Reduced age-related gray matter loss in the subgenual cingulate cortex in long-term meditators.
Aging
Cingulate Cortex
Gray Matter
MRI
Meditation
Mindfulness
Subgenual Cortex
Journal
Brain imaging and behavior
ISSN: 1931-7565
Titre abrégé: Brain Imaging Behav
Pays: United States
ID NLM: 101300405
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
accepted:
29
09
2021
pubmed:
24
10
2021
medline:
19
1
2022
entrez:
23
10
2021
Statut:
ppublish
Résumé
Accumulating evidence suggests that meditation practices have positive effects on brain ageing overall. The cingulate is known to be recruited during meditation, but research into possible effects of meditation on the ageing of the cingulate is currently missing. Thus, the present study was designed to help close this knowledge gap, with particular focus on the subgenual cingulate, a region involved in emotional regulation and autonomic and endocrine functions, making it potentially relevant for meditation. Here, we investigated differences in age-related gray matter loss between 50 long-term meditation practitioners (28 male, 22 female), aged between 24 and 77, and 50 age- and sex-matched controls. Areas of interest were four subregions of the subgenual cingulate gyrus (areas 25, 33, s24, and s32) defined as per the Julich-Brain atlas. Our study revealed a significant age-related decline in all subregions in both meditators and controls, but with significantly lower rates of annual tissue loss in meditators, specifically in left and right area s32 and right area 25. These regions have been shown to play a role in mood regulation, autonomic processing, and the integration of emotion and cognitive processes, which are all involved in and impacted by meditation. Overall, the results add further evidence to the emerging notion that meditation may slow the effects of ageing on the brain.
Identifiants
pubmed: 34686969
doi: 10.1007/s11682-021-00578-6
pii: 10.1007/s11682-021-00578-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2824-2832Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Amunts, K., Mohlberg, H., Bludau, S., & Zilles, K. (2020). Julich-Brain: A 3D probabilistic atlas of the human brain’s cytoarchitecture. Science, 369(6506), 988–992. https://doi.org/10.1126/science.abb4588
doi: 10.1126/science.abb4588
pubmed: 32732281
Ashburner, J., & Friston, K. J. (2000). Voxel-based morphometry–the methods. NeuroImage, 11(6 Pt 1), 805–821. https://doi.org/10.1006/nimg.2000.0582
doi: 10.1006/nimg.2000.0582
pubmed: 10860804
Ashburner, J., & Friston, K. J. (2011). Diffeomorphic registration using geodesic shooting and Gauss-Newton optimisation. NeuroImage, 55(3), 954–967. https://doi.org/10.1016/j.neuroimage.2010.12.049
doi: 10.1016/j.neuroimage.2010.12.049
pubmed: 21216294
Beckmann, M., Johansen-Berg, H., & Rushworth, M. F. (2009). Connectivity-based parcellation of human cingulate cortex and its relation to functional specialization. Journal of Neuroscience, 29(4), 1175–1190. https://doi.org/10.1523/JNEUROSCI.3328-08.2009
doi: 10.1523/JNEUROSCI.3328-08.2009
pubmed: 19176826
Benjamini, Y., & Yekutieli, D. (2001). The control of the false discovery rate in multiple testing under dependency. Annals of Statistics, 29(4), 1165–1188.
