Adipose-Derived Mesenchymal Stem Cells-Conditioned Medium Modulates the Expression of Inflammation Induced Bone Morphogenetic Protein-2, -5 and -6 as Well as Compared with Shockwave Therapy on Rat Knee Osteoarthritis.
adipose-derived mesenchymal stem cells
cartilage repair
conditioned medium
osteoarthritis
shockwave
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
05 Oct 2021
05 Oct 2021
Historique:
received:
20
08
2021
revised:
01
10
2021
accepted:
02
10
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
24
10
2021
Statut:
epublish
Résumé
The dose-dependent effects of adipose-derived mesenchymal stem cell-conditioned medium (ADSC-CM) were compared with those of shockwave (SW) therapy in the treatment of early osteoarthritis (OA). Anterior cruciate ligament transaction (ACLT) with medial meniscectomy (MMx) was performed in rats divided into sham, OA, SW, CM1 (intra-articular injection of 100 μL ADSC-CM into knee OA), and CM2 (intra-articular injection of 200 μL ADSC-CM) groups. Cartilage grading, grading of synovium changes, and specific molecular analysis by immunohistochemistry staining were performed. The OARSI and synovitis scores of CM2 and SW group were significantly decreased compared with those of the OA group (
Identifiants
pubmed: 34680516
pii: biomedicines9101399
doi: 10.3390/biomedicines9101399
pmc: PMC8533238
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Science and Technology, Taiwan
ID : MOST 108-2314-B-182A-075 and MOST 109-2314-B-182A-037
Organisme : Chang Gung Medical Foundation
ID : CMRPG8H0281 and CMRPG8H0282
Références
Int J Med Sci. 2017 Feb 23;14(3):213-223
pubmed: 28367081
Stem Cells Int. 2015;2015:597652
pubmed: 26240572
Osteoarthritis Cartilage. 2006 Jan;14(1):13-29
pubmed: 16242352
PM R. 2011 Jun;3(6 Suppl 1):S3-11
pubmed: 21703577
Int J Mol Sci. 2020 Feb 12;21(4):
pubmed: 32059379
J Cell Physiol. 2008 Apr;215(1):68-76
pubmed: 17960567
Mediators Inflamm. 2013;2013:357014
pubmed: 24363499
J Clin Invest. 1994 Dec;94(6):2307-16
pubmed: 7989586
PLoS One. 2008 Apr 02;3(4):e1886
pubmed: 18382669
Proc Assoc Am Physicians. 1998 Jan-Feb;110(1):65-72
pubmed: 9460084
Arthritis Rheum. 2012 Jun;64(6):1697-707
pubmed: 22392533
Nat Rev Rheumatol. 2011 Jan;7(1):33-42
pubmed: 21119608
Stem Cell Res Ther. 2021 Jan 4;12(1):1
pubmed: 33397467
J Biomed Mater Res A. 2014 Jul;102(7):2448-66
pubmed: 23894033
Stem Cell Res Ther. 2020 Dec 3;11(1):521
pubmed: 33272318
Biomed Res Int. 2013;2013:383685
pubmed: 24106704
Osteoarthritis Cartilage. 2008;16 Suppl 2:S15-20
pubmed: 18794013
Mol Med Rep. 2020 May;21(5):2243-2250
pubmed: 32323772
Front Cell Dev Biol. 2019 Dec 10;7:323
pubmed: 31921840
Cell Physiol Biochem. 2018;47(1):11-25
pubmed: 29763932
PLoS One. 2014 Sep 08;9(9):e107001
pubmed: 25198551
Res Vet Sci. 2020 Oct;132:513-520
pubmed: 32805699
Circ Res. 2007 May 11;100(9):1249-60
pubmed: 17495232
World J Stem Cells. 2017 Aug 26;9(8):107-117
pubmed: 28928907
Stem Cells. 2006 Feb;24(2):376-85
pubmed: 16322640
Osteoarthritis Cartilage. 2003 Apr;11(4):278-84
pubmed: 12681954
Cell Transplant. 2014;23(9):1045-59
pubmed: 23676629
Sci Rep. 2017 Feb 21;7:42793
pubmed: 28220818
Int J Mol Sci. 2020 Aug 21;21(17):
pubmed: 32825633
ScientificWorldJournal. 2012;2012:467892
pubmed: 22272175
Stem Cell Res Ther. 2020 Jul 22;11(1):312
pubmed: 32698868
Curr Rev Musculoskelet Med. 2020 Jun;13(3):264-280
pubmed: 32328959
Osteoarthritis Cartilage. 2018 Mar;26(3):319-325
pubmed: 29229563
Pharmaceuticals (Basel). 2021 Apr 01;14(4):
pubmed: 33916108
BMC Musculoskelet Disord. 2013 Jan 28;14:44
pubmed: 23356403
Open Rheumatol J. 2011;5:100-6
pubmed: 22279508
Osteoarthritis Cartilage. 2010 Jun;18(6):735-41
pubmed: 20211748
Arthritis Rheum. 2003 Sep;48(9):2501-8
pubmed: 13130469
Transplantation. 2013 Jun 27;95(12):1535-41
pubmed: 23680930
Ann Rheum Dis. 2016 Feb;75(2):390-5
pubmed: 25488799
J Vis Exp. 2010 Mar 22;(37):
pubmed: 20308982
Curr Opin Rheumatol. 2013 Jan;25(1):119-26
pubmed: 23190869
J Mol Endocrinol. 2018 Jul 23;61(4):173-184
pubmed: 30038054
Biorheology. 2002;39(1-2):237-46
pubmed: 12082286
Stem Cells. 2005 Mar;23(3):412-23
pubmed: 15749936
J Surg Res. 2012 Nov;178(1):196-205
pubmed: 22608545
Nucleic Acids Res. 2001 Nov 1;29(21):4361-72
pubmed: 11691923
Int J Mol Sci. 2018 Sep 30;19(10):
pubmed: 30274394
Front Cell Dev Biol. 2020 Dec 10;8:593386
pubmed: 33363147
Int J Mol Sci. 2017 Aug 25;18(9):
pubmed: 28841158
Rheum Dis Clin North Am. 1999 May;25(2):269-82
pubmed: 10356417