Brain atrophy trajectories predict differential functional performance in Alzheimer's disease: Moderations with apolipoprotein E and sex.
Alzheimer's Disease Neuroimaging Initiative
Alzheimer's disease
Sunnybrook Dementia Study
apolipoprotein E
brain parenchymal fraction
functional decline
sex
Journal
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
07
2021
accepted:
09
08
2021
entrez:
25
10
2021
pubmed:
26
10
2021
medline:
26
10
2021
Statut:
epublish
Résumé
We examine whether distinct brain atrophy patterns (using brain parenchymal fraction [BPF]) differentially predict functional performance and decline in Alzheimer's disease (AD), and are independently moderated by (1) a key AD genetic risk marker (apolipoprotein E [ We used a 2-year longitudinal sample of AD patients (baseline We observed that high brain atrophy class predicted lower functional performance and steeper decline. This association was moderated by Women
Identifiants
pubmed: 34692981
doi: 10.1002/dad2.12244
pii: DAD212244
pmc: PMC8515221
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12244Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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