doi: 10.1214/aos/1013699998
Bergfield, K. L., Hanson, K. D., Chen, K., Teipel, S. J., Hampel, H., Rapoport, S. I., ..., Alexander, G. E. (2010). Age-related networks of regional covariance in MRI gray matter: reproducible multivariate patterns in healthy aging. Neuroimage, 49(2), 1750-1759. https://doi.org/10.1016/j.neuroimage.2009.09.051
Cao, W., Luo, C., Zhu, B., Zhang, D., Dong, L., Gong, J., ..., Yao, D. (2014). Resting-state functional connectivity in anterior cingulate cortex in normal aging. Frontiers in Aging Neuroscience, 6, 280. https://doi.org/10.3389/fnagi.2014.00280
Chan, J. S. Y., Deng, K., Wu, J., & Yan, J. H. (2019). Effects of Meditation and Mind-Body Exercises on Older Adults’ Cognitive Performance: A Meta-analysis. The Gerontologist, 59(6), e782–e790. https://doi.org/10.1093/geront/gnz022
doi: 10.1093/geront/gnz022
pubmed: 30796782
Chetelat, G., Mezenge, F., Tomadesso, C., Landeau, B., Arenaza-Urquijo, E., Rauchs, G., ..., Lutz, A. (2017). Reduced age-associated brain changes in expert meditators: a multimodal neuroimaging pilot study. Scientific reports, 7(1), 10160. https://doi.org/10.1038/s41598-017-07764-x
Chiesa, A. (2010). Vipassana meditation: systematic review of current evidence. The Journal of Alternative and Complementary Medicine, 16(1), 37–46. https://doi.org/10.1089/acm.2009.0362
doi: 10.1089/acm.2009.0362
pubmed: 20055558
Chiu, P. W., Mak, H. K., Yau, K. K., Chan, Q., Chang, R. C., & Chu, L. W. (2014). Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain: Proton magnetic resonance spectroscopy study at 3 T. Age (dordrecht, Netherlands), 36(1), 251–264. https://doi.org/10.1007/s11357-013-9545-8
doi: 10.1007/s11357-013-9545-8
Critchley, H. D., & Harrison, N. A. (2013). Visceral influences on brain and behavior. Neuron, 77(4), 624–638. https://doi.org/10.1016/j.neuron.2013.02.008
doi: 10.1016/j.neuron.2013.02.008
pubmed: 23439117
Cromheeke, S., & Mueller, S. C. (2014). Probing emotional influences on cognitive control: An ALE meta-analysis of cognition emotion interactions. Brain Structure & Function, 219(3), 995–1008. https://doi.org/10.1007/s00429-013-0549-z
doi: 10.1007/s00429-013-0549-z
Damasio, A. R. (1994). Descartes’ error : Emotion, reason, and the human brain. G.P. Putnam.
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995). Contributions of anterior cingulate cortex to behaviour. Brain, 118(Pt 1), 279–306. https://doi.org/10.1093/brain/118.1.279
doi: 10.1093/brain/118.1.279
pubmed: 7895011
Drevets, W. C., Savitz, J., & Trimble, M. (2008). The subgenual anterior cingulate cortex in mood disorders. CNS Spectrums, 13(8), 663–681. https://doi.org/10.1017/s1092852900013754
doi: 10.1017/s1092852900013754
pubmed: 18704022
pmcid: 2729429
Drobisz, D., & Damborska, A. (2019). Deep brain stimulation targets for treating depression. Behavioural Brain Research, 359, 266–273. https://doi.org/10.1016/j.bbr.2018.11.004
doi: 10.1016/j.bbr.2018.11.004
pubmed: 30414974
Eickhoff, S. B., Stephan, K. E., Mohlberg, H., Grefkes, C., Fink, G. R., Amunts, K., & Zilles, K. (2005). A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data. NeuroImage, 25(4), 1325–1335. https://doi.org/10.1016/j.neuroimage.2004.12.034
doi: 10.1016/j.neuroimage.2004.12.034
pubmed: 15850749
Etkin, A., Egner, T., & Kalisch, R. (2011). Emotional processing in anterior cingulate and medial prefrontal cortex. Trends in Cognitive Sciences, 15(2), 85–93. https://doi.org/10.1016/j.tics.2010.11.004
doi: 10.1016/j.tics.2010.11.004
pubmed: 21167765
Farrell, M. J., Laird, A. R., & Egan, G. F. (2005). Brain activity associated with painfully hot stimuli applied to the upper limb: A meta-analysis. Human Brain Mapping, 25(1), 129–139. https://doi.org/10.1002/hbm.20125
