmed: 28345838
Clin Pharmacokinet. 2012 Feb 1;51(2):77-104
pubmed: 22257149
J Biomed Biotechnol. 2009;2009:742936
pubmed: 20168983
Clin Cancer Res. 2008 Jul 15;14(14):4491-9
pubmed: 18628464
Am J Chin Med. 2017;45(2):385-401
pubmed: 28231742
Cell Res. 2007 Apr;17(4):311-23
pubmed: 17404598
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Dec;21(6):1413-22
pubmed: 24370022
Oncotarget. 2015 Oct 20;6(32):33046-64
pubmed: 26426994
Cell Death Discov. 2017 Jan 23;3:16096
pubmed: 28179994
Mol Pharm. 2007 Nov-Dec;4(6):807-18
pubmed: 17999464
Life Sci. 2005 Dec 22;78(5):431-41
pubmed: 16198377
Bioorg Med Chem Lett. 2016 Mar 1;26(5):1495-7
pubmed: 26865176
Int J Mol Sci. 2020 Jan 08;21(2):
pubmed: 31936346
Cancer. 2016 Feb 15;122(4):598-610
pubmed: 26599199
Cancer Res. 2002 Mar 15;62(6):1815-21
pubmed: 11912160
Mol Cancer. 2015 Feb 21;14:48
pubmed: 25743109
Phytomedicine. 2020 Dec;79:153342
pubmed: 32992085
Sci Rep. 2021 Jan 19;11(1):1788
pubmed: 33469044
Cell Cycle. 2003 Jul-Aug;2(4):377-83
pubmed: 12851492
Phytomedicine. 2019 Jul;60:152832
pubmed: 31031043
Zhong Xi Yi Jie He Xue Bao. 2011 May;9(5):525-30
pubmed: 21565138
Daru. 2020 Dec;28(2):701-734
pubmed: 32803687
Int J Oncol. 2012 Apr;40(4):1066-70
pubmed: 22139090
Biochim Biophys Acta. 2016 Apr;1865(2):228-36
pubmed: 26968619
PLoS One. 2011;6(6):e18691
pubmed: 21655094
Cancer Epidemiol Biomarkers Prev. 2008 Jul;17(7):1596-610
pubmed: 18628411
Front Endocrinol (Lausanne). 2018 Aug 03;9:402
pubmed: 30123182
Histochem Cell Biol. 2012 Jan;137(1):25-36
pubmed: 21993664
J Pathol. 2008 Feb;214(3):283-93
pubmed: 18095256
Cell Death Dis. 2014 Nov 06;5:e1509
pubmed: 25375374
Mol Med Today. 2000 Apr;6(4):157-62
pubmed: 10740254
Planta Med. 2015 Jan;81(1):79-89
pubmed: 25478784
Cancer Chemother Pharmacol. 2013 Jun;71(6):1521-30
pubmed: 23543271
Gastroenterology. 2010 Aug;139(2):598-608
pubmed: 20434451
Molecules. 2018 Feb 11;23(2):
pubmed: 29439483
N Engl J Med. 2006 Sep 7;355(10):983-91
pubmed: 16957145
Oncogene. 2008 Mar 27;27(14):2055-63
pubmed: 17998943
Cell. 1992 Aug 7;70(3):401-10
pubmed: 1643658
Oncotarget. 2017 Sep 8;8(44):76656-76665
pubmed: 29100339
Int J Mol Sci. 2018 Feb 02;19(2):
pubmed: 29393886
Biotechnol Adv. 2015 Dec;33(8):1582-1614
pubmed: 26281720
Biochemistry. 1997 Sep 2;36(35):10709-17
pubmed: 9271501
Phytomedicine. 2011 Jun 15;18(8-9):697-703
pubmed: 21239154
Molecules. 2018 Oct 22;23(10):
pubmed: 30360404
J Appl Physiol (1985). 2000 Apr;88(4):1474-80
pubmed: 10749844
Ann Hepatol. 2017 Aug 1;16(4):607-618
pubmed: 28611265
J Biochem Mol Toxicol. 2007;21(4):163-8
pubmed: 17936929
Adv Exp Med Biol. 2019;1141:549-580
pubmed: 31571174
Cell Death Dis. 2013 Sep 12;4:e802
pubmed: 24030154
Autophagy. 2014 May;10(5):736-49
pubmed: 24642486
