The Association between Use of ICS and Psychiatric Symptoms in Patients with COPD-A Nationwide Cohort Study of 49,500 Patients.
COPD
ICS
anxiety
bipolar disorder
depression
obstructive lung disease
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
18 Oct 2021
18 Oct 2021
Historique:
received:
16
09
2021
revised:
09
10
2021
accepted:
13
10
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
24
10
2021
Statut:
epublish
Résumé
Psychiatric side effects are well known from treatment with systemic corticosteroids. It is, however, unclear whether inhaled corticosteroids (ICS) have psychiatric side effects in patients with COPD. We conducted a nationwide cohort study in all Danish COPD outpatients who had respiratory medicine specialist-verified COPD, age ≥40 years, and no previous cancer. Prescription fillings of antidepressants and risk of admissions to psychiatric hospitals with either depression, anxiety or bipolar disorder were assessed by Cox proportional hazards models. We observed a dose-dependent increase in the risk of antidepressant-use with ICS cumulated dose (HR 1.05, 95% CI 1.03-1.07,
Identifiants
pubmed: 34680609
pii: biomedicines9101492
doi: 10.3390/biomedicines9101492
pmc: PMC8533368
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Novo Nordisk Foundation
ID : NNF20OC0060657
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