doi: 10.1002/hbm.20125
pubmed: 15846813
pmcid: 6871740
Fjell, A. M., Walhovd, K. B., Fennema-Notestine, C., McEvoy, L. K., Hagler, D. J., Holland, D., ..., Dale, A. M. (2009a). One-year brain atrophy evident in healthy aging. Journal of Neuroscience, 29(48), 15223-15231. https://doi.org/10.1523/JNEUROSCI.3252-09.2009
Fjell, A. M., Westlye, L. T., Amlien, I., Espeseth, T., Reinvang, I., Raz, N., ..., Walhovd, K. B. (2009b). High consistency of regional cortical thinning in aging across multiple samples. Cereb Cortex, 19(9), 2001-2012. https://doi.org/10.1093/cercor/bhn232
Fjell, A. M., Westlye, L. T., Grydeland, H., Amlien, I., Espeseth, T., Reinvang, I., ..., Alzheimer Disease Neuroimaging, I. (2014). Accelerating cortical thinning: unique to dementia or universal in aging? Cerebral Cortex, 24(4), 919-934. https://doi.org/10.1093/cercor/bhs379
Fox, K. C., Dixon, M. L., Nijeboer, S., Girn, M., Floman, J. L., Lifshitz, M., ..., Christoff, K. (2016). Functional neuroanatomy of meditation: A review and meta-analysis of 78 functional neuroimaging investigations. Neuroscience & Biobehavioral Reviews, 65, 208-228. https://doi.org/10.1016/j.neubiorev.2016.03.021
Freedman, L. J., Insel, T. R., & Smith, Y. (2000). Subcortical projections of area 25 (subgenual cortex) of the macaque monkey. The Journal of Comparative Neurology, 421(2), 172–188. https://doi.org/10.1002/(SICI)1096-9861(20000529)421:2%3C172::AID-CNE4%3E3.0.CO;2-8
doi: 10.1002/(SICI)1096-9861(20000529)421:2%3C172::AID-CNE4%3E3.0.CO;2-8
pubmed: 10813780
Gard, T., Holzel, B. K., & Lazar, S. W. (2014). The potential effects of meditation on age-related cognitive decline: A systematic review. Annals of the New York Academy of Sciences, 1307, 89–103. https://doi.org/10.1111/nyas.12348
doi: 10.1111/nyas.12348
pubmed: 24571182
pmcid: 4024457
Gianaros, P. J., Derbyshire, S. W., May, J. C., Siegle, G. J., Gamalo, M. A., & Jennings, J. R. (2005). Anterior cingulate activity correlates with blood pressure during stress. Psychophysiology, 42(6), 627–635. https://doi.org/10.1111/j.1469-8986.2005.00366.x
doi: 10.1111/j.1469-8986.2005.00366.x
pubmed: 16364058
pmcid: 2246096
Glaser, D., & Friston, K. (2007). Covariance Components. In K. Friston, J. Ashburner, S. Kiebel, T. E. Nichols, & W. D. Penny (Eds.), Statistical Parametric Mapping: The Analysis of Functional Brain Images (pp. 140–147). Elsevier.
doi: 10.1016/B978-012372560-8/50010-3
Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N., Friston, K. J., & Frackowiak, R. S. (2001). A voxel-based morphometric study of ageing in 465 normal adult human brains. NeuroImage, 14(1 Pt 1), 21–36. https://doi.org/10.1006/nimg.2001.0786
doi: 10.1006/nimg.2001.0786
pubmed: 11525331
Gotink, R. A., Meijboom, R., Vernooij, M. W., Smits, M., & Hunink, M. G. (2016). 8-week Mindfulness Based Stress Reduction induces brain changes similar to traditional long-term meditation practice - A systematic review. Brain and Cognition, 108, 32–41. https://doi.org/10.1016/j.bandc.2016.07.001
doi: 10.1016/j.bandc.2016.07.001
pubmed: 27429096
Hamani, C., Mayberg, H., Stone, S., Laxton, A., Haber, S., & Lozano, A. M. (2011). The subcallosal cingulate gyrus in the context of major depression. Biological Psychiatry, 69(4), 301–308. https://doi.org/10.1016/j.biopsych.2010.09.034
doi: 10.1016/j.biopsych.2010.09.034
pubmed: 21145043
Hochberg, Y., & Benjamini, Y. (1990). More powerful procedures for multiple significance testing. Statistics in Medicine, 9(7), 811–818. https://doi.org/10.1002/sim.4780090710
doi: 10.1002/sim.4780090710
pubmed: 2218183
James, W. (1894). Physical basis of emotion. Psychological Review, 1, 516–529.
