Higher cerebrospinal fluid tau is associated with history of traumatic brain injury and reduced processing speed in Vietnam-era veterans: A Department of Defense Alzheimer's Disease Neuroimaging Initiative (DOD-ADNI) study.
cerebrospinal fluid
tau
traumatic brain injury
Journal
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
03
2021
revised:
08
07
2021
accepted:
03
08
2021
entrez:
25
10
2021
pubmed:
26
10
2021
medline:
26
10
2021
Statut:
epublish
Résumé
Our goal was to determine whether cognitive and cerebrospinal fluid (CSF) markers of tau and amyloid beta 1-42 (Aβ A total of 102 male participants (52 TBI, 50 military controls [MCs]; mean age = 68) were included. Levels of CSF Aβ Relative to MCs, the TBI group showed significantly higher p-tau ( Tau accumulation may represent a mechanism of dementia risk in older veterans with remote TBI.
Identifiants
pubmed: 34692979
doi: 10.1002/dad2.12239
pii: DAD212239
pmc: PMC8515227
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12239Subventions
Organisme : CSRD VA
ID : IK2 CX001865
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062429
Pays : United States
Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
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