SnoRNAs and miRNAs Networks Underlying COVID-19 Disease Severity.
COVID-19
SARS-CoV-2
biomarkers
miRNA
snoRNA
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
23 Sep 2021
23 Sep 2021
Historique:
received:
03
08
2021
revised:
15
09
2021
accepted:
19
09
2021
entrez:
26
10
2021
pubmed:
27
10
2021
medline:
27
10
2021
Statut:
epublish
Résumé
There is a lack of predictive markers for early and rapid identification of disease progression in COVID-19 patients. Our study aims at identifying microRNAs (miRNAs)/small nucleolar RNAs (snoRNAs) as potential biomarkers of COVID-19 severity. Using differential expression analysis of microarray data (n = 29), we identified hsa-miR-1246, ACA40, hsa-miR-4532, hsa-miR-145-5p, and ACA18 as the top five differentially expressed transcripts in severe versus asymptomatic, and ACA40, hsa-miR-3609, ENSG00000212378 (SNORD78), hsa-miR-1231, hsa-miR-885-3p as the most significant five in severe versus mild cases. Moreover, we found that white blood cell (WBC) count, absolute neutrophil count (ANC), neutrophil (%), lymphocyte (%), red blood cell (RBC) count, hemoglobin, hematocrit, D-Dimer, and albumin are significantly correlated with the identified differentially expressed miRNAs and snoRNAs. We report a unique miRNA and snoRNA profile that is associated with a higher risk of severity in a cohort of SARS-CoV-2 infected patients. Altogether, we present a differential expression analysis of COVID-19-associated microRNA (miRNA)/small nucleolar RNA (snoRNA) signature, highlighting their importance in SARS-CoV-2 infection.
Identifiants
pubmed: 34696164
pii: vaccines9101056
doi: 10.3390/vaccines9101056
pmc: PMC8538251
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Qatar University
ID : QUST-1-CMED-2021-2
Références
Nat Commun. 2021 Mar 30;12(1):1961
pubmed: 33785765
Genes (Basel). 2020 Nov 16;11(11):
pubmed: 33207533
J Hematol Oncol. 2020 Jun 3;13(1):64
pubmed: 32493414
Nucleic Acids Res. 2014;42(17):e133
pubmed: 25063298
Nucleic Acids Res. 2020 Jan 8;48(D1):D148-D154
pubmed: 31647101
Bioinformatics. 2010 Oct 1;26(19):2363-7
pubmed: 20688976
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Mol Biol Res Commun. 2020 Jun;9(2):83-91
pubmed: 32802902
Bioinformatics. 2017 Feb 15;33(4):592-593
pubmed: 27797767
Nat Methods. 2015 Feb;12(2):115-21
pubmed: 25633503
Nucleic Acids Res. 2020 Feb 28;48(4):1627-1651
pubmed: 31828325
Noncoding RNA Res. 2020 Dec;5(4):222-231
pubmed: 33251388
J Clin Invest. 2020 May 1;130(5):2620-2629
pubmed: 32217835
PLoS Pathog. 2009 Aug;5(8):e1000547
pubmed: 19680535
Viruses. 2018 Aug 19;10(8):
pubmed: 30126238
Heliyon. 2021 May;7(5):e06866
pubmed: 33898797
Bioinformatics. 2011 Jun 15;27(12):1739-40
pubmed: 21546393
BMC Bioinformatics. 2019 Nov 4;20(1):545
pubmed: 31684860
Front Genet. 2020 Jul 10;11:765
pubmed: 32765592
PLoS One. 2020 Jul 29;15(7):e0235987
pubmed: 32726325
Front Genet. 2018 Oct 02;9:439
pubmed: 30333857
Noncoding RNA Res. 2019 Feb 14;4(2):46-53
pubmed: 31193534
Exp Mol Med. 2021 May;53(5):750-760
pubmed: 33953323
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Antiviral Res. 2020 Jun;178:104787
pubmed: 32251768
Infect Genet Evol. 2021 Jul;91:104832
pubmed: 33812037
Front Cell Dev Biol. 2020 Mar 10;8:143
pubmed: 32211411
Drugs. 2021 Apr;81(5):517-531
pubmed: 33638807
Front Immunol. 2017 Sep 25;8:1182
pubmed: 28993774
Aging Dis. 2020 May 9;11(3):509-522
pubmed: 32489698
Brief Bioinform. 2021 Mar 22;22(2):1137-1149
pubmed: 33675361
Clin Transl Med. 2020 Oct;10(6):e200
pubmed: 33135345
Cell. 2004 Jan 23;116(2):281-97
pubmed: 14744438
Transl Res. 2021 Oct;236:147-159
pubmed: 34048985
Noncoding RNA. 2021 Feb 18;7(1):
pubmed: 33670580
Viruses. 2020 Dec 01;12(12):
pubmed: 33271762