Front Oncol. 2019 Jun 11;9:476
pubmed: 31263672
Mol Pharmacol. 2001 May;59(5):1171-80
pubmed: 11306701
Autophagy. 2010 Apr;6(3):322-9
pubmed: 20224296
Int J Dev Biol. 2015;59(1-3):5-9
pubmed: 26374520
Cancer Res. 2007 Dec 15;67(24):11848-58
pubmed: 18089815
Bioorg Med Chem Lett. 2004 Mar 8;14(5):1193-6
pubmed: 14980663
Anticancer Agents Med Chem. 2017;17(2):164-170
pubmed: 27804847
Food Chem Toxicol. 1999 Sep-Oct;37(9-10):973-9
pubmed: 10541453
J Mol Signal. 2010 Aug 18;5:14
pubmed: 20718984
Nat Rev Drug Discov. 2013 Nov;12(11):847-65
pubmed: 24172333
Blood. 2013 Apr 4;121(14):2689-703
pubmed: 23393050
Phytomedicine. 2020 Oct;77:153280
pubmed: 32712543
Chem Biol Interact. 2013 Sep 25;205(2):119-27
pubmed: 23811387
Phytother Res. 2020 Oct;34(10):2534-2556
pubmed: 32307747
Asian Pac J Cancer Prev. 2012;13(2):427-36
pubmed: 22524801
J Biol Chem. 1995 Mar 17;270(11):5830-8
pubmed: 7890712
Nat Prod Rep. 2009 Aug;26(8):1001-43
pubmed: 19636448
Blood. 2012 Aug 9;120(6):1262-73
pubmed: 22740450
Oncol Lett. 2020 Jan;19(1):83-92
pubmed: 31897118
Oncotarget. 2017 May 2;8(18):29760-29770
pubmed: 28423656
Acta Pharmacol Sin. 2002 Dec;23(12):1102-6
pubmed: 12466047
J Immunol. 1988 Oct 15;141(8):2629-34
pubmed: 3171180
Cell Death Dis. 2015 Jan 22;6:e1604
pubmed: 25611379
PLoS One. 2013 Jun 28;8(6):e66326
pubmed: 23840441
Oncotarget. 2016 Apr 12;7(15):20293-304
pubmed: 26934122
PLoS One. 2011;6(6):e20849
pubmed: 21695150
Dev Cell. 2015 Mar 23;32(6):678-92
pubmed: 25752962
Cancer J. 2003 Jan-Feb;9(1):33-41
pubmed: 12602766
Nature. 2017 Jan 11;541(7636):144-145
pubmed: 28079090
Integr Cancer Ther. 2003 Mar;2(1):13-33
pubmed: 12941165
J Chromatogr Sep Tech. 2013 Jan 1;4(1):
pubmed: 24482742
Adv Exp Med Biol. 2014;772:167-88
pubmed: 24272359
Nutr Cancer. 2011;63(7):1104-13
pubmed: 21916706
Sci Rep. 2018 Feb 22;8(1):3446
pubmed: 29472576
Biomed Res Int. 2014;2014:150845
pubmed: 25013758
Oncogene. 2016 Jan 7;35(1):1-11
pubmed: 25893285
AAPS PharmSciTech. 2020 Apr 26;21(4):121
pubmed: 32337630
J Agric Food Chem. 2019 Mar 6;67(9):2510-2518
pubmed: 30741544
Annu Rev Pharmacol Toxicol. 2001;41:53-77
pubmed: 11264450
Cell Prolif. 2012 Oct;45(5):466-76
pubmed: 22765290
Altern Med Rev. 2009 Jun;14(2):141-53
pubmed: 19594223
Biochem Biophys Res Commun. 2011 Mar 25;406(4):497-500
pubmed: 21329660
Fundam Clin Pharmacol. 2020 Apr;34(2):192-199
pubmed: 31808968
J Biol Inorg Chem. 2013 Feb;18(2):165-74
pubmed: 23183891
Nat Immun. 1998;16(1):27-33
pubmed: 9789122
Cell Death Dis. 2013 May 02;4:e622
pubmed: 23640464
Int J Mol Sci. 2013 Jun 05;14(6):12023-36
pubmed: 23739680
Phytomedicine. 2019 Feb;53:252-262
pubmed: 30668405
JCI Insight. 2019 Aug 8;4(15):
pubmed: 31391333
Nat Rev Cancer. 2008 Mar;8(3):193-204
pubmed: 18256616
