Are the Organoid Models an Invaluable Contribution to ZIKA Virus Research?
3D cell model
Zika virus
cellular microbiology
in vitro models
organoids
organotypic
tissue engineering models
viral research
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
24 Sep 2021
24 Sep 2021
Historique:
received:
31
08
2021
revised:
15
09
2021
accepted:
20
09
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
24
10
2021
Statut:
epublish
Résumé
In order to prevent new pathogen outbreaks and avoid possible new global health threats, it is important to study the mechanisms of microbial pathogenesis, screen new antiviral agents and test new vaccines using the best methods. In the last decade, organoids have provided a groundbreaking opportunity for modeling pathogen infections in human brains, including Zika virus (ZIKV) infection. ZIKV is a member of the Flavivirus genus, and it is recognized as an emerging infectious agent and a serious threat to global health. Organoids are 3D complex cellular models that offer an in-scale organ that is physiologically alike to the original one, useful for exploring the mechanisms behind pathogens infection; additionally, organoids integrate data generated in vitro with traditional tools and often support those obtained in vivo with animal model. In this mini-review the value of organoids for ZIKV research is examined and sustained by the most recent literature. Within a 3D viewpoint, tissue engineered models are proposed as future biological systems to help in deciphering pathogenic processes and evaluate preventive and therapeutic strategies against ZIKV. The next steps in this field constitute a challenge that may protect people and future generations from severe brain defects.
Identifiants
pubmed: 34684182
pii: pathogens10101233
doi: 10.3390/pathogens10101233
pmc: PMC8537471
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Nat Commun. 2017 Mar 16;8:14722
pubmed: 28300075
Nat Immunol. 2017 Nov;18(11):1261-1269
pubmed: 28945244
Lancet Infect Dis. 2016 Jul;16(7):e119-e126
pubmed: 27282424
Nat Rev Neurol. 2016 Jul;12(7):369
pubmed: 27231186
Antiviral Res. 2017 Jun;142:148-157
pubmed: 28343845
Cell Death Differ. 2021 Jan;28(1):35-51
pubmed: 32494027
Front Immunol. 2019 Jul 11;10:1617
pubmed: 31354746
Cell Stem Cell. 2016 Dec 1;19(6):703-708
pubmed: 27912091
Viruses. 2020 Nov 23;12(11):
pubmed: 33238561
Vaccines (Basel). 2021 Mar 22;9(3):
pubmed: 33810028
BMC Immunol. 2021 Jan 9;22(1):5
pubmed: 33421988
Science. 2016 May 13;352(6287):816-8
pubmed: 27064148
Lab Chip. 2021 Feb 9;21(3):473-488
pubmed: 33480945
PLoS Pathog. 2017 May 25;13(5):e1006378
pubmed: 28542585
Front Mol Biosci. 2021 Jun 24;8:686410
pubmed: 34250020
PLoS One. 2021 Jun 2;16(6):e0252198
pubmed: 34077451
Dev Biol. 2016 Dec 15;420(2):199-209
pubmed: 27402594
Nat Mater. 2021 Feb;20(2):145-155
pubmed: 33199860
Nature. 2016 Aug 4;536(7614):48-53
