m
Adenosine
/ analogs & derivatives
Cell Line
Cell Survival
/ drug effects
Cytoplasm
/ metabolism
Genetic Loci
Humans
Liquid-Liquid Extraction
Mutagenesis, Site-Directed
Protein Aggregates
/ drug effects
Protein Binding
RNA
/ chemistry
RNA, Long Noncoding
/ chemistry
RNA-Binding Protein FUS
/ chemistry
Sorbitol
/ pharmacology
LLPS
RNA m6A modification
TLS/FUS
lncRNA
pncRNA-D
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Oct 2021
12 Oct 2021
Historique:
received:
30
08
2021
revised:
08
10
2021
accepted:
08
10
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
28
12
2021
Statut:
epublish
Résumé
Translocated in LipoSarcoma/Fused in Sarcoma (TLS/FUS) is a nuclear RNA binding protein whose mutations cause amyotrophic lateral sclerosis. TLS/FUS undergoes LLPS and forms membraneless particles with other proteins and nucleic acids. Interaction with RNA alters conformation of TLS/FUS, which affects binding with proteins, but the effect of m
Identifiants
pubmed: 34681673
pii: ijms222011014
doi: 10.3390/ijms222011014
pmc: PMC8539258
pii:
doi:
Substances chimiques
Protein Aggregates
0
RNA, Long Noncoding
0
RNA-Binding Protein FUS
0
Sorbitol
506T60A25R
RNA
63231-63-0
N-methyladenosine
CLE6G00625
Adenosine
K72T3FS567
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 18K06939 (to R.K.)
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 17K18065 and 20K16452 (to R.Y.)
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