Clin Oncol (R Coll Radiol). 2012 Aug;24(6):387-95
pubmed: 22032864
Curr Drug Targets. 2011 Dec;12(13):1925-56
pubmed: 21158707
Cell Death Dis. 2016 Dec 8;7(12):e2512
pubmed: 27929538
J Asian Nat Prod Res. 2009 Nov;11(11):918-28
pubmed: 20183254
Int J Mol Sci. 2020 May 02;21(9):
pubmed: 32370233
Cancer Discov. 2014 Jul;4(7):773-80
pubmed: 24823863
Anticancer Drugs. 2012 Oct;23(9):883-96
pubmed: 22797176
J Ethnopharmacol. 2021 Jan 10;264:113388
pubmed: 32918990
Autophagy. 2008 May;4(4):510-2
pubmed: 18376150
Adv Virol. 2012;2012:805347
pubmed: 22500169
J Biol Chem. 2001 May 11;276(19):16076-82
pubmed: 11279022
Nat Cell Biol. 2015 Apr;17(4):434-44
pubmed: 25751141
Onco Targets Ther. 2019 Jul 17;12:5751-5765
pubmed: 31410021
Nat Rev Cancer. 2017 Sep;17(9):528-542
pubmed: 28751651
Sci Rep. 2019 Jan 23;9(1):378
pubmed: 30674943
Cancer Res. 2010 Feb 1;70(3):1042-52
pubmed: 20103647
Int J Radiat Oncol Biol Phys. 2008 Feb 1;70(2):529-42
pubmed: 18207031
Crit Rev Clin Lab Sci. 2006;43(2):143-81
pubmed: 16517421
Front Oncol. 2020 Jan 17;9:1547
pubmed: 32010632
Cancer Lett. 2009 Feb 18;274(2):233-42
pubmed: 19027226
Cell Death Differ. 2014 Jan;21(1):92-9
pubmed: 24037090
Dev Cell. 2019 Apr 8;49(1):130-144.e6
pubmed: 30827897
Eur J Med Chem. 2020 Jul 15;198:112331
pubmed: 32403017
Adv Exp Med Biol. 1998;439:191-225
pubmed: 9781305
Rev Neurosci. 2019 Jul 26;30(5):527-541
pubmed: 30645197
Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14687-92
pubmed: 25271322
Eur J Med Chem. 2019 Jun 15;172:71-94
pubmed: 30947123
Cell Growth Differ. 1991 Apr;2(4):209-14
pubmed: 1651102
Cell Death Differ. 2012 Aug;19(8):1337-46
pubmed: 22343715
PLoS One. 2011;6(9):e25268
pubmed: 21966475
PLoS One. 2014 Jan 21;9(1):e85771
pubmed: 24465696
Neoplasia. 2016 Jun;18(6):347-55
pubmed: 27292024
IUBMB Life. 2007 Dec;59(12):752-7
pubmed: 18085475
Phytomedicine. 2016 Mar 15;23(3):316-23
pubmed: 26969385
Trends Mol Med. 2018 Mar;24(3):257-277
pubmed: 29449148
Nature. 2019 Apr;568(7752):410-414
pubmed: 30918400
Cytokine Growth Factor Rev. 2014 Apr;25(2):157-65
pubmed: 24411566
Nature. 2013 Dec 12;504(7479):296-300
pubmed: 24305049
Int J Mol Sci. 2008 Jun;9(6):1096-107
pubmed: 19325847
Int J Biochem Cell Biol. 2018 Nov;104:114-132
pubmed: 30266524
Curr Pharm Des. 2013;19(40):7126-40
pubmed: 23829373
BMC Complement Altern Med. 2006 Mar 17;6:10
pubmed: 16545122
Diagn Pathol. 2013 Dec 10;8:198
pubmed: 24326092
Nat Commun. 2020 Feb 28;11(1):1120
pubmed: 32111838
Planta Med. 2013 Dec;79(18):1685-97
pubmed: 24155261
Cancer Chemother Pharmacol. 2018 Oct;82(4):695-706
pubmed: 30074076
Anticancer Drugs. 2021 Oct 1;32(9):939-949
pubmed: 34001704
Cancer Discov. 2018 Jul;8(7):866-883
pubmed: 29572236
Life Sci. 2006 Mar 27;78(18):2116-30
