Real-Life Impact of Glucocorticoid Treatment in COVID-19 Mortality: A Multicenter Retrospective Study.

COVID-19 SARS-CoV-2 corticosteroids mortality

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
13 Oct 2021
Historique:
received: 02 09 2021
revised: 06 10 2021
accepted: 08 10 2021
entrez: 23 10 2021
pubmed: 24 10 2021
medline: 24 10 2021
Statut: epublish

Résumé

We aimed to determine the impact of steroid use in COVID-19 in-hospital mortality, in a retrospective cohort study of the SEMICOVID19 database of admitted patients with SARS-CoV-2 laboratory-confirmed pneumonia from 131 Spanish hospitals. Patients treated with corticosteroids were compared to patients not treated with corticosteroids; and adjusted using a propensity-score for steroid treatment. From March-July 2020, 5.262 (35.26%) were treated with corticosteroids and 9.659 (64.73%) were not. In-hospital mortality overall was 20.50%; it was higher in patients treated with corticosteroids than in controls (28.5% versus 16.2%, OR 2.068 [95% confidence interval; 1.908 to 2.242];

Identifiants

pubmed: 34682801
pii: jcm10204678
doi: 10.3390/jcm10204678
pmc: PMC8540860
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Ana Muñoz-Gómez (A)

Internal Medicine Department, Hospital de Parla, 28981 Madrid, Spain.

Ana Fernández-Cruz (A)

Infectious Diseases Unit, Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, 28222 Madrid, Spain.

Cristina Lavilla-Olleros (C)

Internal Medicine Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.

Vicente Giner-Galvañ (V)

Internal Medicine Department, Hospital Clínico Universitario de Sant Joan d'Alacant, Fundación para el Fomento de la Investigación Sanitaria y Biomédica en la Comunidad Valenciana (FISABIO), 03550 Alicante, Spain.

Cristina Ausín-García (C)

Internal Medicine Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.

Philip Wikman (P)

Internal Medicine Department, Hospital Clínico Universitario de Sant Joan d'Alacant, Fundación para el Fomento de la Investigación Sanitaria y Biomédica en la Comunidad Valenciana (FISABIO), 03550 Alicante, Spain.

Alejandro D Bendala-Estrada (AD)

Internal Medicine Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.

Juan A Vargas (JA)

Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, 28222 Madrid, Spain.

Manuel Rubio-Rivas (M)

Department of Internal Medicine, Bellvitge University Hospital, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.

Jaime Laureiro (J)

Doce de Octubre University Hospital, 28041 Madrid, Spain.

Daniel Fernández-Bermúdez (D)

Internal Medicine Department, Costa del Sol Hospital, 29603 Marbella, Spain.

Verónica A Buonaiuto (VA)

Internal Medicine Department, Regional University Hospital of Málaga, Biomedical Research Institute of Málaga (IBIMA), University of Málaga (UMA), 29010 Málaga, Spain.

Antonio P Arenas de Larriva (AP)

Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Av. Menendez Pidal s/n, 14004 Córdoba, Spain.
CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28222 Madrid, Spain.

María de Los Reyes Pascual-Pérez (MLR)

Internal Medicine Department, University General Hospital of Elda, 03600 Alicante, Spain.

José N Alcalá-Pedrajas (JN)

Internal Medicine Department, Pozoblanco Regional Hospital, 14400 Córdoba, Spain.

Ane Labirua-Iturburu Ruiz (A)

Santa Marina Hospital, 48004 Bilbao, Spain.

Almudena Hernández-Milián (A)

Internal Medicine Department, Son Llàtzer University Hospital, 07198 Palma de Mallorca, Spain.

Marta Gómez Del Mazo (M)

Internal Medicine Department, San Pedro Hospital, 26006 Logroño, Spain.

Beatriz Antequera (B)

Internal Medicine Department, Sagunto Hospital, 46520 Valencia, Spain.

Carmen Mella-Pérez (C)

Universitary Hospital Complex of Ferrol, 15405 A Coruña, Spain.

María de la Sierra Navas-Alcántara (MS)

Internal Medicine Department, Infanta Margarita Hospital, Cabra, 14940 Córdoba, Spain.

Juan F Soto-Delgado (JF)

Internal Medicine Department, University Hospital of Salamanca, 37007 Salamanca, Spain.

Rosa M Gámez-Mancera (RM)

Internal Medicine Department, University Hospital Virgen del Rocío, 41013 Sevilla, Spain.

Cristina Sardiña-González (C)

Internal Medicine Department, Monforte de Lemos Public Hospital, 27400 Lugo, Spain.

Héctor Meijide-Míguez (H)

Internal Medicine Department, Quironsalud Hospital, 15009 A Coruña, Spain.

José M Ramos-Rincón (JM)

Department of Clinical Medicine, Miguel Hernandez University of Elche, 03203 Alicante, Spain.

Ricardo Gómez-Huelgas (R)

Internal Medicine Department, Regional University Hospital of Málaga, Biomedical Research Institute of Málaga (IBIMA), University of Málaga (UMA), 29010 Málaga, Spain.

Classifications MeSH