Prevalence and factors associated with diabetes mellitus among tuberculosis patients in South India-a cross-sectional analytical study.
diabetes & endocrinology
epidemiology
tuberculosis
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
22 10 2021
22 10 2021
Historique:
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
4
11
2021
Statut:
epublish
Résumé
To determine the prevalence and determinants of diabetes mellitus (DM) among tuberculosis (TB) patients and to assess the additional yield and number needed to screen (NNS) to obtain a newly diagnosed DM among TB patients. We undertook a cross-sectional analysis of the cohort data under Regional Prospective Observational Research for Tuberculosis-India consortium. Newly diagnosed TB patients recruited into the cohort between 2014 and 2018 were included. Pretested standardised questionnaires and tools were used for data collection. Prevalence of DM among TB patients was summarised as proportion with 95% CI. Type II DM was diagnosed if random blood sugar level was >200 mg/dL or if the participant had a documented history of DM. NNS by blood glucose testing to diagnose one new DM case among TB patients was also calculated. Three districts of South India: Puducherry, Cuddalore and Villupuram SUBJECTS: Newly diagnosed sputum smear positive pulmonary TB patients aged ≥16 years RESULTS: In total, 1188 TB patients were included. Prevalence of DM among TB patients was 39% (95% CI: 36.2% to 41.8%). In unadjusted analysis, elderly TB, marital status, caste, gender, higher education level, household income and obesity had a significant association with DM. However, in adjusted analysis, only marital status (currently married aPR; 3.77 (95 CI: 2.20 to 6.49), widowed/separated/divorced aPR; 3.66 (95 CI: 1.96 to 6.83)) and body mass index category (normal weight aPR; 3.26 (95 CI: 2.55 to 4.16), overweight aPR; 3.86 (95 CI: 2.69 to 5.52), obesity aPR; 4.08 (95 CI: 2.81 to 5.94)) were found to be significant determinants. The number of TB patients needed to be screened to find a new DM case was 12. We found that one in three TB patients had coexisting DM. The number of TB patients needed to be screened to obtain a newly diagnosed DM patients was also determined. The study supports and highlights the need of RNTCP's effort in bidirectional screening of TB and DM.
Identifiants
pubmed: 34686553
pii: bmjopen-2021-050542
doi: 10.1136/bmjopen-2021-050542
pmc: PMC8543642
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e050542Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Clin Infect Dis. 2015 Oct 15;61Suppl 3:S155-9
pubmed: 26409277
Diabetes Care. 2020 Nov;43(11):2643-2650
pubmed: 32873587
Arch Intern Med. 2007 Jun 25;167(12):1297-304
pubmed: 17592104
Iran J Med Sci. 2017 Mar;42(2):144-151
pubmed: 28360440
BMC Infect Dis. 2019 Oct 17;19(1):859
pubmed: 31623569
J Nucl Med. 1994 Feb;35(2):204-6
pubmed: 8294985
Public Health Action. 2015 Jun 21;5(2):147-9
pubmed: 26400387
Lancet Glob Health. 2019 Apr;7(4):e448-e460
pubmed: 30819531
PLoS One. 2019 Mar 27;14(3):e0214011
pubmed: 30917170
Glob Health Action. 2017;10(1):1-11
pubmed: 28245710
PLoS One. 2016 Jan 25;11(1):e0147621
pubmed: 26808967
Antimicrob Agents Chemother. 2013 Nov;57(11):5740-2
pubmed: 23979746
Lancet. 2004 Jan 10;363(9403):157-63
pubmed: 14726171
Trans R Soc Trop Med Hyg. 2015 Jun;109(6):400-7
pubmed: 25918218
Diabetes Res Clin Pract. 2014 Feb;103(2):137-49
pubmed: 24630390
BMC Infect Dis. 2018 Nov 29;18(1):603
pubmed: 30497410
PLoS One. 2011;6(8):e24215
pubmed: 21912626
Public Health Action. 2013 Nov 4;3(Suppl 1):S38-42
pubmed: 26393068
Public Health Action. 2013 Nov 4;3(Suppl 1):S43-7
pubmed: 26393069
Diabetes Res Clin Pract. 2013 Jul;101(1):10-9
pubmed: 23305899
BMC Infect Dis. 2019 Jul 16;19(1):627
pubmed: 31311495
J Biosoc Sci. 2021 Sep;53(5):758-772
pubmed: 32959732
J Thorac Dis. 2017 Feb;9(2):E121-E125
pubmed: 28275494
PLoS One. 2012;7(7):e41367
pubmed: 22848473
Trop Med Int Health. 2017 Apr;22(4):465-473
pubmed: 28102021
J Clin Tuberc Other Mycobact Dis. 2018 Apr 10;12:9-13
pubmed: 31720392
Int J Epidemiol. 2013 Feb;42(1):221-7
pubmed: 23064501
PLoS Med. 2008 Jul 15;5(7):e152
pubmed: 18630984
Int J Tuberc Lung Dis. 2017 Dec 1;21(12):1214-1219
pubmed: 29297440
PLoS One. 2009 May 28;4(5):e5718
pubmed: 19479058
Public Health Action. 2013 Nov 4;3(Suppl 1):S51-3
pubmed: 26393071
N Am J Med Sci. 2014 Jan;6(1):30-4
pubmed: 24678474
PLoS One. 2017 Aug 23;12(8):e0183195
pubmed: 28832615
Infez Med. 2018 Mar 1;26(1):22-27
pubmed: 29525794
Public Health Action. 2013 Nov 4;3(Suppl 1):S29-33
pubmed: 26393065
PLoS One. 2013 Dec 18;8(12):e82660
pubmed: 24367535
Lancet Diabetes Endocrinol. 2017 Aug;5(8):585-596
pubmed: 28601585
PLoS One. 2017 Apr 21;12(4):e0175925
pubmed: 28430796
Trop Med Health. 2015 Mar;43(1):1-9
pubmed: 25859149
Glob Health Action. 2014 May 19;7:24022
pubmed: 24845213
Am J Trop Med Hyg. 2017 Oct;97(4):1099-1102
pubmed: 28820679
Eur Respir J. 2010 Nov;36(5):1185-206
pubmed: 20530046
BMC Infect Dis. 2017 Aug 15;17(1):567
pubmed: 28806911
Clin Infect Dis. 2006 Oct 1;43(7):848-54
pubmed: 16941365