pubmed: 16455109
J Clin Oncol. 2001 Sep 15;19(18):3852-60
pubmed: 11559723
Mol Cell. 2008 Jun 20;30(6):689-700
pubmed: 18570872
J Korean Med Sci. 2001 Dec;16 Suppl:S6-18
pubmed: 11748383
Microb Cell. 2016 Dec 01;3(12):588-596
pubmed: 28357331
Mol Biol Rep. 2015 Sep;42(9):1419-29
pubmed: 26311153
Curr Pharm Des. 2014;20(5):793-807
pubmed: 23688078
J Immunother Cancer. 2016 May 17;4:25
pubmed: 27190627
Tumour Biol. 2015 Dec;36(12):9311-7
pubmed: 26104765
Br J Pharmacol. 2011 Sep;164(2b):731-42
pubmed: 21418191
Phytomedicine. 2014 Oct 15;21(12):1658-65
pubmed: 25442274
Cytometry A. 2003 Aug;54(2):118-24
pubmed: 12879458
Cancer Sci. 2012 Apr;103(4):684-90
pubmed: 22192169
Oncol Res. 2020 Mar 27;28(2):177-189
pubmed: 31771696
Cancer Lett. 2008 Feb 8;259(2):127-37
pubmed: 18082322
J Agric Food Chem. 2012 Jun 13;60(23):5693-708
pubmed: 22300613
Phytother Res. 2016 Aug;30(8):1207-18
pubmed: 27188216
Int J Cancer. 2000 Feb 1;85(3):438-45
pubmed: 10652438
Autophagy. 2015;11(2):225-38
pubmed: 25607466
J Exp Clin Cancer Res. 2017 Aug 10;36(1):107
pubmed: 28797284
Front Oncol. 2020 Mar 05;10:265
pubmed: 32195185
Oncology. 2016;90(2):69-78
pubmed: 26771576
Molecules. 2019 Jun 25;24(12):
pubmed: 31242603
Pure Appl Chem. 2009 Jan 1;81(6):1051-1063
pubmed: 20046887
In Vitro Cell Dev Biol Anim. 2015 Nov;51(10):1033-9
pubmed: 26091630
Oncol Rep. 2015 Jun;33(6):2711-8
pubmed: 25891311
Oncotarget. 2017 Sep 23;8(50):87860-87877
pubmed: 29152126
Biosci Biotechnol Biochem. 2009 Oct;73(10):2183-9
pubmed: 19809182
Evid Based Complement Alternat Med. 2015;2015:767136
pubmed: 26421052
Nat Cell Biol. 2010 Sep;12(9):814-22
pubmed: 20811353
J Cell Mol Med. 2007 Nov-Dec;11(6):1214-24
pubmed: 18031301
J Cell Physiol. 2003 Dec;197(3):312-25
pubmed: 14566961
Oncol Rep. 2018 Nov;40(5):2758-2765
pubmed: 30132535
Chin J Nat Med. 2014 Dec;12(12):881-94
pubmed: 25556059
J Biol Chem. 2005 Feb 25;280(8):6561-9
pubmed: 15611046
Oncol Rep. 2013 Sep;30(3):1119-28
pubmed: 23765060
Autophagy. 2009 Apr;5(3):430-1
pubmed: 19202353
Biochem Soc Trans. 2016 Jun 15;44(3):824-30
pubmed: 27284047
J Exp Clin Cancer Res. 2019 Mar 29;38(1):139
pubmed: 30922391
Clin Cancer Res. 2006 Aug 1;12(15):4523-32
pubmed: 16899598
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Dec;21(12):885-7
pubmed: 12575585
J Agric Food Chem. 2013 Oct 16;61(41):9839-48
pubmed: 24059278
Eur J Pharm Sci. 2009 Jun 28;37(3-4):223-30
pubmed: 19491009
Eur J Cancer. 1996 Jun;32A(6):967-78
pubmed: 8763337
Nature. 2013 May 30;497(7451):633-7
pubmed: 23665962
Int J Oncol. 2019 Jun;54(6):1995-2004
pubmed: 31081045
Eur J Pharmacol. 2010 Apr 10;631(1-3):1-9
pubmed: 20056115
Nature. 2001 Nov 1;414(6859):105-11
pubmed: 11689955
PLoS One. 2016 May 12;11(5):e0155013