doi: 10.1037/h0065078
Jindal, V., Gupta, S., & Das, R. (2013). Molecular mechanisms of meditation. Molecular Neurobiology, 48(3), 808–811. https://doi.org/10.1007/s12035-013-8468-9
doi: 10.1007/s12035-013-8468-9
pubmed: 23737355
Johansen-Berg, H., Gutman, D. A., Behrens, T. E., Matthews, P. M., Rushworth, M. F., Katz, E., ..., Mayberg, H. S. (2008). Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression. Cerebral Cortex, 18(6), 1374-1383. https://doi.org/10.1093/cercor/bhm167
Kimmerly, D. S., O’Leary, D. D., Menon, R. S., Gati, J. S., & Shoemaker, J. K. (2005). Cortical regions associated with autonomic cardiovascular regulation during lower body negative pressure in humans. Journal of Physiology, 569(Pt 1), 331–345. https://doi.org/10.1113/jphysiol.2005.091637
doi: 10.1113/jphysiol.2005.091637
Kurth, F., Cherbuin, N., & Luders, E. (2015a). Reduced age-related degeneration of the hippocampal subiculum in long-term meditators. Psychiatry Research, 232(3), 214–218. https://doi.org/10.1016/j.pscychresns.2015.03.008
doi: 10.1016/j.pscychresns.2015.03.008
pubmed: 25907419
Kurth, F., MacKenzie-Graham, A., Toga, A. W., & Luders, E. (2015b). Shifting brain asymmetry: The link between meditation and structural lateralization. Soc Cogn Affect Neurosci, 10(1), 55–61. https://doi.org/10.1093/scan/nsu029
doi: 10.1093/scan/nsu029
pubmed: 24643652
Kurth, F., Cherbuin, N., & Luders, E. (2017a). Aging mindfully to minimize cognitive decline. Journal of Cognitive Enhancement, 1(2), 108–114. https://doi.org/10.1007/s41465-017-0027-2
doi: 10.1007/s41465-017-0027-2
Kurth, F., Cherbuin, N., & Luders, E. (2017b). The impact of aging on subregions of the hippocampal complex in healthy adults. NeuroImage, 163, 296–300. https://doi.org/10.1016/j.neuroimage.2017.09.016
doi: 10.1016/j.neuroimage.2017.09.016
pubmed: 28917699
Kurth, F., Cherbuin, N., & Luders, E. (2017c). Promising Links between Meditation and Reduced (Brain) Aging: An Attempt to Bridge Some Gaps between the Alleged Fountain of Youth and the Youth of the Field. Frontiers in Psychology, 8, 860. https://doi.org/10.3389/fpsyg.2017.00860
doi: 10.3389/fpsyg.2017.00860
pubmed: 28611710
pmcid: 5447722
Kurth, F., Jancke, L., & Luders, E. (2017d). Sexual dimorphism of Broca’s region: More gray matter in female brains in Brodmann areas 44 and 45. Journal of Neuroscience Research, 95(1–2), 626–632. https://doi.org/10.1002/jnr.23898
doi: 10.1002/jnr.23898
pubmed: 27870461
pmcid: 5119534
Kurth, F., Jancke, L., & Luders, E. (2018). Integrating cytoarchitectonic tissue probabilities with MRI-based signal intensities to calculate volumes of interest. In G. Spalletta, T. Gili, & F. Piras (Eds.), Brain Morphometry: Methods and Clinical Applications (pp. 121–129). Springer.
