C1431T Variant of PPARγ Is Associated with Preeclampsia in Pregnant Women.
PPARγ
SNPs
machine learning
models
preeclampsia
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
07 Oct 2021
07 Oct 2021
Historique:
received:
13
08
2021
revised:
01
10
2021
accepted:
02
10
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
24
10
2021
Statut:
epublish
Résumé
Peroxisome proliferator-activated receptor γ (PPARγ) is essential for placental development, whose SNPs have shown increased susceptibility to pregnancy-related diseases, such as preeclampsia. Our aim was to investigate the association between preeclampsia and three PPARγ SNPs (Pro12Ala, C1431T, and C681G), which together with nine clinical factors were used to build a pragmatic model for preeclampsia prediction. Data were collected from 1648 women from the EDEN cohort, of which 35 women had preeclamptic pregnancies, and the remaining 1613 women had normal pregnancies. Univariate analysis comparing preeclamptic patients to the control resulted in the SNP C1431T being the only factor significantly associated with preeclampsia (
Identifiants
pubmed: 34685423
pii: life11101052
doi: 10.3390/life11101052
pmc: PMC8540421
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : China Scholarship Council
ID : 201806270256
Organisme : Campus France
ID : 969976G
Organisme : the European Union FP7 Programme
ID : FP7/2007-2013
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