Distribution of seven ApoC-III glycoforms in plasma, VLDL, IDL, LDL and HDL of healthy subjects.
Apolipoprotein C-III
Cardiovascular disease
Lipoproteins
Type 2 diabetes
Journal
Journal of proteomics
ISSN: 1876-7737
Titre abrégé: J Proteomics
Pays: Netherlands
ID NLM: 101475056
Informations de publication
Date de publication:
16 01 2022
16 01 2022
Historique:
received:
26
07
2021
revised:
15
09
2021
accepted:
06
10
2021
pubmed:
25
10
2021
medline:
26
2
2022
entrez:
24
10
2021
Statut:
ppublish
Résumé
Glycosylation of ApoC-III modulates its function in TG metabolism, with some variants being associated with a more atherogenic lipid profile. These associations have been studied in whole plasma but rarely in individual lipoprotein fractions. In this study, we aimed to measure the relative content of ApoC-III glycoforms in each lipoprotein fraction as a potential biomarker for TG metabolism and cardiovascular risk. Lipoprotein fractions were separated by differential ultracentrifugation of plasma samples from healthy subjects. Relative concentrations of seven ApoC-III variants were measured by MSIA. ApoC-III
Identifiants
pubmed: 34688878
pii: S1874-3919(21)00297-9
doi: 10.1016/j.jprot.2021.104398
pii:
doi:
Substances chimiques
Apolipoprotein C-III
0
Lipoproteins
0
Lipoproteins, LDL
0
Lipoproteins, VLDL
0
Triglycerides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104398Informations de copyright
Copyright © 2021. Published by Elsevier B.V.