Non-Recombinogenic Functions of Rad51, BRCA2, and Rad52 in DNA Damage Tolerance.
BRCA2
DNA damage tolerance
Rad51
Rad52
homologous recombination
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
29 09 2021
29 09 2021
Historique:
received:
07
09
2021
revised:
20
09
2021
accepted:
23
09
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
9
2
2022
Statut:
epublish
Résumé
The DNA damage tolerance (DDT) response is aimed to timely and safely complete DNA replication by facilitating the advance of replication forks through blocking lesions. This process is associated with an accumulation of single-strand DNA (ssDNA), both at the fork and behind the fork. Lesion bypass and ssDNA filling can be performed by translation synthesis (TLS) and template switching mechanisms. TLS uses low-fidelity polymerases to incorporate a dNTP opposite the blocking lesion, whereas template switching uses a Rad51/ssDNA nucleofilament and the sister chromatid to bypass the lesion. Rad51 is loaded at this nucleofilament by two mediator proteins, BRCA2 and Rad52, and these three factors are critical for homologous recombination (HR). Here, we review recent advances showing that Rad51, BRCA2, and Rad52 perform some of these functions through mechanisms that do not require the strand exchange activity of Rad51: the formation and protection of reversed fork structures aimed to bypass blocking lesions, and the promotion of TLS. These findings point to the central HR proteins as potential molecular switches in the choice of the mechanism of DDT.
Identifiants
pubmed: 34680945
pii: genes12101550
doi: 10.3390/genes12101550
pmc: PMC8535942
pii:
doi:
Substances chimiques
BRCA1 Protein
0
Rad52 DNA Repair and Recombination Protein
0
Rad51 Recombinase
EC 2.7.7.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Genes Dev. 1999 Aug 15;13(16):2159-76
pubmed: 10465792
Nature. 2008 Dec 18;456(7224):915-20
pubmed: 19092928
Mol Microbiol. 2009 Jul;73(1):89-102
pubmed: 19496932
Nat Rev Mol Cell Biol. 2015 Apr;16(4):207-20
pubmed: 25714681
Cell Rep. 2014 Oct 23;9(2):460-8
pubmed: 25310987
Nat Commun. 2017 Oct 16;8(1):859
pubmed: 29038466
Mol Cell. 2015 Aug 6;59(3):478-90
pubmed: 26253028
Genes (Basel). 2018 Dec 04;9(12):
pubmed: 30518053
Front Cell Dev Biol. 2021 May 10;9:670392
pubmed: 34041245
Cell Rep. 2013 Jun 27;3(6):1958-69
pubmed: 23746452
Mol Cell. 2012 Aug 10;47(3):396-409
pubmed: 22704558
Nature. 2016 Jul 20;535(7612):382-7
pubmed: 27443740
Nature. 2002 Nov 21;420(6913):287-93
pubmed: 12442171
Mol Cell. 2020 Jan 2;77(1):3-16.e4
pubmed: 31607544
Front Genet. 2013 Mar 13;4:26
pubmed: 23493417
EMBO J. 2009 Apr 22;28(8):1131-41
pubmed: 19322196
Nucleic Acids Res. 2011 Mar;39(6):2153-64
pubmed: 21097884
Mol Cell. 2008 Mar 14;29(5):625-36
pubmed: 18342608
EMBO J. 2013 May 2;32(9):1307-21
pubmed: 23563117
Genes Dev. 2000 Jan 1;14(1):81-96
pubmed: 10640278
Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10729-34
pubmed: 8855248
EMBO J. 2009 Sep 2;28(17):2601-15
pubmed: 19629035
Nature. 2005 Feb 10;433(7026):653-7
pubmed: 15703751
Nat Commun. 2019 Sep 27;10(1):4410
pubmed: 31562309
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):8971-6
pubmed: 16751278
Nat Commun. 2017 Jul 17;8:15983
pubmed: 28714477
Cell Rep. 2018 Jul 17;24(3):538-545
pubmed: 30021152
Nature. 2005 Jul 21;436(7049):428-33
pubmed: 15931174
Genes Cells. 2008 Apr;13(4):343-54
pubmed: 18363965
Biochem Biophys Res Commun. 2005 Apr 22;329(4):1240-5
pubmed: 15766559
Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):686-91
pubmed: 21148102
Nat Struct Mol Biol. 2017 Jan;24(1):40-46
pubmed: 27941862
Mol Cell. 2021 Jul 15;81(14):3007-3017.e5
pubmed: 34107305
Nat Struct Mol Biol. 2007 Jun;14(6):468-74
pubmed: 17515904
Nat Struct Mol Biol. 2012 Mar 04;19(4):417-23
pubmed: 22388737
Mol Biol Cell. 2007 Oct;18(10):4062-73
pubmed: 17671161
Nature. 2013 Oct 17;502(7471):393-6
pubmed: 24025768
Genes Cells. 2013 Jan;18(1):17-31
pubmed: 23134523
Cell Cycle. 2015;14(3):333-41
pubmed: 25659032
Genes (Basel). 2017 Jan 10;8(1):
pubmed: 28075396
Cell Rep. 2021 Jul 27;36(4):109440
pubmed: 34320356
Nucleic Acids Res. 2021 Jul 9;49(12):6832-6848
