Bacterial vaginosis and other infections in pregnant women in Senegal.
Bacterial vaginosis
Pregnant women
Vaginal microbiome
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
23 Oct 2021
23 Oct 2021
Historique:
received:
26
10
2020
accepted:
04
10
2021
entrez:
24
10
2021
pubmed:
25
10
2021
medline:
27
10
2021
Statut:
epublish
Résumé
Bacterial vaginosis (BV) is associated with a higher risk of preterm delivery and spontaneous abortion. Yet little data on BV prevalence exist for sub-Saharan countries. The aim of this study was to estimate the prevalence of bacterial vaginosis and associated risk factors among pregnant women in Senegal. From October 2013 to December 2018, pregnant women in their third trimester were recruited in two primary health centers (one suburban, one rural) in Senegal. Healthcare workers interviewed women and collected a lower vaginal swab and a blood sample. Vaginal flora were classified into four categories using vaginal smear microscopic examination and Gram's coloration. In our study, BV was defined as vaginal flora with no Lactobacillus spp. Variables associated with BV were analyzed using STATA® through univariate and multivariate analysis. A total of 457 women provided a vaginal sample for analysis. Overall, BV prevalence was 18.6% (85/457) [95% CI 15.4-22.6]) and was similar in suburban and rural areas (18.9% versus 18.1%, p = 0.843). Multivariate analysis showed that primigravidity was the only factor independently associated with a lower risk of BV (aOR 0.35 [95% CI 0.17-0.72]). Our study showed significant BV prevalence among pregnant women in Senegal. Although the literature has underscored the potential consequences of BV for obstetric outcomes, data are scarce on BV prevalence in sub-Saharan African countries. Before authorities consider systematic BV screening for pregnant women, a larger study would be useful in documenting prevalence, risk factors and the impact of BV on pregnancy outcomes.
Sections du résumé
BACKGROUND
BACKGROUND
Bacterial vaginosis (BV) is associated with a higher risk of preterm delivery and spontaneous abortion. Yet little data on BV prevalence exist for sub-Saharan countries. The aim of this study was to estimate the prevalence of bacterial vaginosis and associated risk factors among pregnant women in Senegal.
METHODS
METHODS
From October 2013 to December 2018, pregnant women in their third trimester were recruited in two primary health centers (one suburban, one rural) in Senegal. Healthcare workers interviewed women and collected a lower vaginal swab and a blood sample. Vaginal flora were classified into four categories using vaginal smear microscopic examination and Gram's coloration. In our study, BV was defined as vaginal flora with no Lactobacillus spp. Variables associated with BV were analyzed using STATA® through univariate and multivariate analysis.
RESULTS
RESULTS
A total of 457 women provided a vaginal sample for analysis. Overall, BV prevalence was 18.6% (85/457) [95% CI 15.4-22.6]) and was similar in suburban and rural areas (18.9% versus 18.1%, p = 0.843). Multivariate analysis showed that primigravidity was the only factor independently associated with a lower risk of BV (aOR 0.35 [95% CI 0.17-0.72]).
CONCLUSIONS
CONCLUSIONS
Our study showed significant BV prevalence among pregnant women in Senegal. Although the literature has underscored the potential consequences of BV for obstetric outcomes, data are scarce on BV prevalence in sub-Saharan African countries. Before authorities consider systematic BV screening for pregnant women, a larger study would be useful in documenting prevalence, risk factors and the impact of BV on pregnancy outcomes.
Identifiants
pubmed: 34688270
doi: 10.1186/s12879-021-06767-4
pii: 10.1186/s12879-021-06767-4
pmc: PMC8542293
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1090Informations de copyright
© 2021. The Author(s).
Références
BMC Infect Dis. 2015 Jul 29;15:292
pubmed: 26219949
Front Cell Infect Microbiol. 2020 Nov 05;10:540900
pubmed: 33251154
BMC Infect Dis. 2020 Aug 26;20(1):629
pubmed: 32842982
Sante. 1996 Mar-Apr;6(2):102-6
pubmed: 8705118
Infect Immun. 2012 Nov;80(11):3975-84
pubmed: 22949550
J Obstet Gynaecol Res. 2004 Jun;30(3):230-6
pubmed: 15210049
PLoS Med. 2018 Feb 27;15(2):e1002511
pubmed: 29485986
Clin Microbiol Infect. 2019 Jan;25(1):35-47
pubmed: 29729331
BMC Res Notes. 2014 Nov 20;7:822
pubmed: 25409756
Am J Obstet Gynecol. 1992 Mar;166(3):938-44
pubmed: 1372474
PLoS Med. 2012;9(6):e1001251
pubmed: 22745608
J Gynecol Obstet Hum Reprod. 2020 Sep;49(7):101814
pubmed: 32428782
Emerg Infect Dis. 2018 Apr;24(4):710-717
pubmed: 29553312
J Infect Dis. 2015 Jul 1;212(1):8-17
pubmed: 25589333
Eur J Obstet Gynecol Reprod Biol. 2013 Jun;168(2):222-6
pubmed: 23395560
Clin Ther. 2016 Dec;38(12):2567-2577
pubmed: 27836494
Clin Infect Dis. 2008 Dec 1;47(11):1426-35
pubmed: 18947329
J Clin Microbiol. 1991 Feb;29(2):297-301
pubmed: 1706728
Sex Transm Infect. 2004 Feb;80(1):58-62
pubmed: 14755039
Am J Trop Med Hyg. 2014 Jun;90(6):1135-9
pubmed: 24710615
Am J Obstet Gynecol. 2003 Jul;189(1):139-47
pubmed: 12861153
J Parasit Dis. 2016 Sep;40(3):569-79
pubmed: 27605750
APMIS. 2015 Apr;123(4):321-5
pubmed: 25628065
PLoS One. 2017 Nov 6;12(11):e0187654
pubmed: 29108022
Clin Infect Dis. 2003 Mar 1;36(5):663-8
pubmed: 12594649
Parasitol Res. 2011 Nov;109(5):1447-52
pubmed: 21541753
J Infect Dis. 1999 Dec;180(6):1863-8
pubmed: 10558942
Appl Environ Microbiol. 2014 Apr;80(7):2176-85
pubmed: 24487536
Infect Dis (Auckl). 2019 May 31;12:1178633719851825
pubmed: 31210732
J Infect Dis. 2017 Sep 15;216(6):744-751
pubmed: 28934437
J Infect Dis. 2005 Oct 15;192(8):1372-80
pubmed: 16170754
N Engl J Med. 1995 Dec 28;333(26):1737-42
pubmed: 7491137
BMC Infect Dis. 2019 Dec 16;19(1):1056
pubmed: 31842783
Microbiome. 2016 Nov 1;4(1):58
pubmed: 27802830
Matern Child Health J. 2018 Jun;22(6):812-821
pubmed: 29417367
JAMA. 2020 Apr 7;323(13):1286-1292
pubmed: 32259236