Grandiflorenic acid isolated from Sphagneticola trilobata against Trypanosoma cruzi: Toxicity, mechanisms of action and immunomodulation.
Animals
Antiprotozoal Agents
/ pharmacology
Asteraceae
/ chemistry
Cell Line
Chagas Disease
/ drug therapy
Diterpenes
/ pharmacology
Humans
Immunomodulation
/ drug effects
Macaca mulatta
Macrophages
/ parasitology
Mice
Reactive Oxygen Species
/ metabolism
Trypanosoma cruzi
/ drug effects
Tumor Necrosis Factor-alpha
/ metabolism
Apoptosis
Kaurane diterpene
ROS
TNF-α
Tripanocidal activity
Wedelia paludosa
Journal
Toxicology in vitro : an international journal published in association with BIBRA
ISSN: 1879-3177
Titre abrégé: Toxicol In Vitro
Pays: England
ID NLM: 8712158
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
11
08
2021
revised:
15
10
2021
accepted:
18
10
2021
pubmed:
25
10
2021
medline:
10
2
2022
entrez:
24
10
2021
Statut:
ppublish
Résumé
Grandiflorenic acid (GFA) is one of the main kaurane diterpenes found in different parts of Sphagneticola trilobata. It has several biological activities, especially antiprotozoal action. In turn, Chagas disease is a complex systemic disease caused by the protozoan Trypanosoma cruzi, and the drugs available to treat it involve significant side effects and impose an urgent need to search for therapeutic alternatives. In this context, our goal was to determine the effect of GFA on trypomastigote and intracellular amastigote forms. Our results showed that GFA treatment led to significantly less viability of trypomastigote forms, with morphological and ultrastructural changes in the parasites treated with IC
Identifiants
pubmed: 34688839
pii: S0887-2333(21)00192-2
doi: 10.1016/j.tiv.2021.105267
pii:
doi:
Substances chimiques
Antiprotozoal Agents
0
Diterpenes
0
Reactive Oxygen Species
0
Tumor Necrosis Factor-alpha
0
grandiflorenic acid
22338-67-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105267Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.