Sepsis in Pediatric Cancer: Does Gender Matter? A 20-Year Retrospective Study.
BSI
Childhood cancer
Sex disparity
Journal
Infectious diseases and therapy
ISSN: 2193-8229
Titre abrégé: Infect Dis Ther
Pays: New Zealand
ID NLM: 101634499
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
19
08
2021
accepted:
08
10
2021
pubmed:
26
10
2021
medline:
26
10
2021
entrez:
25
10
2021
Statut:
ppublish
Résumé
Gender plays an active role in the incidence and outcome of many infectious and malignant diseases. However, there is still no study examining sex differences for developing bloodstream infections (BSIs) in pediatric patients with cancer. We sought to identify potential gender-specific risk factors for BSIs. Data were retrospectively analyzed from 621 pediatric patients treated for childhood cancer in a tertiary single center between 1 January 2000 and 31 June 2018. After central venous access device (CVAD) placement, patients were followed up until CVAD was removed or at the most for 1 year. We calculated the gender-specific prevalence for BSIs and compared the causative bacterial strains. Of 621 pediatric patients with cancer (283 girls [45.6%] and 338 boys [54.4%]), 110 patients (41 girls [37.3%] and 69 boys [62.7%]) were identified with a total of 134 BSIs. Girls and boys had a similar incidence for BSI (13%) within the first 3 months of therapy, after which the risk for BSI increased significantly for boys (34% versus 21%, boys versus girls, P = 0.025). Moreover, BSI with gram-positive bacteria affected boys nearly twice as often as girls (29.8% versus 56.5%, girls versus boys). Future clinical awareness of hygiene-related BSIs in boys could be helpful in identifying areas for improvement.
Identifiants
pubmed: 34694580
doi: 10.1007/s40121-021-00549-w
pii: 10.1007/s40121-021-00549-w
pmc: PMC8847481
doi:
Types de publication
Journal Article
Langues
eng
Pagination
581-585Informations de copyright
© 2021. The Author(s).
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