Cave Microbes as a Potential Source of Drugs Development in the Modern Era.
Antibiotic resistance
Antimicrobial drugs
Cave ecosystem
Speleotherapy
Journal
Microbial ecology
ISSN: 1432-184X
Titre abrégé: Microb Ecol
Pays: United States
ID NLM: 7500663
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
20
07
2021
accepted:
29
09
2021
pubmed:
26
10
2021
medline:
3
11
2022
entrez:
25
10
2021
Statut:
ppublish
Résumé
The world is constantly facing threats, including the emergence of new pathogens and antibiotic resistance among extant pathogens, which is a matter of concern. Therefore, the need for natural and effective sources of drugs is inevitable. The ancient and pristine ecosystems of caves contain a unique microbial world and could provide a possible source of antimicrobial metabolites. The association between humans and caves is as old as human history itself. Historically, cave environments have been used to treat patients with respiratory tract infections, which is referred to as speleotherapy. Today, the pristine environment of caves that comprise a poorly explored microbial world is a potential source of antimicrobial and anticancer drugs. Oligotrophic conditions in caves enhance the competition among microbial communities, and unique antimicrobial agents may be used in this competition. This review suggests that the world needs a novel and effective source of drug discovery. Therefore, being the emerging spot of modern human civilization, caves could play a crucial role in the current medical crisis, and cave microorganisms may have the potential to produce novel antimicrobial and anticancer drugs.
Identifiants
pubmed: 34693460
doi: 10.1007/s00248-021-01889-3
pii: 10.1007/s00248-021-01889-3
pmc: PMC8542507
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
676-687Subventions
Organisme : national natural science foundation of china
ID : 32070113
Organisme : guangdong science and technology department
ID : 2019ST023
Organisme : pifi fellowship from the chinese academy of sciences
ID : 2020PC0052
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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