Ketone bodies: back to a place in the sun.

Diabetic Ketoacidosis Humans Ketone Bodies Longevity Oxidative Stress

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
11 2021
Historique:
received: 08 07 2021
revised: 09 07 2021
accepted: 14 07 2021
entrez: 24 10 2021
pubmed: 25 10 2021
medline: 3 11 2021
Statut: ppublish

Résumé

Ketone bodies have a strong negative image in medicine because of ketoacidosis, a life-threatening complication in diabetes. However, Fang et al. report that ketone bodies exert antisenescent effects in podocytes under diabetic conditions, via activation of the nuclear factor E2-related factor 2-related antioxidative stress pathway. With recent progression of research on longevity, the beneficial effects of ketone bodies are being clarified, and a positive image of ketone bodies is gradually beginning to develop in many research fields including nephrology.

Identifiants

DOI: 10.1016/j.kint.2021.07.022 PMID: 34688385
pubmed: 34688385
pii: S0085-2538(21)00742-0
doi: 10.1016/j.kint.2021.07.022
pii:
doi:

Substances chimiques

Ketone Bodies 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

976-978

Informations de copyright

Copyright © 2021 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Auteurs

Shinji Kume (S)

Department of Medicine, Shiga University of Medical Science, Shiga, Japan. Electronic address: skume@belle.shiga-med.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Maladies endocriniennes › Diabète › Complications du diabète › Acidocétose diabétique › Ketone bodies: back to a place in the sun.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ketone bodies: back to a place in the sun.
questionsmedicales.fr › Composés chimiques organiques › Cétones › Corps cétoniques › Ketone bodies: back to a place in the sun.
questionsmedicales.fr › Phénomènes physiologiques › Longévité › Ketone bodies: back to a place in the sun.
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Ketone bodies: back to a place in the sun.