M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis.
cell biology
pain
rheumatology
statistics
Journal
Archives of disease in childhood
ISSN: 1468-2044
Titre abrégé: Arch Dis Child
Pays: England
ID NLM: 0372434
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
23
03
2021
accepted:
06
09
2021
pubmed:
24
10
2021
medline:
13
4
2022
entrez:
23
10
2021
Statut:
ppublish
Résumé
Distinction on clinical grounds between acute lymphoblastic leukaemia presenting with arthropathy (ALL In this observational study, we measured M-ficolin, CL-K1 and MASP-3 in serum from children with ALL (n=151) and JIA (n=238) by time-resolved immunofluorometric assays. Logistic regression was used for predictions of ALL risk, considering the markers as the respective exposures. We performed internal validation using repeated '10-fold cross-validation' with 100 repetitions computing the area under the curve (AUC) as well as positive and negative predictive values in order to evaluate the predictive performance. The level of M-ficolin was higher in JIA than ALL M-ficolin is a valuable marker to differentiate the child with ALL from JIA.
Identifiants
pubmed: 34686494
pii: archdischild-2021-322114
doi: 10.1136/archdischild-2021-322114
pmc: PMC8938675
doi:
Substances chimiques
Biomarkers
0
Lectins
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
371-376Informations de copyright
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Immunobiology. 2016 Oct;221(10):1058-67
pubmed: 27377710
Pediatr Allergy Immunol. 2011 Jun;22(4):424-30
pubmed: 21226765
Scand J Immunol. 2013 Aug;78(2):181-93
pubmed: 23672641
Pediatrics. 2006 May;117(5):e840-4
pubmed: 16651289
Arch Dis Child. 2015 Sep;100(9):821-5
pubmed: 26216831
Mol Immunol. 2007 Sep;44(16):3875-88
pubmed: 17768106
J Immunol Methods. 2010 Sep 30;361(1-2):37-50
pubmed: 20673767
Arthritis Care Res (Hoboken). 2020 Apr;72(4):507-516
pubmed: 30762291
EMBO J. 2015 Nov 12;34(22):2735-57
pubmed: 26489954
Intern Med J. 2005 Sep;35(9):548-55
pubmed: 16105157
J Rheumatol. 2004 Feb;31(2):390-2
pubmed: 14760812
Clin Rheumatol. 2017 Mar;36(3):671-676
pubmed: 28097448
J Rheumatol. 2015 Jul;42(7):1252-8
pubmed: 26034144
Ann Hematol. 2010 Mar;89(3):249-54
pubmed: 19727722
Clin Rheumatol. 2018 Sep;37(9):2455-2463
pubmed: 29464526
J Immunol Methods. 2012 Jan 31;375(1-2):182-8
pubmed: 22301270
J Innate Immun. 2010;2(2):167-80
pubmed: 20375634
PLoS One. 2020 Aug 11;15(8):e0237530
pubmed: 32780759
Int J Biochem Cell Biol. 2011 May;43(5):705-12
pubmed: 21315829
Pediatr Rheumatol Online J. 2019 Sep 9;17(1):63
pubmed: 31500626
Immunol Cell Biol. 2017 Sep;95(8):666-675
pubmed: 28405017
J Pediatr Orthop. 2008 Jan-Feb;28(1):20-8
pubmed: 18157042
Immunobiology. 2011 May;216(5):633-8
pubmed: 21112665
Clin Rheumatol. 2009 Nov;28(11):1253-8
pubmed: 19621208
J Immunol. 2005 Sep 1;175(5):3150-6
pubmed: 16116205