pubmed: 27171227
AAPS J. 2015 Jan;17(1):65-82
pubmed: 25236865
Front Pharmacol. 2019 Jun 26;10:722
pubmed: 31293428
Chem Biol Interact. 2018 Jan 25;280:45-50
pubmed: 29191453
Cancer Lett. 2017 Apr 10;391:89-99
pubmed: 28131906
Chem Rev. 2014 Mar 12;114(5):2881-941
pubmed: 24576227
Chest. 2011 Jul;140(1):127-134
pubmed: 21148243
Cancer Drug Resist. 2019;2:141-160
pubmed: 34322663
Semin Cancer Biol. 2015 Dec;35 Suppl:S78-S103
pubmed: 25936818
Molecules. 2018 Feb 06;23(2):
pubmed: 29415493
Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20054-9
pubmed: 22123964
Trends Cell Biol. 1995 Nov;5(11):424-8
pubmed: 14732047
Adv Exp Med Biol. 2007;595:127-48
pubmed: 17569208
J Agric Food Chem. 2010 Apr 14;58(7):3957-64
pubmed: 20025272
J Med Food. 2010 Dec;13(6):1415-23
pubmed: 20946021
Anticancer Agents Med Chem. 2012 Oct 1;12(8):880-90
pubmed: 22583399
Curr Med Chem. 2011;18(8):1100-21
pubmed: 21291372
Oncol Rep. 2015 Aug;34(2):547-54
pubmed: 26044950
Med Sci Monit. 2018 Oct 20;24:7482-7492
pubmed: 30341887
Cancer Res. 2012 Jul 15;72(14):3535-45
pubmed: 22745370
Oncol Lett. 2021 Mar;21(3):230
pubmed: 33613719
IUBMB Life. 2020 May;72(5):855-871
pubmed: 31913572
Front Pharmacol. 2020 Oct 06;11:529881
pubmed: 33117153
J Nutr. 2004 Sep;134(9):2229-36
pubmed: 15333709
Am J Pathol. 2014 Jun;184(6):1630-42
pubmed: 24726643
Oncogene. 2005 Apr 28;24(19):3166-76
pubmed: 15735693
Gastroenterology. 2007 Jun;132(7):2557-76
pubmed: 17570226
J Biol Chem. 2008 Aug 8;283(32):22136-46
pubmed: 18524779
Autophagy. 2008 Nov;4(8):1083-5
pubmed: 18849663
Breast Cancer. 2018 Mar;25(2):233-242
pubmed: 29181822
Expert Opin Investig Drugs. 2012 Dec;21(12):1801-18
pubmed: 23092199
Cancer Cell Int. 2016 Aug 02;16:62
pubmed: 27486382
Hematol Rep. 2012 Jul 11;4(3):e18
pubmed: 23087807
Genes Dev. 2009 Apr 1;23(7):781-3
pubmed: 19339683
Mol Cancer Res. 2016 Nov;14(11):1087-1096
pubmed: 27578770
Int J Mol Sci. 2021 Jun 30;22(13):
pubmed: 34209254
Drug Discov Today. 2010 Aug;15(15-16):668-78
pubmed: 20541036
Mol Cancer Res. 2008 Jun;6(6):965-77
pubmed: 18567800
Mol Cancer. 2018 Feb 19;17(1):58
pubmed: 29455648
Br J Cancer. 1993 Aug;68(2):235-9
pubmed: 8347477
Cell Biol Int. 2019 Jun;43(6):582-592
pubmed: 30958602
Mol Cancer Ther. 2017 Jun;16(6):1155-1165
pubmed: 28246302
Cancer Biol Ther. 2015;16(7):1005-13
pubmed: 25985143
Cancer Res. 2014 Feb 15;74(4):1056-66
pubmed: 24371227
Cancer Lett. 2014 Sep 1;351(2):242-51
pubmed: 24973521
Autophagy. 2011 Sep;7(9):966-78
pubmed: 21610320
Biomolecules. 2019 Nov 01;9(11):
pubmed: 31683894
Oncotarget. 2015 Feb 10;6(4):1995-2008
pubmed: 25575821
PLoS One. 2015 Jun 11;10(6):e0129196
pubmed: 26067645
Immunol Rev. 2017 May;277(1):76-89
pubmed: 28462525
Chin J Cancer. 2011 Jul;30(7):490-6
pubmed: 21718595
