Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a High-Fat Diet.

NAFLD combined metabolic activators mitochondrial metabolism transcriptomics

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
11 Oct 2021
Historique:
received: 27 07 2021
revised: 04 10 2021
accepted: 06 10 2021
entrez: 23 10 2021
pubmed: 24 10 2021
medline: 24 10 2021
Statut: epublish

Résumé

Although the prevalence of non-alcoholic fatty liver disease (NAFLD) continues to increase, there is no effective treatment approved for this condition. We previously showed, in high-fat diet (HFD)-fed mice, that the supplementation of combined metabolic activators (CMA), including nicotinamide riboside (NAD

Identifiants

pubmed: 34680557
pii: biomedicines9101440
doi: 10.3390/biomedicines9101440
pmc: PMC8533474
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Agència per a la Competitivitat de l'Empresa
ID : TECCT11-1-0012
Organisme : Centro para el Desarrollo Tecnológico Industrial
ID : TECNOMIFOOD project
Organisme : Knut och Alice Wallenbergs Stiftelse
ID : 72110

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Auteurs

Hong Yang (H)

Science for Life Laboratory, KTH Royal Institute of Technology, SE-17165 Stockholm, Sweden.

Jordi Mayneris-Perxachs (J)

Department of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Doctor Josep Trueta, 17190 Girona, Spain.
Center for Pathophysiology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.

Noemí Boqué (N)

Eurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, Spain.

Josep M Del Bas (JM)

Eurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, Spain.

Lluís Arola (L)

Eurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, Spain.
Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Campus Sescelades, Universitat Rovira i Virgili, 43007 Tarragona, Spain.

Meng Yuan (M)

Science for Life Laboratory, KTH Royal Institute of Technology, SE-17165 Stockholm, Sweden.

Hasan Türkez (H)

Department of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum 25030, Turkey.

Mathias Uhlén (M)

Science for Life Laboratory, KTH Royal Institute of Technology, SE-17165 Stockholm, Sweden.

Jan Borén (J)

Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, SE-40233 Gothenburg, Sweden.

Cheng Zhang (C)

Science for Life Laboratory, KTH Royal Institute of Technology, SE-17165 Stockholm, Sweden.
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.

Adil Mardinoglu (A)

Science for Life Laboratory, KTH Royal Institute of Technology, SE-17165 Stockholm, Sweden.
Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London WC2R 2LS, UK.

Antoni Caimari (A)

Eurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, Spain.

Classifications MeSH