pubmed: 34157114
Cold Spring Harb Perspect Biol. 2015 Apr 01;7(4):a016600
pubmed: 25833843
Nucleic Acids Res. 2012 Dec;40(22):11380-8
pubmed: 23034805
Nat Commun. 2020 Jul 15;11(1):3531
pubmed: 32669601
Cell. 1995 Aug 11;82(3):453-61
pubmed: 7634335
J Biol Chem. 1997 Sep 12;272(37):23360-5
pubmed: 9287349
Mol Cell. 2006 Jan 6;21(1):15-27
pubmed: 16387650
Mol Cell Biol. 2010 Feb;30(3):684-93
pubmed: 19948885
Nat Struct Mol Biol. 2010 Nov;17(11):1305-11
pubmed: 20935632
Genes Dev. 2005 Feb 1;19(3):339-50
pubmed: 15687257
Nat Commun. 2017 Sep 13;8(1):525
pubmed: 28904335
Nature. 2002 Sep 12;419(6903):135-41
pubmed: 12226657
Genes (Basel). 2017 Jan 24;8(2):
pubmed: 28125036
Nat Rev Mol Cell Biol. 2020 Oct;21(10):633-651
pubmed: 32612242
Mol Cell. 2020 Jun 18;78(6):1237-1251.e7
pubmed: 32442397
Mol Cell Biol. 2006 Feb;26(4):1424-33
pubmed: 16449653
J Biol Chem. 1999 Nov 26;274(48):33839-42
pubmed: 10567339
Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):441-2
pubmed: 21189297
Genetics. 1990 Apr;124(4):817-31
pubmed: 2182387
Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):763-8
pubmed: 24347643
Science. 2015 Aug 28;349(6251):977-81
pubmed: 26315438
Mol Cell. 2021 Feb 18;81(4):649-658
pubmed: 33515486
Mol Cell. 2010 Sep 24;39(6):862-72
pubmed: 20864034
Science. 2002 Jul 26;297(5581):599-602
pubmed: 12142537
Cell. 2015 Feb 26;160(5):856-869
pubmed: 25684365
Mol Cell. 2017 Sep 7;67(5):867-881.e7
pubmed: 28757209
Mol Cell. 2017 Sep 7;67(5):882-890.e5
pubmed: 28886337
Science. 2012 Sep 7;337(6099):1222-5
pubmed: 22955832
Mutat Res. 1991 Aug;263(4):211-5
pubmed: 1861685
Oncogene. 2016 Jan 7;35(1):22-34
pubmed: 25893307
EMBO Rep. 2021 Jan 7;22(1):e50410
pubmed: 33289333
Genes Dev. 1994 Apr 1;8(7):811-20
pubmed: 7926769
Mol Cell. 2017 Aug 3;67(3):374-386.e5
pubmed: 28735897
Cell. 1997 Jul 11;90(1):87-96
pubmed: 9230305
Mol Cell. 2015 Mar 5;57(5):812-823
pubmed: 25661486
Annu Rev Genet. 2010;44:113-39
pubmed: 20690856
Nat Struct Mol Biol. 2014 Oct;21(10):884-92
pubmed: 25195051
Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7131-6
pubmed: 8692957
Mol Cell Oncol. 2014 Oct 29;1(2):e957039
pubmed: 27308329
Annu Rev Cancer Biol. 2018 Mar;2:313-336
pubmed: 30345412
Cancer Cell. 2012 Jul 10;22(1):106-16
pubmed: 22789542
EMBO J. 2018 May 2;37(9):
pubmed: 29581097
Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5410-5
pubmed: 23509251
EMBO J. 1994 Dec 1;13(23):5764-71
pubmed: 7988572
Nat Struct Mol Biol. 2015 Nov;22(11):932-8
pubmed: 26436826
Genetics. 2005 Mar;169(3):1275-89
pubmed: 15654096
Genetics. 1995 Jan;139(1):109-23
pubmed: 7705617
Mol Cell. 2017 May 4;66(3):398-410.e4
pubmed: 28475874
Mol Cell Biol. 2008 Mar;28(5):1724-38
pubmed: 18180284
Cell. 2011 May 13;145(4):529-42
pubmed: 21565612
Nucleic Acids Res. 2015 Nov 16;43(20):9835-55
pubmed: 26354865
EMBO Rep. 2009 Jul;10(7):790-6
pubmed: 19465889
Genetics. 1998 Sep;150(1):75-93
pubmed: 9725831
EMBO Rep. 2017 Nov;18(11):1991-2003
pubmed: 29021206
Science. 2003 May 23;300(5623):1300-3
pubmed: 12764199
Curr Biol. 2009 Aug 25;19(16):R676-7
pubmed: 19706272
Crit Rev Biochem Mol Biol. 2016 May-Jun;51(3):195-212
pubmed: 27098756
Nat Commun. 2021 Sep 10;12(1):5380
pubmed: 34508092
PLoS Genet. 2010 Nov 11;6(11):e1001205
pubmed: 21085632
Mol Cell. 2002 Nov;10(5):1175-88
pubmed: 12453424
Nature. 2015 Dec 10;528(7581):286-90
pubmed: 26633632
Nucleic Acids Res. 2018 Sep 19;46(16):8347-8356
pubmed: 30107417
J Cell Biol. 2015 Mar 2;208(5):563-79
pubmed: 25733714
Nat Struct Mol Biol. 2018 Jun;25(6):446-453
pubmed: 29807999
DNA Repair (Amst). 2008 Oct 1;7(10):1693-704
pubmed: 18640290
Cell. 2009 Mar 20;136(6):1032-43
pubmed: 19303847
Science. 2005 Dec 16;310(5755):1821-4
pubmed: 16357261
Mol Cell. 2016 Dec 15;64(6):1117-1126
pubmed: 27984745
Mol Cell. 2021 Mar 4;81(5):1074-1083.e5
pubmed: 33453169
Nat Struct Mol Biol. 2013 Dec;20(12):1383-9
pubmed: 24240614
Mol Cell. 2013 Nov 21;52(4):541-53
pubmed: 24207056
Curr Genet. 2003 Jan;42(4):185-98
pubmed: 12589470
Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16125-30
pubmed: 18845679
Nature. 2013 Oct 17;502(7471):389-92
pubmed: 24025772