Curr Drug Discov Technol. 2010 Mar;7(1):67-75
pubmed: 20226002
Trends Biochem Sci. 2007 Jan;32(1):37-43
pubmed: 17141506
Cell. 2007 Sep 7;130(5):765-8
pubmed: 17803897
Nat Chem Biol. 2005 Jul;1(2):112-9
pubmed: 16408008
Biomed Res Int. 2014;2014:530342
pubmed: 25379508
Eur J Pharm Sci. 2011 Jun 14;43(3):125-31
pubmed: 21514382
Asian Pac J Cancer Prev. 2012;13(10):4867-71
pubmed: 23244072
Invest New Drugs. 2015 Feb;33(1):1-11
pubmed: 25200916
Eur J Pharmacol. 2021 Mar 5;894:173817
pubmed: 33345849
Expert Opin Drug Metab Toxicol. 2010 Feb;6(2):153-70
pubmed: 20078251
Molecules. 2021 Apr 25;26(9):
pubmed: 33923028
Phytomedicine. 2019 Mar 1;55:269-281
pubmed: 30668439
Cell Death Dis. 2013 Oct 10;4:e838
pubmed: 24113172
Carcinogenesis. 2015 Jun;36 Suppl 1:S61-88
pubmed: 26106144
Bioorg Chem. 2019 Oct;91:103091
pubmed: 31319298
Biochem Cell Biol. 2020 Aug;98(4):484-491
pubmed: 31967866
Toxins (Basel). 2020 Nov 26;12(12):
pubmed: 33256185
Cancer Lett. 2015 Oct 28;367(2):108-12
pubmed: 26231733
Photochem Photobiol. 2012 Sep-Oct;88(5):1165-72
pubmed: 22272775
Int J Oncol. 2014 Apr;44(4):1233-42
pubmed: 24535083
Cancer Biol Ther. 2012 Sep;13(11):978-91
pubmed: 22825332
Int J Oncol. 2014 Oct;45(4):1329-36
pubmed: 25175943
Nat Chem Biol. 2016 Jul;12(7):497-503
pubmed: 27159577
Pharmacol Ther. 2011 Jul;131(1):130-41
pubmed: 21440002
Thorac Cancer. 2015 Sep;6(5):561-9
pubmed: 26445604
Neuroreport. 2019 Dec 10;30(17):1191-1196
pubmed: 31634239
Br J Cancer. 2005 Jul 25;93(2):216-23
pubmed: 15999103
Acta Pharmacol Sin. 2014 Jul;35(7):929-36
pubmed: 24909514
Semin Cell Dev Biol. 2014 Nov;35:14-23
pubmed: 25087983
Cancer Lett. 2015 Jul 28;363(2):101-7
pubmed: 25896632
Curr Cancer Drug Targets. 2015;15(8):684-702
pubmed: 26452384
Chin Med Sci J. 2012 Jun;27(2):65-72
pubmed: 22770403
Drug Resist Updat. 2015 Jan;18:1-17
pubmed: 25554624
Food Chem Toxicol. 2019 Jun;128:240-255
pubmed: 30991130
Mol Pharm. 2020 Apr 6;17(4):1415-1427
pubmed: 32159961
Genes Dis. 2019 Nov 02;7(3):370-379
pubmed: 32884991
J Invest Dermatol. 2015 Jun;135(6):1629-1637
pubmed: 25674907
PLoS One. 2015 Oct 16;10(10):e0140745
pubmed: 26473737
Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10210-26
pubmed: 27488942
Apoptosis. 2015 Dec;20(12):1531-62
pubmed: 26362468
Phytomedicine. 2020 Jun;71:153239
pubmed: 32447245
Methods Mol Biol. 2016;1395:1-18
pubmed: 26910065
Ther Deliv. 2011 Oct;2(10):1275-93
pubmed: 22826883
Chin Med J (Engl). 2013;126(9):1642-6
pubmed: 23652044
Mol Cancer Ther. 2007 May;6(5):1641-9
pubmed: 17513612
Physiol Rev. 2010 Oct;90(4):1383-435
pubmed: 20959619
Acta Pharm Sin B. 2020 Apr;10(4):569-581
pubmed: 32322463
Expert Rev Anticancer Ther. 2006 Nov;6(11):1559-68
pubmed: 17134361
Mol Pharmacol. 2010 Nov;78(5):855-64
