Intracoronary Delivery of Porcine Cardiac Progenitor Cells Overexpressing IGF-1 and HGF in a Pig Model of Sub-Acute Myocardial Infarction.
HGF
IGF-1
cardiac progenitor cell
decellularized extracellular matrix
lentiviral vectors
myocardial infarction
porcine large animal model
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
28 09 2021
28 09 2021
Historique:
received:
10
07
2021
revised:
17
09
2021
accepted:
24
09
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
6
1
2022
Statut:
epublish
Résumé
Human cardiac progenitor cells (hCPC) are considered a good candidate in cell therapy for ischemic heart disease, demonstrating capacity to improve functional recovery after myocardial infarction (MI), both in small and large preclinical animal models. However, improvements are required in terms of cell engraftment and efficacy. Based on previously published reports, insulin-growth factor 1 (IGF-1) and hepatocyte growth factor (HGF) have demonstrated substantial cardioprotective, repair and regeneration activities, so they are good candidates to be evaluated in large animal model of MI. We have validated porcine cardiac progenitor cells (pCPC) and lentiviral vectors to overexpress IGF-1 (co-expressing eGFP) and HGF (co-expressing mCherry). pCPC were transduced and IGF1-eGFP
Identifiants
pubmed: 34685551
pii: cells10102571
doi: 10.3390/cells10102571
pmc: PMC8534140
pii:
doi:
Substances chimiques
Hepatocyte Growth Factor
67256-21-7
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Sixth Framework Programme
ID : HEALTH-2009_242038
Organisme : Instituto de Salud Carlos III
ID : RD16/0011/0037
Organisme : Instituto de Salud Carlos III
ID : CB16/11/00403
Organisme : Ministerio de Ciencia e Innovación
ID : RTI2018-097604-B-I00
Organisme : Comunidad Autónoma de Madrid
ID : S2017/BMD-3692
Organisme : Instituto de Salud Carlos III
ID : RETICS-RTI2018-097604-B-I00; PIC18/00014 and PI20/00247
Organisme : Spanish Cell Therapy Network (TerCel)
ID : RD16/0011/0006
Références
FEBS Lett. 2000 Jul 7;476(3):218-23
pubmed: 10913617
Acta Histochem. 2017 May;119(4):400-406
pubmed: 28457660
Nat Med. 2008 Feb;14(2):213-21
pubmed: 18193059
Mol Med Rep. 2017 Jul;16(1):787-793
pubmed: 28560388
Nat Clin Pract Cardiovasc Med. 2007 Feb;4 Suppl 1:S52-9
pubmed: 17230216
Cell. 2003 Sep 19;114(6):763-76
pubmed: 14505575
Stem Cell Res Ther. 2016 Jul 16;7(1):94
pubmed: 27423905
Cell Death Differ. 2017 Dec;24(12):2101-2116
pubmed: 28800128
Nature. 2013 Jan 17;493(7432):433-6
pubmed: 23222518
Pharmacol Ther. 2017 Mar;171:1-12
pubmed: 27916652
Sci Rep. 2019 Mar 15;9(1):4647
pubmed: 30874584
Trends Endocrinol Metab. 2014 Mar;25(3):128-37
pubmed: 24380833
Onco Targets Ther. 2020 Jul 03;13:6453-6463
pubmed: 32753886
Circulation. 2017 Aug 15;136(7):680-686
pubmed: 28684531
J Am Coll Cardiol. 2014 Jan 21;63(2):110-22
pubmed: 24036024
Biochem Biophys Res Commun. 2007 Nov 23;363(3):674-9
pubmed: 17904522
Circ Res. 2010 Mar 19;106(5):971-80
pubmed: 20110532
J Am Coll Cardiol. 2011 Aug 23;58(9):977-86
pubmed: 21723061
Circulation. 2013 Dec 24;128(25):2764-75
pubmed: 24061088
Cell Rep. 2014 Jul 10;8(1):229-41
pubmed: 25001281
PLoS One. 2012;7(2):e32191
pubmed: 22363814
Free Radic Biol Med. 2001 Oct 1;31(7):902-10
pubmed: 11585709
Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1446-51
