The Interplay between Anticholinergic Burden and Anemia in Relation to 1-Year Mortality among Older Patients Discharged from Acute Care Hospitals.
anemia
anticholinergic burden
hospital
older patients
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
11 Oct 2021
11 Oct 2021
Historique:
received:
30
07
2021
revised:
26
09
2021
accepted:
08
10
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
24
10
2021
Statut:
epublish
Résumé
Anticholinergic burden (ACB) and anemia were found associated with an increased risk of death among older patients. Additionally, anticholinergic medications may contribute to the development of anemia. Therefore, we aimed at investigating the prognostic interplay of ACB and anemia among older patients discharged from hospital. Our series consisted of 783 patients enrolled in a multicenter observational study. The outcome of the study was 1 year mortality. ACB was assessed by an Anticholinergic Cognitive Burden score. Anemia was defined as hemoglobin < 13 g/dL in men and <12 g/dL in women. The association between study variables and mortality was investigated by Cox regression analysis. After adjusting for several potential confounders, ACB score = 2 or more was significantly associated with the outcome in anemic patients (HR = 1.93, 95%CI = 1.13-3.40), but not non anemic patients (HR = 1.51, 95%CI = 0.65-3.48). An additive prognostic interaction between ACB and anemia was observed (
Identifiants
pubmed: 34682773
pii: jcm10204650
doi: 10.3390/jcm10204650
pmc: PMC8539729
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministero della Salute
ID : GR-2007 685638
Organisme : IRCCS INRCA
ID : Intramural funding
Références
Clin Hemorheol Microcirc. 2001;25(3-4):153-63
pubmed: 11847418
J Gerontol A Biol Sci Med Sci. 2006 May;61(5):474-9
pubmed: 16720744
Brain Sci. 2021 Jun 11;11(6):
pubmed: 34208355
Intern Emerg Med. 2015 Aug;10(5):581-6
pubmed: 25633233
Am J Geriatr Pharmacother. 2006 Mar;4(1):42-51
pubmed: 16730620
Am J Geriatr Psychiatry. 2013 Aug;21(8):785-93
pubmed: 23567395
J Am Geriatr Soc. 2004 May;52(5):719-24
pubmed: 15086651
Indian J Clin Biochem. 2018 Oct;33(4):445-449
pubmed: 30319191
Calcif Tissue Int. 2020 Aug;107(2):135-142
pubmed: 32440760
Oncotarget. 2017 Jun 16;8(34):57003-57011
pubmed: 28915649
Haematologica. 2009 Jan;94(1):1-2
pubmed: 19118372
Chem Biol Interact. 2019 Aug 1;308:317-322
pubmed: 31170385
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
J Membr Biol. 2010 Apr;234(3):227-34
pubmed: 20352203
BMC Geriatr. 2015 Mar 25;15:31
pubmed: 25879993
Drugs Aging. 2018 Oct;35(10):917-924
pubmed: 30191516
Sci Rep. 2018 Aug 3;8(1):11688
pubmed: 30076332
JAMA. 1963 Sep 21;185:914-9
pubmed: 14044222
Expert Opin Drug Saf. 2016 Jun;15(6):753-68
pubmed: 26966981
PLoS One. 2008 Apr 02;3(4):e1920
pubmed: 18382689
J Clin Psychol. 1994 Mar;50(2):256-60
pubmed: 8014251
Curr Drug Saf. 2013 Apr;8(2):98-103
pubmed: 23713540
BMC Geriatr. 2008 Jan 14;8:1
pubmed: 18194534
Eur J Epidemiol. 1994 Aug;10(4):405-11
pubmed: 7843344
J Am Med Dir Assoc. 2018 Nov;19(11):942-947
pubmed: 30049542
Geriatr Gerontol Int. 2016 Apr;16(4):424-31
pubmed: 25952295
Science. 1981 Aug 7;213(4508):674-6
pubmed: 7256270
Maturitas. 2016 Feb;84:32-7
pubmed: 26531071
Curr Med Chem. 2010;17(6):571-84
pubmed: 20015034
Curr Psychiatry Rep. 2010 Feb;12(1):28-33
pubmed: 20425307
Aging Clin Exp Res. 2016 Feb;28(1):25-35
pubmed: 25930085
Eur J Intern Med. 2019 Mar;61:69-74
pubmed: 30449478
Int J Geriatr Psychiatry. 2006 Jun;21(6):529-34
pubmed: 16783797
Age Ageing. 2015 Mar;44(2):219-25
pubmed: 25430550
J R Soc Med. 2000 Sep;93(9):457-62
pubmed: 11089480
Sci Transl Med. 2019 Sep 25;11(511):
pubmed: 31554738
Exp Gerontol. 2021 Jul 15;150:111379
pubmed: 33930506
Rejuvenation Res. 2016 Dec;19(6):447-455
pubmed: 26778182
Circ Heart Fail. 2014 May;7(3):401-8
pubmed: 24737459
Am J Dig Dis. 1971 Sep;16(9):789-95
pubmed: 5098207
Res Social Adm Pharm. 2020 Mar;16(3):329-335
pubmed: 31182419
J Gerontol A Biol Sci Med Sci. 2020 Jan 20;75(2):357-365
pubmed: 30668633
Neurotox Res. 2021 Aug;39(4):1087-1102
pubmed: 33721210
J Card Fail. 2006 Sep;12(7):533-9
pubmed: 16952787
J Am Med Dir Assoc. 2016 Nov 1;17(11):1056-1059
pubmed: 27590402
Intern Emerg Med. 2017 Sep;12(6):749-756
pubmed: 28233161
Drugs Aging. 2020 Jun;37(6):447-455
pubmed: 32415534
Molecules. 2017 Sep 08;22(9):
pubmed: 28885588
Eur Geriatr Med. 2021 Jun;12(3):431-434
pubmed: 33834424
Geriatr Gerontol Int. 2018 May;18(5):705-713
pubmed: 29292589
J Clin Med. 2020 Mar 30;9(4):
pubmed: 32235484
J Neuroimmunol. 2008 Feb;194(1-2):83-8
pubmed: 18190972
Crit Care Med. 1990 Feb;18(2):213-7
pubmed: 2298015
J Am Geriatr Soc. 2011 Aug;59(8):1477-83
pubmed: 21707557
Eur J Clin Pharmacol. 2005 Jul;61(5-6):453-9
pubmed: 15912391