Complement multiplex testing: Concept, promises and pitfalls.
C1-INH
C1q
C3
C4
Complement
Diagnostics
Multiplex
Journal
Molecular immunology
ISSN: 1872-9142
Titre abrégé: Mol Immunol
Pays: England
ID NLM: 7905289
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
22
05
2021
revised:
15
08
2021
accepted:
06
10
2021
pubmed:
25
10
2021
medline:
24
12
2021
entrez:
24
10
2021
Statut:
ppublish
Résumé
Complement is a complex system. This complexity becomes more obvious when looking at complement analysis in health and disease, where one presentation can require a number of measurements to understand the full role of this cascade in the disease. The current state of clinical testing requires multiple tests to cover the whole of the complement cascade. There is a clear potential for multiplex testing to help address this need for comprehensive analysis of the state of complement deficiency, activation or inhibition. Fortunately, there are a number of potential methods for multiplex analysis, each with advantages and disadvantages that need to be considered in light of the intricacy of the complement cascade and its interconnection to other systems. Despite the complexities of such methods several groups have started utilizing multiplex analysis for research and even for diagnostic testing. The potential methods, current successes, and the type of testing that needs to be streamlined are reviewed in this text.
Identifiants
pubmed: 34688958
pii: S0161-5890(21)00296-0
doi: 10.1016/j.molimm.2021.10.006
pii:
doi:
Substances chimiques
Complement System Proteins
9007-36-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
120-126Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.