Kurth, F., Cherbuin, N., & Luders, E. (2019). Age but no sex effects on subareas of the amygdala. Human Brain Mapping, 40(6), 1697–1704. https://doi.org/10.1002/hbm.24481
doi: 10.1002/hbm.24481
pubmed: 30549129
Laneri, D., Schuster, V., Dietsche, B., Jansen, A., Ott, U., & Sommer, J. (2016). Effects of Long-Term Mindfulness Meditation on Brain’s White Matter Microstructure and its Aging. Frontiers in Aging Neuroscience, 7, 254. https://doi.org/10.3389/fnagi.2015.00254
doi: 10.3389/fnagi.2015.00254
pubmed: 26834624
pmcid: 4712309
Lange, C. G. (1885). The mechanism of the emotion. In B. Rand (Ed.), The classical psychologist (pp. 672–685). Houghton Mifflin.
Lazar, S. W., Kerr, C. E., Wasserman, R. H., Gray, J. R., Greve, D. N., Treadway, M. T., ..., Fischl, B. (2005). Meditation experience is associated with increased cortical thickness. Neuroreport, 16(17), 1893–1897. Retrieved from PM:16272874
Lockwood, P. L., & Wittmann, M. K. (2018). Ventral anterior cingulate cortex and social decision-making. Neuroscience and Biobehavioral Reviews, 92, 187–191. https://doi.org/10.1016/j.neubiorev.2018.05.030
doi: 10.1016/j.neubiorev.2018.05.030
pubmed: 29886177
pmcid: 7611523
Luders, E., & Cherbuin, N. (2016). Searching for the philosopher’s stone: Promising links between meditation and brain preservation. Annals of the New York Academy of Sciences, 1373(1), 38–44. https://doi.org/10.1111/nyas.13082
doi: 10.1111/nyas.13082
pubmed: 27187107
Luders, E., Toga, A. W., Lepore, N., & Gaser, C. (2009). The underlying anatomical correlates of long-term meditation: Larger hippocampal and frontal volumes of gray matter. NeuroImage, 45(3), 672–678. https://doi.org/10.1016/j.neuroimage.2008.12.061
doi: 10.1016/j.neuroimage.2008.12.061
pubmed: 19280691
Luders, E., Clark, K., Narr, K. L., & Toga, A. W. (2011). Enhanced brain connectivity in long-term meditation practitioners. NeuroImage, 57(4), 1308–1316. https://doi.org/10.1016/j.neuroimage.2011.05.075
doi: 10.1016/j.neuroimage.2011.05.075
pubmed: 21664467
Luders, E., Kurth, F., Mayer, E. A., Toga, A. W., Narr, K. L., & Gaser, C. (2012a). The unique brain anatomy of meditation practitioners: Alterations in cortical gyrification. Frontiers in Human Neuroscience, 6, 34. https://doi.org/10.3389/fnhum.2012.00034
doi: 10.3389/fnhum.2012.00034
pubmed: 22393318
pmcid: 3289949
Luders, E., Phillips, O. R., Clark, K., Kurth, F., Toga, A. W., & Narr, K. L. (2012b). Bridging the hemispheres in meditation: Thicker callosal regions and enhanced fractional anisotropy (FA) in long-term practitioners. Neuroimage, 61(1), 181–187. Retrieved from PM:22374478
Luders, E., Kurth, F., Toga, A. W., Narr, K. L., & Gaser, C. (2013a). Meditation effects within the hippocampal complex revealed by voxel-based morphometry and cytoarchitectonic probabilistic mapping. Frontiers in Psychology, 4, 398. https://doi.org/10.3389/fpsyg.2013.00398
doi: 10.3389/fpsyg.2013.00398
pubmed: 23847572
pmcid: 3705194
Luders, E., Thompson, P. M., Kurth, F., Hong, J. Y., Phillips, O. R., Wang, Y., ..., Toga, A. W. (2013b). Global and regional alterations of hippocampal anatomy in long-term meditation practitioners. Human Brain Mapping, 34(12), 3369-3375. https://doi.org/10.1002/hbm.22153
