Lysosomal Zn
Animals
Antineoplastic Agents
/ pharmacology
Cell Death
Cell Line, Tumor
Female
Gene Expression Regulation, Neoplastic
HEK293 Cells
Humans
Lysosomes
/ drug effects
Melanocytes
/ drug effects
Melanoma
/ drug therapy
Mice, Nude
Mitochondria
/ drug effects
Signal Transduction
Skin Neoplasms
/ drug therapy
Time Factors
Transient Receptor Potential Channels
/ agonists
Up-Regulation
Xenograft Model Antitumor Assays
Zinc
/ metabolism
ML-SAs
ML-SIs
TRPML1
Zn(2+)
cell death
lysosome
metastatic melanoma
mitochondria
small molecule
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
19 10 2021
19 10 2021
Historique:
received:
01
12
2020
revised:
16
08
2021
accepted:
27
09
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
16
2
2022
Statut:
ppublish
Résumé
During tumor progression, lysosome function is often maladaptively upregulated to match the high energy demand required for cancer cell hyper-proliferation and invasion. Here, we report that mucolipin TRP channel 1 (TRPML1), a lysosomal Ca
Identifiants
pubmed: 34686351
pii: S2211-1247(21)01312-7
doi: 10.1016/j.celrep.2021.109848
pmc: PMC8559338
mid: NIHMS1749762
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
MCOLN1 protein, human
0
Transient Receptor Potential Channels
0
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM
Pagination
109848Subventions
Organisme : NCI NIH HHS
ID : R21 CA252428
Pays : United States
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests H.X. is the scientific cofounder and partial owner of CalyGene Biotechnology, Inc. and Lysoway Therapeutics, Inc. and an inventor of the US Provisional Patent Application No. 62/894,289. All other authors declare no competing interests.
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