pubmed: 20713551
Annu Rev Biochem. 1989;58:351-75
pubmed: 2549853
Invest New Drugs. 2010 Oct;28(5):670-6
pubmed: 19565187
Molecules. 2020 Sep 18;25(18):
pubmed: 32961987
Anticancer Res. 2001 Jul-Aug;21(4B):2895-900
pubmed: 11712783
Environ Mol Mutagen. 2017 Jun;58(5):235-263
pubmed: 28485537
Chem Res Toxicol. 2008 Jan;21(1):70-83
pubmed: 18052394
J Exp Clin Cancer Res. 2018 Feb 23;37(1):37
pubmed: 29475441
J Exp Clin Cancer Res. 2014 Apr 28;33:37
pubmed: 24775603
Annu Rev Med. 2002;53:615-27
pubmed: 11818492
Adv Immunol. 2013;119:135-53
pubmed: 23886067
Oxid Med Cell Longev. 2020 May 21;2020:6841581
pubmed: 32566095
Cancer Prev Res (Phila). 2013 Jan;6(1):27-39
pubmed: 23248098
Stem Cells Dev. 2013 Feb 15;22(4):554-66
pubmed: 22974371
Anticancer Res. 1999 Nov-Dec;19(6B):5229-33
pubmed: 10697540
Chin Med. 2011 Jul 22;6(1):27
pubmed: 21777476
Eur J Nutr. 2013 Dec;52(8):1949-58
pubmed: 23389114
J Natl Cancer Inst. 2004 Jun 16;96(12):946-56
pubmed: 15199114
Int J Cancer. 2012 Sep 15;131(6):1445-54
pubmed: 22116711
Autophagy. 2011 Dec;7(12):1448-61
pubmed: 22082875
Oncotarget. 2015 Jan 20;6(2):789-801
pubmed: 25596736
Science. 1992 Oct 23;258(5082):607-14
pubmed: 1411571
Clin Exp Metastasis. 2018 Apr;35(4):309-318
pubmed: 29799080
Cell Death Differ. 2018 Mar;25(3):486-541
pubmed: 29362479
Biomed Pharmacother. 2015 Apr;71:161-71
pubmed: 25960232
J Cell Biochem. 2010 Dec 15;111(6):1426-36
pubmed: 20830746
Cell. 2010 Mar 19;140(6):883-99
pubmed: 20303878
Clin Pharmacol Ther. 2014 Apr;95(4):354-5
pubmed: 24646483
Trends Cell Biol. 2015 Jun;25(6):347-53
pubmed: 25662614
Infect Control Hosp Epidemiol. 2014 Oct;35(10):1209-28
pubmed: 25203174
Cancer Chemother Pharmacol. 2002 Nov;50(5):343-52
pubmed: 12439591
Cell Signal. 2014 May;26(5):917-24
pubmed: 24462646
J Pharmacol Sci. 2013;123(2):102-9
pubmed: 24048094
Leukemia. 2012 Jun;26(6):1293-300
pubmed: 22157808
Gynecol Oncol. 2007 Apr;105(1):23-30
pubmed: 17234261
Oncogene. 2012 Dec 6;31(49):5045-60
pubmed: 22310284
J Biomol Struct Dyn. 2020 Dec 11;:1-9
pubmed: 33306006
Science. 1986 Sep 5;233(4768):1061-8
pubmed: 3090687
Cancer Res. 2012 Jun 1;72(11):2791-801
pubmed: 22472122
Curr Med Chem Anticancer Agents. 2002 Jul;2(4):485-537
pubmed: 12678733
Immunity. 2013 Feb 21;38(2):209-23
pubmed: 23438821
Anticancer Drugs. 2013 Oct;24(9):920-7
pubmed: 23958790
Eur J Pharmacol. 2011 May 20;659(1):7-14
pubmed: 21262221
Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17450-5
pubmed: 24101526
Oncotarget. 2018 Nov 6;9(87):35762-35779
pubmed: 30515268
Dev Cell. 2019 Aug 5;50(3):381-392.e5
pubmed: 31257175
Bioorg Med Chem Lett. 2015 Jun 15;25(12):2559-64
pubmed: 25959811
J Clin Invest. 2014 Mar;124(3):1406-17
pubmed: 24569374
Cell Death Differ. 2009 Jan;16(1):3-11