Luders, E., Cherbuin, N., & Kurth, F. (2015). Forever Young(er): Potential Age-defying Effects of Long-term Meditation on Gray Matter Atrophy. Frontiers in Psychology, 5, 1551. https://doi.org/10.3389/fpsyg.2014.01551
doi: 10.3389/fpsyg.2014.01551
pubmed: 25653628
pmcid: 4300906
Luders, E., Cherbuin, N., & Gaser, C. (2016). Estimating brain age using high-resolution pattern recognition: Younger brains in long-term meditation practitioners. NeuroImage, 134, 508–513. https://doi.org/10.1016/j.neuroimage.2016.04.007
doi: 10.1016/j.neuroimage.2016.04.007
pubmed: 27079530
Marciniak, R., Sheardova, K., Cermakova, P., Hudecek, D., Sumec, R., & Hort, J. (2014). Effect of meditation on cognitive functions in context of aging and neurodegenerative diseases. Frontiers in Behavioral Neuroscience, 8, 17. https://doi.org/10.3389/fnbeh.2014.00017
doi: 10.3389/fnbeh.2014.00017
pubmed: 24478663
pmcid: 3903052
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., ..., Fox, P. T. (1999). Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. American Journal of Psychiatry, 156(5), 675-682. https://doi.org/10.1176/ajp.156.5.675
Mechias, M. L., Etkin, A., & Kalisch, R. (2010). A meta-analysis of instructed fear studies: Implications for conscious appraisal of threat. NeuroImage, 49(2), 1760–1768. https://doi.org/10.1016/j.neuroimage.2009.09.040
doi: 10.1016/j.neuroimage.2009.09.040
pubmed: 19786103
Pagnoni, G., & Cekic, M. (2007). Age effects on gray matter volume and attentional performance in Zen meditation. Neurobiology of Aging, 28(10), 1623–1627. https://doi.org/10.1016/j.neurobiolaging.2007.06.008
doi: 10.1016/j.neurobiolaging.2007.06.008
pubmed: 17655980
Palomero-Gallagher, N., Mohlberg, H., Zilles, K., & Vogt, B. (2008). Cytology and receptor architecture of human anterior cingulate cortex. The Journal of Comparative Neurology, 508(6), 906–926. https://doi.org/10.1002/cne.21684
doi: 10.1002/cne.21684
pubmed: 18404667
pmcid: 2678551
Palomero-Gallagher, N., Eickhoff, S. B., Hoffstaedter, F., Schleicher, A., Mohlberg, H., Vogt, B. A., ..., Zilles, K. (2015). Functional organization of human subgenual cortical areas: relationship between architectonical segregation and connectional heterogeneity. Neuroimage, 115, 177-190. https://doi.org/10.1016/j.neuroimage.2015.04.053
Pardo, J. V., Lee, J. T., Sheikh, S. A., Surerus-Johnson, C., Shah, H., Munch, K. R., ..., Dysken, M. W. (2007). Where the brain grows old: decline in anterior cingulate and medial prefrontal function with normal aging. Neuroimage, 35(3), 1231-1237. https://doi.org/10.1016/j.neuroimage.2006.12.044
Resnick, S. M., Pham, D. L., Kraut, M. A., Zonderman, A. B., & Davatzikos, C. (2003). Longitudinal magnetic resonance imaging studies of older adults: A shrinking brain. Journal of Neuroscience, 23(8), 3295–3301. https://doi.org/10.1523/JNEUROSCI.23-08-03295.2003
doi: 10.1523/JNEUROSCI.23-08-03295.2003
pubmed: 12716936
