RdRp (RNA-dependent RNA polymerase): A key target providing anti-virals for the management of various viral diseases.
BVDV
Covid 19
Dengue
HCV (Hepatitis)
Influenza
RdRp
RdRp inhibitors
Journal
Journal of molecular structure
ISSN: 0022-2860
Titre abrégé: J Mol Struct
Pays: Netherlands
ID NLM: 0141747
Informations de publication
Date de publication:
15 Feb 2022
15 Feb 2022
Historique:
received:
30
07
2021
revised:
13
10
2021
accepted:
15
10
2021
entrez:
25
10
2021
pubmed:
26
10
2021
medline:
26
10
2021
Statut:
ppublish
Résumé
With the arrival of the Covid-19 pandemic, anti-viral agents have regained center stage in the arena of medicine. Out of the various drug targets involved in managing RNA-viral infections, the one that dominates almost all RNA viruses is RdRp (RNA-dependent RNA polymerase). RdRp are proteins that are involved in the replication of RNA-based viruses. Inhibition of RdRps has been an integral approach for managing various viral infections such as dengue, influenza, HCV (Hepatitis), BVDV, etc. Inhibition of the coronavirus RdRp is currently rigorously explored for the treatment of Covid-19 related complications. So, keeping in view the importance and current relevance of this drug target, we have discussed the importance of RdRp in developing anti-viral agents against various viral diseases. Different reported inhibitors have also been discussed, and emphasis has been laid on highlighting the inhibitor's pharmacophoric features and SAR profile.
Identifiants
pubmed: 34690363
doi: 10.1016/j.molstruc.2021.131756
pii: S0022-2860(21)01881-0
pmc: PMC8520695
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
131756Informations de copyright
© 2021 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Authors declare no conflict of interest. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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