pubmed: 23302686
J Am Coll Cardiol. 2016 Dec 6;68(22):2454-2464
pubmed: 27908351
Cell. 2013 Aug 15;154(4):827-42
pubmed: 23953114
Eur J Heart Fail. 2010 Jul;12(7):730-7
pubmed: 20406797
Biomaterials. 2015 Aug;61:279-89
pubmed: 26005766
Cell Prolif. 2015 Dec;48(6):661-70
pubmed: 26466964
Stem Cell Reports. 2013 Oct 24;1(5):397-410
pubmed: 24286028
Mayo Clin Proc. 2014 Jun;89(6):850-8
pubmed: 24943699
Sci Rep. 2020 Apr 28;10(1):7166
pubmed: 32346015
Circulation. 2013 Jul 9;128(2):122-31
pubmed: 23757309
Eur Heart J. 2020 Sep 21;41(36):3451-3458
pubmed: 32749459
J Clin Invest. 2009 Aug;119(8):2204-17
pubmed: 19620770
PLoS One. 2014 May 07;9(5):e96725
pubmed: 24806457
Cardiovasc Res. 2018 Jun 1;114(7):992-1005
pubmed: 29518183
Cytotherapy. 2006;8(4):315-7
pubmed: 16923606
Cardiovasc Res. 2014 Nov 1;104(2):290-302
pubmed: 25213554
Biomedicines. 2014 Oct 21;2(4):247-262
pubmed: 28548070
Anticancer Res. 2019 Feb;39(2):597-607
pubmed: 30711935
Stem Cell Res Ther. 2020 Jan 9;11(1):22
pubmed: 31918758
Hum Cell. 2015 Apr;28(2):73-80
pubmed: 25471296
BMC Genomics. 2014 Aug 27;15:724
pubmed: 25163646
Expert Opin Ther Targets. 2019 Feb;23(2):127-142
pubmed: 30556751
Biomaterials. 2015 Mar;45:56-63
pubmed: 25662495
Stem Cell Res Ther. 2019 May 31;10(1):152
pubmed: 31151405
Sci Rep. 2017 Oct 2;7(1):12490
pubmed: 28970523
Stem Cells. 2014 Jun;32(6):1493-502
pubmed: 24496962
Circ Res. 2017 Apr 28;120(9):1487-1500
pubmed: 28450366
J Cell Sci. 2001 Feb;114(Pt 3):539-47
pubmed: 11171323
EMBO Rep. 2001 Sep;2(9):800-7
pubmed: 11520856
Regen Med. 2009 Nov;4(6):835-53
pubmed: 19903003
Cardiovasc Res. 2001 Jul;51(1):41-50
pubmed: 11399246
J Recept Signal Transduct Res. 2004 Feb;24(1-2):85-105
pubmed: 15344881
Circulation. 2009 Sep 22;120(12):1075-83, 7 p following 1083
pubmed: 19738142
Circ Res. 2015 Feb 13;116(4):653-64
pubmed: 25403163
Stem Cell Reports. 2014 Dec 9;3(6):1029-42
pubmed: 25465869
J Tissue Eng Regen Med. 2016 Jul;10(7):580-90
pubmed: 23897803
Circulation. 2010 Jan 19;121(2):293-305
pubmed: 20048209
Hum Gene Ther. 2012 Mar;23(3):255-61
pubmed: 22017392
Circulation. 2019 Jun 4;139(23):2668-2684
pubmed: 30832495
Circ Res. 2013 Feb 1;112(3):451-64
pubmed: 23243206
Dev Cell. 2019 Mar 25;48(6):765-779.e7
pubmed: 30773489
Circulation. 2012 Jan 3;125(1):100-12
pubmed: 22086878
J Biomed Res. 2010 May;24(3):198-206
pubmed: 23554631
Circulation. 2012 Sep 11;126(11 Suppl 1):S54-64
pubmed: 22965994
Circ Res. 2018 Aug 17;123(5):579-589
pubmed: 29921651
Cell Stem Cell. 2020 Jan 2;26(1):81-96.e4
pubmed: 31883835
Lancet. 2012 Mar 10;379(9819):895-904
pubmed: 22336189
Clin Sci (Lond). 2015 Oct;129(7):575-88
pubmed: 25994236
J Biomed Mater Res A. 2015 Sep;103(9):3012-25
pubmed: 25727843
PLoS One. 2014 Oct 31;9(10):e111246
pubmed: 25360679
Nature. 2019 May;569(7756):418-422
pubmed: 31068698
J Transl Med. 2015 May 12;13:156
pubmed: 25964098
Stem Cell Rev Rep. 2019 Dec;15(6):892-899
pubmed: 31520298
Cell Stem Cell. 2008 Apr 10;2(4):320-31
pubmed: 18397752
Circ Res. 2017 Jun 23;121(1):71-80
pubmed: 28533209
Circ Res. 2016 Apr 15;118(8):1223-32
pubmed: 26888636
Cell Transplant. 2016;25(9):1609-1622
pubmed: 26624235
Nature. 2014 Aug 21;512(7514):319-23
pubmed: 25119047
Am J Transl Res. 2016 Nov 15;8(11):4605-4627
pubmed: 27904666
EMBO Mol Med. 2014 May 05;6(6):760-77
pubmed: 24797668