pubmed: 27338953
Cell Stem Cell. 2017 Aug 3;21(2):274-283.e5
pubmed: 28736217
iScience. 2021 Jan 19;24(2):102063
pubmed: 33554067
Cell Stem Cell. 2017 Sep 7;21(3):349-358.e6
pubmed: 28826723
Nat Rev Mol Cell Biol. 2020 Jul;21(7):355-356
pubmed: 32483314
Nature. 2016 Dec 15;540(7633):438-442
pubmed: 27798603
Front Cell Neurosci. 2020 Oct 21;14:602946
pubmed: 33192333
Viruses. 2019 Jan 06;11(1):
pubmed: 30621317
mSphere. 2021 Jun 30;:e0019221
pubmed: 34190582
Nat Commun. 2021 Apr 29;12(1):2469
pubmed: 33927207
Cells Tissues Organs. 2021 Mar 10;:1-10
pubmed: 33691312
Cell Host Microbe. 2007 Apr 19;1(2):135-45
pubmed: 18005691
Nature. 2018 Jan 24;553(7689):437-445
pubmed: 29364288
Viruses. 2019 Sep 19;11(9):
pubmed: 31546825
Biofabrication. 2021 Mar 16;13(1):011001
pubmed: 33724233
Nat Microbiol. 2017 May 25;2:17082
pubmed: 28540930
Nat Protoc. 2014 Oct;9(10):2329-40
pubmed: 25188634
Cell Res. 2019 Apr;29(4):265-273
pubmed: 30814679
mBio. 2019 Jul 16;10(4):
pubmed: 31311882
PLoS Pathog. 2020 Dec 10;16(12):e1008689
pubmed: 33301527
Cell Host Microbe. 2016 May 11;19(5):720-30
pubmed: 27066744
Sci Rep. 2019 Oct 4;9(1):14336
pubmed: 31586088
Sci Transl Med. 2016 Dec 14;8(369):369ra179
pubmed: 27974667
Virology. 2021 Aug;560:43-53
pubmed: 34023724
Emerg Infect Dis. 2016 May;22(5):933-5
pubmed: 27088323
J Clin Invest. 2018 Oct 1;128(10):4697-4710
pubmed: 30063220
Virology. 2021 Jul;559:100-110
pubmed: 33865073
J Physiol. 2018 Dec;596(23):5665-5674
pubmed: 30325048
Nat Neurosci. 2020 Dec;23(12):1496-1508
pubmed: 33139941
J Infect Dis. 2017 Dec 16;216(suppl_10):S935-S944
pubmed: 29267925
Eur J Pharmacol. 2021 Aug 5;904:174144
pubmed: 33957087
Arch Gynecol Obstet. 2017 Jun;295(6):1361-1368
pubmed: 28396992
Cell Host Microbe. 2017 Feb 8;21(2):134-142
pubmed: 28182948
Lancet. 2018 Feb 10;391(10120):563-571
pubmed: 29217375
Biomaterials. 2021 Jan;268:120556
pubmed: 33310539
Sci Rep. 2020 Dec 1;10(1):20937
pubmed: 33262363
Cell Host Microbe. 2017 Jan 11;21(1):35-46
pubmed: 28081442
Cell. 2017 May 04;169(4):597-609.e11
pubmed: 28475892
N Engl J Med. 2018 Mar 15;378(11):985-994
pubmed: 29539287
EBioMedicine. 2019 Jun;44:516-529
pubmed: 31130472
Trends Cancer. 2021 Mar;7(3):249-264
pubmed: 33218948
Am J Trop Med Hyg. 2016 Jun 1;94(6):1362-1369
pubmed: 27022155
Trends Immunol. 2017 Mar;38(3):194-205
pubmed: 28073693
Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12479-84
pubmed: 21746897
Tissue Barriers. 2018 Jan 2;6(1):e1402143
pubmed: 29370577
Cell Rep. 2020 Feb 4;30(5):1463-1477.e7
pubmed: 32023462
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7852-7
pubmed: 27354515
J Virol. 2008 Jan;82(2):927-37
pubmed: 18003724
Nature. 2016 Dec 15;540(7633):443-447
pubmed: 27819683
PLoS Pathog. 2011 Feb;7(2):e1001297
pubmed: 21379341
Virol J. 2017 Apr 11;14(1):75
pubmed: 28399888
Sci Rep. 2016 Oct 19;6:35296
pubmed: 27759009
