Nephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin-induced diabetic nephropathy rats.
Journal
IET nanobiotechnology
ISSN: 1751-875X
Titre abrégé: IET Nanobiotechnol
Pays: United States
ID NLM: 101303205
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
revised:
05
01
2021
received:
01
10
2020
accepted:
25
01
2021
entrez:
25
10
2021
pubmed:
26
10
2021
medline:
26
11
2021
Statut:
ppublish
Résumé
Currently, the field of nanomedicine, which uses active compounds from medicinal plants, has emerged as a therapy for diabetic nephropathy. From this study, the renoprotective effect of TC-loaded PLA Nanoparticles (TC-PLA NPs) on streptozotocin (STZ)-induced diabetic nephropathy rats was investigated. The results showed that the nephroprotective effect of TC-PLA NPs reduces the blood glucose level, regulates the renal parameters, decreases the cytokine levels and reduces the mRNA expressions level of different genes related to diabetic nephropathy.
Identifiants
pubmed: 34694717
doi: 10.1049/nbt2.12030
pmc: PMC8675778
doi:
Substances chimiques
Plant Extracts
0
Polyesters
0
poly(lactide)
459TN2L5F5
Streptozocin
5W494URQ81
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
411-417Informations de copyright
© 2021 The Authors. IET Nanobiotechnology published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology.
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