A Machine Learning Approach to Investigate the Uncertainty of Tissue-Level Injury Metrics for Cerebral Contusion.

brain biomechanics cerebral contusion controlled cortical impact finite element modeling machine learning tissue-level injury criteria traumatic brain injury

Journal

Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513

Informations de publication

Date de publication:
2021
Historique:
received: 24 05 2021
accepted: 10 08 2021
entrez: 25 10 2021
pubmed: 26 10 2021
medline: 26 10 2021
Statut: epublish

Résumé

Controlled cortical impact (CCI) on porcine brain is often utilized to investigate the pathophysiology and functional outcome of focal traumatic brain injury (TBI), such as cerebral contusion (CC). Using a finite element (FE) model of the porcine brain, the localized brain strain and strain rate resulting from CCI can be computed and compared to the experimentally assessed cortical lesion. This way, tissue-level injury metrics and corresponding thresholds specific for CC can be established. However, the variability and uncertainty associated with the CCI experimental parameters contribute to the uncertainty of the provoked cortical lesion and, in turn, of the predicted injury metrics. Uncertainty quantification

Identifiants

pubmed: 34692652
doi: 10.3389/fbioe.2021.714128
pii: 714128
pmc: PMC8531645
doi:

Types de publication

Journal Article

Langues

eng

Pagination

714128

Informations de copyright

Copyright © 2021 Menichetti, Bartsoen, Depreitere, Vander Sloten and Famaey.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Andrea Menichetti (A)

Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium.

Laura Bartsoen (L)

Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium.

Bart Depreitere (B)

Neurosurgery, University Hospitals Leuven, Leuven, Belgium.

Jos Vander Sloten (J)

Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium.

Nele Famaey (N)

Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium.

Classifications MeSH