Cell. 2017 Sep 21;171(1):229-241.e15
pubmed: 28938115
Cell Stem Cell. 2016 May 5;18(5):587-90
pubmed: 26952870
J Virol. 2008 Apr;82(8):3939-51
pubmed: 18272578
Eur J Med Chem. 2017 Feb 15;127:334-340
pubmed: 28068604
Cell Rep. 2020 Feb 11;30(6):1682-1689.e3
pubmed: 32049002
Front Microbiol. 2017 Dec 22;8:2557
pubmed: 29312238
Front Cell Neurosci. 2019 Mar 15;13:64
pubmed: 30949028
Pathogens. 2021 Feb 13;10(2):
pubmed: 33668558
Sci Rep. 2021 Mar 22;11(1):6492
pubmed: 33753816
Cell Microbiol. 2017 Jun;19(6):
pubmed: 28370966
Cell Stem Cell. 2016 Aug 4;19(2):258-265
pubmed: 27162029
Emerg Infect Dis. 2017 Mar;23(3):405-414
pubmed: 27959260
Immunity. 2017 Mar 21;46(3):446-456
pubmed: 28314593
Cell. 2017 May 4;169(4):610-620.e14
pubmed: 28457610
Viruses. 2020 Aug 25;12(9):
pubmed: 32854298
Viruses. 2020 Dec 29;13(1):
pubmed: 33383826
N Engl J Med. 2017 Feb 14;379(13):1234-1243
pubmed: 28195756
Cytokine. 2020 Jan;125:154864
pubmed: 31577989
Development. 2017 Mar 15;144(6):952-957
pubmed: 28292840
Viruses. 2018 Oct 15;10(10):
pubmed: 30326556
J Infect Dis. 2020 May 11;221(11):1838-1845
pubmed: 31773163
Nat Microbiol. 2020 Jun;5(6):796-812
pubmed: 32367055
Cell. 2016 May 19;165(5):1238-1254
pubmed: 27118425
Cell Host Microbe. 2010 Nov 18;8(5):410-21
pubmed: 21075352
J Gen Virol. 2018 Dec;99(12):1529-1550
pubmed: 30325302
Arch Pathol Lab Med. 2017 Jan;141(1):43-48
pubmed: 27681334
Cell Stem Cell. 2021 Aug 5;28(8):1380-1396.e6
pubmed: 33852917
One Health. 2020 Dec 16;12:100205
pubmed: 33376769
Nat Rev Mol Cell Biol. 2020 Oct;21(10):571-584
pubmed: 32636524
Clin Microbiol Rev. 2016 Jul;29(3):487-524
pubmed: 27029595
Front Microbiol. 2021 Mar 04;12:626370
pubmed: 33746919
Front Neurosci. 2019 Jun 21;13:582
pubmed: 31293366
PLoS Pathog. 2017 Mar 9;13(3):e1006258
pubmed: 28278235
Semin Cell Dev Biol. 2019 Nov;95:93-97
pubmed: 30904636
Nat Rev Microbiol. 2016 Nov;14(11):707-715
pubmed: 27573577
Sci Rep. 2020 Sep 24;10(1):15606
pubmed: 32973223
J Virol. 2006 Oct;80(20):10128-38
pubmed: 17005690
Ann Biomed Eng. 2018 Dec;46(12):1963-1974
pubmed: 30003503
Sci Rep. 2020 Dec 8;10(1):21487
pubmed: 33293587
Nat Med. 2016 Oct;22(10):1101-1107
pubmed: 27571349
Lab Anim (NY). 2020 Jun;49(6):165-168
pubmed: 32398801
Nature. 2016 May 11;534(7606):267-71
pubmed: 27279226
Nat Commun. 2018 Dec 17;9(1):5350
pubmed: 30559387
Cell Stem Cell. 2016 May 5;18(5):591-6
pubmed: 27038591
Stem Cells. 2021 Aug;39(8):1017-1024
pubmed: 33754425
Sci Rep. 2020 May 19;10(1):8263
pubmed: 32427940
Lancet. 2018 Feb 10;391(10120):552-562
pubmed: 29217376
J Med Virol. 1987 Jun;22(2):169-74
pubmed: 2440987
Front Bioeng Biotechnol. 2019 Mar 19;7:39
pubmed: 30941347
Science. 2016 Sep 9;353(6304):1129-32
pubmed: 27492477
Nat Commun. 2020 Aug 12;11(1):4038
pubmed: 32788587
Sci Rep. 2020 Mar 16;10(1):4746
pubmed: 32179788
Cell Rep. 2017 Apr 18;19(3):451-460
pubmed: 28423309
Cell Rep. 2016 Sep 20;16(12):3208-3218
