Stereoselective Synthesis of the Di-Spirooxindole Analogs Based Oxindole and Cyclohexanone Moieties as Potential Anticancer Agents.
Antineoplastic Agents
/ chemical synthesis
Cell Line
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cyclohexanones
/ chemistry
Drug Screening Assays, Antitumor
/ methods
Fibroblasts
/ drug effects
HeLa Cells
Humans
MCF-7 Cells
Molecular Docking Simulation
Oxindoles
/ chemistry
PC-3 Cells
Spiro Compounds
/ chemistry
Structure-Activity Relationship
[3+2] cycloaddition reaction
anti-cancer activity
azomethine ylides
spirooxindole
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
19 Oct 2021
19 Oct 2021
Historique:
received:
22
06
2021
revised:
14
10
2021
accepted:
15
10
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
18
11
2021
Statut:
epublish
Résumé
A new series of di-spirooxindole analogs, engrafted with oxindole and cyclohexanone moieties, were synthesized. Initially, azomethine ylides were generated via reaction of the substituted isatins
Identifiants
pubmed: 34684885
pii: molecules26206305
doi: 10.3390/molecules26206305
pmc: PMC8541513
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Cyclohexanones
0
Oxindoles
0
Spiro Compounds
0
cyclohexanone
5QOR3YM052
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : King Abdulaziz City for Science and Technology
ID : 14-BIO128-02
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