Rosenkranz, M. A., Lutz, A., Perlman, D. M., Bachhuber, D. R., Schuyler, B. S., MacCoon, D. G., & Davidson, R. J. (2016). Reduced stress and inflammatory responsiveness in experienced meditators compared to a matched healthy control group. Psychoneuroendocrinology, 68, 117–125. https://doi.org/10.1016/j.psyneuen.2016.02.013
doi: 10.1016/j.psyneuen.2016.02.013
pubmed: 26970711
pmcid: 4851883
Rudebeck, P. H., Putnam, P. T., Daniels, T. E., Yang, T., Mitz, A. R., Rhodes, S. E., & Murray, E. A. (2014). A role for primate subgenual cingulate cortex in sustaining autonomic arousal. Proc Natl Acad Sci U S A, 111(14), 5391–5396. https://doi.org/10.1073/pnas.1317695111
doi: 10.1073/pnas.1317695111
pubmed: 24706828
pmcid: 3986148
Scharnowski, F., Nicholson, A. A., Pichon, S., Rosa, M. J., Rey, G., Eickhoff, S. B., ..., Koush, Y. (2020). The role of the subgenual anterior cingulate cortex in dorsomedial prefrontal-amygdala neural circuitry during positive-social emotion regulation. Human Brain Mapping, 41(11), 3100-3118. https://doi.org/10.1002/hbm.25001
Smith, R., Ahern, G. L., & Lane, R. D. (2019). The role of anterior and midcingulate cortex in emotional awareness: A domain-general processing perspective. Handbook of Clinical Neurology, 166, 89–101. https://doi.org/10.1016/B978-0-444-64196-0.00006-6
doi: 10.1016/B978-0-444-64196-0.00006-6
pubmed: 31731927
Sowell, E. R., Peterson, B. S., Thompson, P. M., Welcome, S. E., Henkenius, A. L., & Toga, A. W. (2003). Mapping cortical change across the human life span. Nature Neuroscience, 6(3), 309–315. https://doi.org/10.1038/nn1008
doi: 10.1038/nn1008
pubmed: 12548289
Touroutoglou, A., & Dickerson, B. C. (2019). Cingulate-centered large-scale networks: Normal functions, aging, and neurodegenerative disease. Handbook of Clinical Neurology, 166, 113–127. https://doi.org/10.1016/B978-0-444-64196-0.00008-X
doi: 10.1016/B978-0-444-64196-0.00008-X
pubmed: 31731908
Vogt, B. A. (2015). Mapping cingulate subregions. In A. W. Toga (Ed.), Brain Mapping: An Encyclopedic Reference (Vol. 2, pp. 325–339). Academic Press.
doi: 10.1016/B978-0-12-397025-1.00230-X
Vogt, B. A., & Pandya, D. N. (1987). Cingulate cortex of the rhesus monkey: II Cortical Afferents. The Journal of Comparative Neurology, 262(2), 271–289. https://doi.org/10.1002/cne.902620208
doi: 10.1002/cne.902620208
pubmed: 3624555
Wong, S. W., Masse, N., Kimmerly, D. S., Menon, R. S., & Shoemaker, J. K. (2007). Ventral medial prefrontal cortex and cardiovagal control in conscious humans. NeuroImage, 35(2), 698–708. https://doi.org/10.1016/j.neuroimage.2006.12.027
doi: 10.1016/j.neuroimage.2006.12.027
pubmed: 17291781
Ziegler, G., Dahnke, R., Jancke, L., Yotter, R. A., May, A., & Gaser, C. (2012). Brain structural trajectories over the adult lifespan. Human Brain Mapping, 33(10), 2377–2389. https://doi.org/10.1002/hbm.21374
doi: 10.1002/hbm.21374
pubmed: 21898677
Zsadanyi, S. E., Kurth, F., & Luders, E. (2021). The Effects of Mindfulness and Meditation on the Cingulate Cortex in the Healthy Human Brain: A Review. Mindfulness. https://doi.org/10.1007/s12671-021-01712-7
doi: 10.1007/s12671-021-01712-7