pubmed: 27612415
Cell Death Differ. 2018 Nov;25(10):1837-1854
pubmed: 30050059
Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9433-9438
pubmed: 28784796
EBioMedicine. 2017 Oct;24:189-194
pubmed: 29033372
EBioMedicine. 2016 Dec;14:112-122
pubmed: 27884655
mSystems. 2018 Feb 6;3(1):
pubmed: 29435496
Viruses. 2018 Oct 30;10(11):
pubmed: 30380760
Pediatr Dev Pathol. 2015 Jan-Feb;18(1):30-9
pubmed: 25361230
Cell. 2016 Aug 11;166(4):1016-1027
pubmed: 27475895
Trends Pharmacol Sci. 2021 Feb;42(2):119-133
pubmed: 33341248
Micromachines (Basel). 2021 Jul 27;12(8):
pubmed: 34442506
Nat Mater. 2021 Feb;20(2):156-169
pubmed: 32807924
Stem Cell Reports. 2021 Mar 9;16(3):373-384
pubmed: 33631123
Nat Rev Microbiol. 2021 Aug 25;:
pubmed: 34433930
Nat Rev Immunol. 2021 Jul;21(7):441-453
pubmed: 33398129
Cell Rep. 2017 Apr 18;19(3):558-568
pubmed: 28423319
J Immunol. 2013 Jun 1;190(11):5659-65
pubmed: 23616574
J Gen Virol. 2017 Aug;98(8):2061-2068
pubmed: 28786784
PLoS Pathog. 2017 Jul 26;13(7):e1006537
pubmed: 28746373
Curr Opin Virol. 2018 Apr;29:79-86
pubmed: 29656244
Curr Opin Virol. 2013 Feb;3(1):3-12
pubmed: 23352692
ACS Omega. 2020 May 04;5(19):11217-11226
pubmed: 32455246
Int J Mol Sci. 2020 Dec 22;22(1):
pubmed: 33375140
Autoimmun Rev. 2016 Aug;15(8):801-8
pubmed: 27019049
Virology. 2016 Sep;496:215-218
pubmed: 27344138
Science. 2017 Apr 14;356(6334):175-180
pubmed: 28360135
Annu Rev Med. 2019 Jan 27;70:121-135
pubmed: 30388054
Cell Host Microbe. 2016 May 11;19(5):696-704
pubmed: 27158114
Expert Rev Mol Med. 2008 May 12;10:e12
pubmed: 18471342
Nat Med. 2018 Jun;24(6):721-723
pubmed: 29867228
J Virol. 2017 Jan 31;91(4):
pubmed: 27974560
mBio. 2019 Jul 2;10(4):
pubmed: 31266863
PLoS Pathog. 2020 Jul 2;16(7):e1008601
pubmed: 32614902
Sci Rep. 2017 Nov 17;7(1):15771
pubmed: 29150641
Nat Rev Immunol. 2018 Jun;18(6):390-404
pubmed: 29556017
Sci Rep. 2017 Jun 30;7(1):4475
pubmed: 28667332
Front Immunol. 2020 Sep 01;11:2146
pubmed: 32983175
Nat Rev Microbiol. 2018 Oct;16(10):594-600
pubmed: 29921914
mBio. 2016 Jul 19;7(4):
pubmed: 27435464
ACS Infect Dis. 2019 Dec 13;5(12):1976-1979
pubmed: 31580050
Prog Neurobiol. 2021 Sep;204:102111
pubmed: 34166774
J Proteome Res. 2020 Nov 6;19(11):4259-4274
pubmed: 33095583
Viruses. 2018 Apr 16;10(4):
pubmed: 29659541
Cell Discov. 2018 Jun 5;4:31
pubmed: 29872540
Cell Rep. 2017 Oct 10;21(2):517-532
pubmed: 29020636
J Virol. 2020 Jan 6;94(2):
pubmed: 31666384
Virology. 2017 Jul;507:89-95
pubmed: 28431283
Nat Biotechnol. 2018 Jun;36(5):432-441
pubmed: 29658944
Sci Rep. 2020 Jan 27;10(1):1218
pubmed: 31988337
EBioMedicine. 2016 Oct;12:161-169
pubmed: 27688094
Cell Stem Cell. 2021 Aug 5;28(8):1362-1379.e7
pubmed: 33838105
PLoS Negl Trop Dis. 2016 May 05;10(5):e0004658
pubmed: 27149521
Cell Stem Cell. 2016 Nov 3;19(5):593-598
pubmed: 27545505
J Gen Virol. 2007 Feb;88(Pt 2):365-375
pubmed: 17251552