MAP/Microtubule Affinity Regulating Kinase 4 Inhibitory Potential of Irisin: A New Therapeutic Strategy to Combat Cancer and Alzheimer's Disease.
Alzheimer Disease
/ drug therapy
Binding Sites
Fibronectins
/ chemistry
Humans
Hydrogen Bonding
Kinetics
Molecular Docking Simulation
Molecular Dynamics Simulation
Neoplasms
/ drug therapy
Protein Binding
Protein Kinase Inhibitors
/ chemistry
Protein Serine-Threonine Kinases
/ antagonists & inhibitors
Protein Stability
cancer therapy
kinase inhibitors
microtubule dynamics
molecular dynamics simulation
neurodegenerative diseases
protein-protein interaction
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Oct 2021
12 Oct 2021
Historique:
received:
17
08
2021
revised:
21
09
2021
accepted:
25
09
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
28
12
2021
Statut:
epublish
Résumé
Irisin is a clinically significant protein playing a valuable role in regulating various diseases. Irisin attenuates synaptic and memory dysfunction, highlighting its importance in Alzheimer's disease. On the other hand, Microtubule Affinity Regulating Kinase 4 (MARK4) is associated with various cancer types, uncontrolled neuronal migrations, and disrupted microtubule dynamics. In addition, MARK4 has been explored as a potential drug target for cancer and Alzheimer's disease therapy. Here, we studied the binding and subsequent inhibition of MARK4 by irisin. Irisin binds to MARK4 with an admirable affinity (
Identifiants
pubmed: 34681645
pii: ijms222010986
doi: 10.3390/ijms222010986
pmc: PMC8537121
pii:
doi:
Substances chimiques
FNDC5 protein, human
0
Fibronectins
0
Protein Kinase Inhibitors
0
MARK4 protein, human
EC 2.7.1.-
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Taif University
ID : TURSP-2020/131
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