The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of Growth.
GHRH
IGF-1 singalling
adipose tissues physiology
energy expenditure
growth hormone
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
05 10 2021
05 10 2021
Historique:
received:
23
08
2021
revised:
30
09
2021
accepted:
03
10
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
15
12
2021
Statut:
epublish
Résumé
In mammals, the neuroendocrine system, which includes the communication between the hypothalamus and the pituitary, plays a major role in controlling body growth and cellular metabolism. GH produced from the pituitary somatotroph is considered the master regulator of somatic development and involved, directly and indirectly, in carbohydrate and lipid metabolism via complex, yet well-defined, signaling pathways. GH production from the pituitary gland is primarily regulated by the counter-regulatory effects of the hypothalamic GHRH and SST hormones. The role of IGF-1 feedback regulation in GH production has been demonstrated by pharmacologic interventions and in genetically modified mouse models. In the present review, we discuss the role of IGF-1 in the regulation of the GH-axis as it controls somatic growth and metabolic homeostasis. We present genetically modified mouse models that maintain the integrity of the GH/GHRH-axis with the single exception of IGF-1 receptor (IGF-1R) deficiency in the hypothalamic GHRH neurons and somatotroph that reveals a novel mechanism controlling adipose tissues physiology and energy expenditure.
Identifiants
pubmed: 34685644
pii: cells10102664
doi: 10.3390/cells10102664
pmc: PMC8534318
pii:
doi:
Substances chimiques
Insulin-Like Growth Factor I
67763-96-6
Receptor, IGF Type 1
EC 2.7.10.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NICHD NIH HHS
ID : U01 HD086838
Pays : United States
Références
J Biol Chem. 1989 Jul 15;264(20):11843-8
pubmed: 2473065
Nat Commun. 2018 Jun 19;9(1):2394
pubmed: 29921922
Nat Rev Mol Cell Biol. 2007 Sep;8(9):681-91
pubmed: 17684529
Science. 1997 Aug 15;277(5328):942-6
pubmed: 9252323
Cells. 2020 Jun 02;9(6):
pubmed: 32498386
Acta Endocrinol (Copenh). 1989 Dec;121(6):753-8
pubmed: 2558477
Immun Ageing. 2016 May 01;13:15
pubmed: 27134635
J Mol Endocrinol. 2018 Jul;61(1):T69-T86
pubmed: 29535161
Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7324-9
pubmed: 10377413
Endocrinol Metab Clin North Am. 2012 Jun;41(2):231-47, v
pubmed: 22682628
Biochem J. 1992 Jul 1;285 ( Pt 1):269-74
pubmed: 1637311
Intern Med. 2002 Jan;41(1):7-13
pubmed: 11838603
Med J Islam Repub Iran. 2019 Jun 17;33:56
pubmed: 31456980
Aging Dis. 2010 Oct 1;1(2):72-74
pubmed: 21132086
Mol Genet Metab. 2001 May;73(1):1-10
pubmed: 11350177
Endocr Rev. 1997 Dec;18(6):801-31
pubmed: 9408744
Nature. 2001 Nov 22;414(6862):412
pubmed: 11719795
Biochem Insights. 2019 Apr 17;12:1178626419842176
pubmed: 31024217
Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13215-20
pubmed: 9371826
Int J Mol Sci. 2014 Apr 11;15(4):6184-223
pubmed: 24733068
Genes Dev. 2001 Aug 1;15(15):1926-34
pubmed: 11485987
J Mol Endocrinol. 2018 Jul;61(1):T11-T28
pubmed: 29255001
Endocrinol Metab Clin North Am. 2012 Jun;41(2):425-43, vii-viii
pubmed: 22682639
N Engl J Med. 1997 Feb 27;336(9):633-40
pubmed: 9032050
Nat Rev Drug Discov. 2007 Oct;6(10):821-33