pubmed: 18846107
Nutr Cancer. 2004;48(2):198-206
pubmed: 15231455
Biochem Pharmacol. 2012 Nov 15;84(10):1260-7
pubmed: 22842630
Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):13033-7
pubmed: 7809167
Biochem Pharmacol. 2010 Apr 15;79(8):1134-40
pubmed: 20005210
Anticancer Agents Med Chem. 2011 Mar;11(3):267-71
pubmed: 21269260
Biochem Biophys Res Commun. 2020 May 28;526(2):321-327
pubmed: 32220496
Autophagy. 2007 Sep-Oct;3(5):480-3
pubmed: 17507797
J Cell Biol. 2011 Feb 21;192(4):615-29
pubmed: 21339330
J Pharmacol Sci. 2015 May;128(1):27-34
pubmed: 26003085
Biol Pharm Bull. 2011;34(1):47-53
pubmed: 21212516
Semin Cancer Biol. 2018 Feb;48:36-52
pubmed: 28571764
Genes Dev. 2004 Jun 1;18(11):1272-82
pubmed: 15145826
Tumour Biol. 2016 Sep;37(9):12889-12896
pubmed: 27449042
Anticancer Agents Med Chem. 2017 Nov 24;17(11):1466-1476
pubmed: 29034843
Nat Rev Mol Cell Biol. 2010 Oct;11(10):700-14
pubmed: 20823910
Cell Res. 2014 Jan;24(1):58-68
pubmed: 24296784
Science. 2020 Jan 17;367(6475):301-305
pubmed: 31806695
Anticancer Agents Med Chem. 2014;14(7):936-45
pubmed: 24568161
Molecules. 2014 Aug 15;19(8):12349-67
pubmed: 25153862
Cell. 1995 May 19;81(4):495-504
pubmed: 7758105
Blood. 2012 May 31;119(22):5201-10
pubmed: 22496163
Clin Exp Pharmacol Physiol. 2016 Aug;43(8):723-37
pubmed: 27097837
Int J Mol Sci. 2012;13(6):7212-25
pubmed: 22837689
Science. 2020 Jan 17;367(6475):246-247
pubmed: 31949066
Annu Rev Physiol. 2014;76:129-50
pubmed: 24079414
Curr Genomics. 2017 Apr;18(2):132-155
pubmed: 28367073
Cell Death Dis. 2019 Feb 21;10(3):177
pubmed: 30792387
Nat Med. 2010 Dec;16(12):1434-8
pubmed: 21102458
PLoS One. 2020 Oct 14;15(10):e0240676
pubmed: 33052979
Int J Mol Med. 2011 Nov;28(5):689-96
pubmed: 21743956
Cell Death Dis. 2020 Nov 18;11(11):992
pubmed: 33208727
Curr Top Med Chem. 2015;15(8):720-44
pubmed: 25732790
Molecules. 2017 Sep 05;22(9):
pubmed: 28872603
Mol Cell. 2007 Jun 8;26(5):675-87
pubmed: 17560373
Yakugaku Zasshi. 2006 Dec;126(12):1383-6
pubmed: 17139164
J Exp Clin Cancer Res. 2017 Nov 7;36(1):157
pubmed: 29116019
Planta Med. 2010 Aug;76(11):1075-9
pubmed: 20486070
Anticancer Agents Med Chem. 2012 Oct 1;12(8):994-1000
pubmed: 22339063
Mol Cancer. 2019 May 23;18(1):100
pubmed: 31122251
Invest New Drugs. 2020 Feb;38(1):50-59
pubmed: 30924024
Alkaloids Chem Biol. 2007;64:1-47
pubmed: 18085328
J Clin Oncol. 2004 Jun 15;22(12):2489-503
pubmed: 15197212
Int J Mol Sci. 2018 Oct 15;19(10):
pubmed: 30326566
PLoS One. 2014 Jul 28;9(7):e102535
pubmed: 25068516
Toxicol In Vitro. 2015 Aug;29(5):1026-33
pubmed: 25882683
Cells. 2021 Feb 21;10(2):
pubmed: 33669953
Int J Cancer. 2015 Sep 15;137(6):1446-56
pubmed: 25688715
Int J Mol Sci. 2020 Dec 22;22(1):
pubmed: 33374919