Nonspecific Regulation of the Number of Immunocompetent Cells Under the Influence of DT Toxoid in Children With Glomerulonephritis.
Adolescent
Age Factors
Antibodies, Bacterial
/ blood
Case-Control Studies
Child
Child, Preschool
Comorbidity
Female
Glomerulonephritis
/ immunology
Humans
Immunity
Immunization, Secondary
Immunoglobulin G
/ immunology
Immunomodulation
Lymphocyte Count
Male
T-Lymphocytes
/ immunology
Tetanus Toxoid
/ administration & dosage
Vaccination
T-Lymphocytes
diphtheria and tetanus toxoid
glomerulonephritis
post-vaccination antibodies
vaccination in children
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
05
2021
accepted:
17
09
2021
entrez:
25
10
2021
pubmed:
26
10
2021
medline:
21
12
2021
Statut:
epublish
Résumé
Studies aimed at identifying the mechanisms of the immunoregulatory effect of vaccination with diphtheria and tetanus toxoid on the parameters of adaptive immunity in children with kidney pathology are limited. The study aimed to study the effect of revaccination against diphtheria and tetanus on the proliferation and differentiation of immunocompetent cells, the formation of specific antibodies, and the course of the disease in children with glomerulonephritis (GN). The study included 45 children with glomerulonephritis (GN) aged 5 to 15 years, in remission from 6 months up to 4 years. Of these, 25 children were revaccinated with DT toxoid (Diphtheria-Tetanus toxoid with reduced antigenic content) and 20 were in the control group (not vaccinated). The frequency of development of local and systemic reactions and the course of GN were assessed. The subpopulation structure of lymphocytes was studied in dynamics after 1-6-12 months by flow cytometry and IgG levels to diphtheria and tetanus were studied by ELISA. In 92% of children with GN, the post-vaccination period was uneventful. 8% showed a rise in temperature up to 37.3 Revaccination with DT toxoid in children with GN not only does not cause undesirable changes in the system of immunocompetent cells but also has an immunomodulatory effect, which contributes to the favorable maintenance of the remission period of the disease.
Sections du résumé
Background
Studies aimed at identifying the mechanisms of the immunoregulatory effect of vaccination with diphtheria and tetanus toxoid on the parameters of adaptive immunity in children with kidney pathology are limited. The study aimed to study the effect of revaccination against diphtheria and tetanus on the proliferation and differentiation of immunocompetent cells, the formation of specific antibodies, and the course of the disease in children with glomerulonephritis (GN).
Methods
The study included 45 children with glomerulonephritis (GN) aged 5 to 15 years, in remission from 6 months up to 4 years. Of these, 25 children were revaccinated with DT toxoid (Diphtheria-Tetanus toxoid with reduced antigenic content) and 20 were in the control group (not vaccinated). The frequency of development of local and systemic reactions and the course of GN were assessed. The subpopulation structure of lymphocytes was studied in dynamics after 1-6-12 months by flow cytometry and IgG levels to diphtheria and tetanus were studied by ELISA.
Results
In 92% of children with GN, the post-vaccination period was uneventful. 8% showed a rise in temperature up to 37.3
Conclusion
Revaccination with DT toxoid in children with GN not only does not cause undesirable changes in the system of immunocompetent cells but also has an immunomodulatory effect, which contributes to the favorable maintenance of the remission period of the disease.
Identifiants
pubmed: 34691025
doi: 10.3389/fimmu.2021.715389
pmc: PMC8527030
doi:
Substances chimiques
Antibodies, Bacterial
0
Immunoglobulin G
0
Tetanus Toxoid
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
715389Informations de copyright
Copyright © 2021 Kostinov, Akhmatova, Magarshak, Vlasenko, Polishchuk, Kostinova and Mashilov.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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