pubmed: 17906644
Int J Mol Sci. 2017 Jul 05;18(7):
pubmed: 28678199
Mol Cell Biol. 1997 Mar;17(3):1595-606
pubmed: 9032287
Eur J Neurosci. 2007 Jan;25(1):191-200
pubmed: 17241280
PLoS One. 2017 Jan 11;12(1):e0170083
pubmed: 28076448
Endocrinology. 2000 Apr;141(4):1287-8
pubmed: 10746630
J Clin Endocrinol Metab. 2004 Jul;89(7):3543-53
pubmed: 15240644
Exp Gerontol. 2000 Sep;35(6-7):879-96
pubmed: 11053678
Best Pract Res Clin Endocrinol Metab. 2011 Feb;25(1):101-13
pubmed: 21396577
Nature. 1972 Jan 14;235(5333):107
pubmed: 4550398
Horm Res. 2004;62 Suppl 1:77-82
pubmed: 15761237
Bone Res. 2013 Sep 25;1(3):249-59
pubmed: 26273506
Nature. 1993 Dec 2;366(6454):461-4
pubmed: 8247153
Front Endocrinol (Lausanne). 2019 Feb 01;10:27
pubmed: 30774624
J Biol Chem. 2002 Apr 19;277(16):13620-7
pubmed: 11834727
Aging Dis. 2010 Oct;1(2):147-57
pubmed: 22396862
Endocr Rev. 2002 Dec;23(6):824-54
pubmed: 12466191
Elife. 2021 Apr 01;10:
pubmed: 33792539
Metabolism. 2016 Apr;65(4):557-68
pubmed: 26975547
Ann Pediatr Endocrinol Metab. 2017 Sep;22(3):145-152
pubmed: 29025199
FEBS Lett. 1978 May 15;89(2):283-6
pubmed: 658418
Mol Biol Cell. 2016 Aug 15;27(16):2523-7
pubmed: 27528697
Proc Natl Acad Sci U S A. 1929 Sep 15;15(9):733-4
pubmed: 16577229
Best Pract Res Clin Endocrinol Metab. 2017 Feb;31(1):113-125
pubmed: 28477727
Trends Endocrinol Metab. 2020 Sep;31(9):642-654
pubmed: 32416957
Mol Metab. 2019 Jan;19:86-96
pubmed: 30392760
Front Endocrinol (Lausanne). 2018 Aug 30;9:499
pubmed: 30214426
Signal Transduct Target Ther. 2019 Feb 8;4:3
pubmed: 30775002
Stress. 2018 Sep;21(5):403-416
pubmed: 29764284
Cell. 1993 Oct 8;75(1):59-72
pubmed: 8402901
Pediatr Endocrinol Rev. 2018 Sep;16(Suppl 1):39-62
pubmed: 30378782
Diabetes. 2016 Aug;65(8):2201-13
pubmed: 27207537
Growth Horm IGF Res. 2008 Dec;18(6):455-71
pubmed: 18710818
J Cell Biochem. 1999;Suppl 32-33:59-67
pubmed: 10629104
Diabetes. 2008 Aug;57(8):2074-82
pubmed: 18443199
Endocr Rev. 2011 Jun;32(3):356-86
pubmed: 21123740
Aging Dis. 2010 Oct;1(2):139-46
pubmed: 22396861
Adv Exp Med Biol. 1993;343:1-11
pubmed: 8184730
Mol Endocrinol. 2010 May;24(5):1077-89
pubmed: 20211984
Acta Diabetol. 2011 Mar;48(1):1-9
pubmed: 21042815
Nat Rev Endocrinol. 2013 Jun;9(6):366-376
pubmed: 23591370
Endocrinology. 2013 Jul;154(7):2410-20
pubmed: 23671263
Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):435-44
pubmed: 14604834
Alcohol Health Res World. 1998;22(3):153-64
pubmed: 15706790
Nutr Diabetes. 2017 Dec 19;7(12):2
pubmed: 29259155
Diabetes. 2001 May;50(5):1110-8
pubmed: 11334415
Endocr Rev. 1995 Feb;16(1):3-34
pubmed: 7758431
Diabetes. 2021 Oct;70(10):2237-2249
pubmed: 34285117
FEBS Lett. 1986 Sep 1;205(1):15-9
pubmed: 3017755
Endocrinology. 1995 Apr;136(4):1635-41
pubmed: 7895674
Endocrinology. 2019 Jul 1;160(7):1743-1756
pubmed: 31099824
Endocrinology. 2009 Jan;150(1):314-23
pubmed: 18801897
Front Cell Neurosci. 2017 Feb 01;11:14
pubmed: 28203146
J Mol Endocrinol. 2018 Jul;61(1):T187-T198
pubmed: 29743295
Cell Tissue Res. 2019 Jan;375(1):23-39
pubmed: 29869716
PLoS Biol. 2008 Oct 28;6(10):e254
pubmed: 18959478
Neuroscience. 1992;46(4):909-23
pubmed: 1311816
Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E405-13
pubmed: 15138153
N Engl J Med. 2000 Jun 1;342(22):1633-7
pubmed: 10833209