Connectomics in Brain Aging and Dementia - The Background and Design of a Study of a Connectome Related to Human Disease.
Connectome Related to Human Disease
MRI
aging
amyloid PET imaging
magnetoencepalography
neuropsychology
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
02
2021
accepted:
06
09
2021
entrez:
25
10
2021
pubmed:
26
10
2021
medline:
26
10
2021
Statut:
epublish
Résumé
The natural history of Alzheimer's Disease (AD) includes significant alterations in the human connectome, and this disconnection results in the dementia of AD. The organizing principle of our research project is the idea that the expression of cognitive dysfunction in the elderly is the result of two independent processes - the neuropathology associated with AD, and second the neuropathological changes of cerebrovascular disease. Synaptic loss, senile plaques, and neurofibrillary tangles are the functional and diagnostic hallmarks of AD, but it is the structural changes as a consequence of vascular disease that reduce brain reserve and compensation, resulting in an earlier expression of the clinical dementia syndrome. This work is being completed under the auspices of the Human Connectome Project (HCP). We have achieved an equal representation of Black individuals (vs. White individuals) and enrolled 60% Women. Each of the participants contributes demographic, behavioral and laboratory data. We acquire data relative to vascular risk, and the participants also undergo
Identifiants
pubmed: 34690734
doi: 10.3389/fnagi.2021.669490
pmc: PMC8530182
doi:
Types de publication
Journal Article
Langues
eng
Pagination
669490Subventions
Organisme : NIA NIH HHS
ID : P30 AG066468
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005133
Pays : United States
Informations de copyright
Copyright © 2021 Cohen, Bruña, Chang, Cheng, Doman, Huppert, Kim, Maestu, Roush, Snitz and Becker.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Am Geriatr Soc. 2005 Apr;53(4):649-54
pubmed: 15817012
Nat Rev Neurosci. 2011 Nov 03;12(12):723-38
pubmed: 22048062
Radiology. 2014 Oct;273(1):175-84
pubmed: 24865310
Ethn Health. 2014;19(5):479-99
pubmed: 24134165
Neuroimage. 2013 May 1;71:207-15
pubmed: 23353602
Neurology. 2016 Aug 2;87(5):539-47
pubmed: 27371494
JAMA Netw Open. 2020 Jun 1;3(6):e207559
pubmed: 32525547
Arterioscler Thromb Vasc Biol. 1997 Jun;17(6):1121-7
pubmed: 9194763
Neuroimage. 2019 Jan 15;185:335-348
pubmed: 30332613
Nat Genet. 2013 Dec;45(12):1452-8
pubmed: 24162737
J Am Geriatr Soc. 2013 Jan;61(1):158-9
pubmed: 23311557
Phys Med Biol. 2006 Apr 7;51(7):1759-68
pubmed: 16552102
Ann Neurol. 2009 May;65(5):557-68
pubmed: 19475670
Clin Neuropsychol. 2000 Nov;14(4):526-34
pubmed: 11262721
Annu Rev Public Health. 2011;32:381-98
pubmed: 21091195
Arch Neurol. 2004 Jan;61(1):67-72
pubmed: 14732622
Neurobiol Aging. 2020 Jan;85:58-73
pubmed: 31739167
Science. 2002 Oct 25;298(5594):789-91
pubmed: 12399581
Nucl Med Biol. 2000 Aug;27(6):529-32
pubmed: 11056365
Arch Neurol. 1991 Mar;48(3):278-81
pubmed: 2001185
Neurosci Bull. 2014 Apr;30(2):217-32
pubmed: 24733652
Neurology. 2007 Oct 30;69(18):1789-99
pubmed: 17914061
IEEE Trans Biomed Eng. 1997 Sep;44(9):867-80
pubmed: 9282479
J Health Polit Policy Law. 1986 Spring;11(1):97-116
pubmed: 3722786
Circulation. 2011 Mar 1;123(8):850-7
pubmed: 21321154
Comput Intell Neurosci. 2011;2011:156869
pubmed: 21253357
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Neurology. 2010 Oct 19;75(16):1415-22
pubmed: 20944075
Philos Trans R Soc Lond B Biol Sci. 2016 Aug 5;371(1700):
pubmed: 27377723
Lancet. 2017 Apr 8;389(10077):1453-1463
pubmed: 28402827
Public Health Rep. 2018 May/Jun;133(3):240-249
pubmed: 29614234
JAMA. 2003 Mar 19;289(11):1405-13
pubmed: 12636463
Neuropsychol Rev. 1994 Sep;4(3):161-98
pubmed: 7881456
JAMA Neurol. 2020 Sep 1;77(9):1063-1064
pubmed: 32539100
Matern Child Health J. 2014 Jul;18(5):1095-103
pubmed: 24026397
Neuroimage. 2013 Oct 15;80:105-24
pubmed: 23668970
Hum Brain Mapp. 2015 Jun;36(6):2248-69
pubmed: 25727740
Sci Rep. 2017 Jul 26;7(1):6517
pubmed: 28747760
Prog Mol Biol Transl Sci. 2019;165:25-61
pubmed: 31481165
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
Neurology. 2000 Dec 26;55(12):1863-9
pubmed: 11134386
J Int Neuropsychol Soc. 2005 Jan;11(1):108-16
pubmed: 15686613
Sensors (Basel). 2017 Dec 16;17(12):
pubmed: 29258189
Aging (Albany NY). 2011 Jan;3(1):63-76
pubmed: 21258136
Am J Public Health. 2015 Jul;105 Suppl 3:S374-6
pubmed: 25905830
Phys Med Biol. 2003 Nov 21;48(22):3637-52
pubmed: 14680264
Front Hum Neurosci. 2019 Feb 05;13:17
pubmed: 30792632
Alzheimers Dement. 2015 Nov;11(11):1377-84
pubmed: 25684687
Am J Hypertens. 2010 Feb;23(2):161-7
pubmed: 19927131
Genome Res. 2004 Sep;14(9):1679-85
pubmed: 15342553
Neuroscience. 2014 Jul 25;273:199-209
pubmed: 24836855
Am J Prev Med. 2011 Jan;40(1 Suppl 1):S4-18
pubmed: 21146778
Prog Neurobiol. 2011 Dec;95(4):535-46
pubmed: 21718750
J Magn Reson Imaging. 2015 Jan;41(1):102-9
pubmed: 24382798
Alzheimers Dement. 2017 Mar;13(3):205-216
pubmed: 27697430
J Aging Health. 2009 Aug;21(5):677-98
pubmed: 19584411
J Cereb Blood Flow Metab. 2005 Nov;25(11):1528-47
pubmed: 15944649
JAMA. 2009 Jun 3;301(21):2252-9
pubmed: 19491187
Neurology. 1994 Apr;44(4):609-14
pubmed: 8164812
Ethn Dis. 2015 Aug 07;25(3):245-54
pubmed: 26675362
Am J Public Health. 2000 Aug;90(8):1212-5
pubmed: 10936998
Stroke. 2008 Jul;39(7):1952-9
pubmed: 18436879
Matern Child Health J. 2009 Jan;13(1):29-39
pubmed: 18463971