Genome-wide Gene-by-Sex Interaction Studies Identify Novel Nonsyndromic Orofacial Clefts Risk Locus.
bioinformatics
craniofacial anomalies
craniofacial biology/genetics
developmental biology
gender differences
gene expression
Journal
Journal of dental research
ISSN: 1544-0591
Titre abrégé: J Dent Res
Pays: United States
ID NLM: 0354343
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
pubmed:
26
10
2021
medline:
5
4
2022
entrez:
25
10
2021
Statut:
ppublish
Résumé
Risk loci identified through genome-wide association studies have explained about 25% of the phenotypic variations in nonsyndromic orofacial clefts (nsOFCs) on the liability scale. Despite the notable sex differences in the incidences of the different cleft types, investigation of loci for sex-specific effects has been understudied. To explore the sex-specific effects in genetic etiology of nsOFCs, we conducted a genome-wide gene × sex (GxSex) interaction study in a sub-Saharan African orofacial cleft cohort. The sample included 1,019 nonsyndromic orofacial cleft cases (814 cleft lip with or without cleft palate and 205 cleft palate only) and 2,159 controls recruited from 3 sites (Ethiopia, Ghana, and Nigeria). An additive logistic model was used to examine the joint effects of the genotype and GxSex interaction. Furthermore, we examined loci with suggestive significance (
Identifiants
pubmed: 34689653
doi: 10.1177/00220345211046614
pmc: PMC8935575
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
465-472Subventions
Organisme : NIDCR NIH HHS
ID : R90 DE024296
Pays : United States
Organisme : NIDCR NIH HHS
ID : K99 DE022378
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE028300
Pays : United States
Organisme : NIDCR NIH HHS
ID : R03 DE024776
Pays : United States
Organisme : NIDCR NIH HHS
ID : R00 DE022378
Pays : United States
Organisme : NIDCR NIH HHS
ID : K43 DE029427
Pays : United States
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