Tuberculosis endotypes to guide stratified host-directed therapy.
Tuberculosis
endotypes
immune correlates of protection
Journal
Med (New York, N.Y.)
ISSN: 2666-6340
Titre abrégé: Med
Pays: United States
ID NLM: 101769215
Informations de publication
Date de publication:
12 03 2021
12 03 2021
Historique:
entrez:
25
10
2021
pubmed:
26
10
2021
medline:
26
10
2021
Statut:
ppublish
Résumé
There is hope that host-directed therapy (HDT) for Tuberculosis (TB) can either shorten treatment duration, help cure drug resistant disease or limit the immunopathology. Many candidate HDT drugs have been proposed, however solid evidence only exists for a few select patient groups. The clinical presentation of TB is variable, with differences in severity, tissue pathology, and bacillary burden. TB clinical phenotypes likely determine the potential benefit of HDT. Underlying TB clinical phenotypes, there are TB "endotypes," defined as distinct molecular profiles, with specific metabolic, epigenetic, transcriptional, and immune phenotypes. TB endotypes can be characterized by either immunodeficiency or pathologic excessive inflammation. Additional factors, like comorbidities (HIV, diabetes, helminth infection), structural lung disease or
Identifiants
pubmed: 34693385
doi: 10.1016/j.medj.2020.11.003
pmc: PMC8530349
mid: NIHMS1739847
doi:
Substances chimiques
Antitubercular Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Pagination
217-232Subventions
Organisme : NIAID NIH HHS
ID : R01 AI137527
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES027725
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI104960
Pays : United States
Organisme : NIAID NIH HHS
ID : K23 AI141681
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES030285
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA125123
Pays : United States
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