Role of the Tyrosine Phosphatase SHP-2 in Mediating Adrenomedullin Proangiogenic Activity in Solid Tumors.
SHP-2
adrenomedullin
angiogenesis
cell-cell adhesions
endothelial cell
glioblastoma-associated endothelial cells
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
08
2021
accepted:
14
09
2021
entrez:
25
10
2021
pubmed:
26
10
2021
medline:
26
10
2021
Statut:
epublish
Résumé
VE-cadherin is an essential adhesion molecule in endothelial adherens junctions, and the integrity of these complexes is thought to be regulated by VE-cadherin tyrosine phosphorylation. We have previously shown that adrenomedullin (AM) blockade correlates with elevated levels of phosphorylated VE-cadherin (pVE-cadherin
Identifiants
pubmed: 34692535
doi: 10.3389/fonc.2021.753244
pmc: PMC8531523
doi:
Types de publication
Journal Article
Langues
eng
Pagination
753244Informations de copyright
Copyright © 2021 Sigaud, Dussault, Berenguer-Daizé, Vellutini, Benyahia, Cayol, Parat, Mabrouk, Vázquez, Riveiro, Metellus and Ouafik.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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