The Clinical Relevance of the Microbiome in Hidradenitis Suppurativa: A Systematic Review.

hidradenitis suppurativa microbiome

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
25 Sep 2021
Historique:
received: 20 08 2021
revised: 18 09 2021
accepted: 20 09 2021
entrez: 26 10 2021
pubmed: 27 10 2021
medline: 27 10 2021
Statut: epublish

Résumé

Hidradenitis suppurativa is a chronic disease of the pilosebaceous unit. The name of the condition is a testament to the presumed relationship between the disease and the microbiome. The pathophysiology of hidradenitis suppurativa is, however, complex and believed to be the product of a multifactorial interplay between the interfollicular epithelium, pilosebaceous unit, microbiome, as well as genetic and environmental factors. In this review we assimilate the existing literature regarding the role played by the human microbiome in HS in various contexts of the disease, including the pathophysiologic, therapeutic, and potentially, diagnostic as well prognostic. In conclusion, the role played by the microbiome in HS is extensive and relevant and can have bench-to-bedside applications.

Identifiants

pubmed: 34696185
pii: vaccines9101076
doi: 10.3390/vaccines9101076
pmc: PMC8537933
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Références

Nat Microbiol. 2016 Feb 01;1:15032
pubmed: 27572438
Surgery. 2020 Jun;167(6):1012-1015
pubmed: 32098690
Diseases. 2018 Jun 02;6(2):
pubmed: 29865237
Exp Dermatol. 2019 Mar;28(3):312-316
pubmed: 30657613
Clin Exp Dermatol. 2019 Dec;44(8):882-892
pubmed: 30828847
Am J Hum Biol. 2022 Jan;34(1):e23584
pubmed: 33644952
J Allergy Clin Immunol. 2016 Mar;137(3):852-60
pubmed: 26431583
Nat Rev Microbiol. 2018 Mar;16(3):143-155
pubmed: 29332945
Nature. 2012 Jun 13;486(7402):207-14
pubmed: 22699609
Surgery. 2013 Nov;154(5):1126-30
pubmed: 23891479
J Gen Microbiol. 1993 Aug;139(8):1745-51
pubmed: 8409917
Science. 2004 Jul 30;305(5684):671-3
pubmed: 15286373
mBio. 2020 Feb 18;11(1):
pubmed: 32071266
Infection. 2016 Apr;44(2):247-9
pubmed: 26129687
J Allergy Clin Immunol. 2015 Jan;135(1):25-30
pubmed: 25567040
Science. 2013 Jul 5;341(6141):1237439
pubmed: 23828941
J Am Acad Dermatol. 1999 Jan;40(1):73-6
pubmed: 9922015
Int J Dermatol. 2005 Jul;44(7):535-40
pubmed: 15985019
Dermatol Online J. 2006 Dec 10;12(7):6
pubmed: 17459292
J Invest Dermatol. 2013 Sep;133(9):2152-60
pubmed: 23337890
Science. 2009 May 29;324(5931):1190-2
pubmed: 19478181
Allergy Asthma Immunol Res. 2018 Jul;10(4):354-362
pubmed: 29949831
J Eur Acad Dermatol Venereol. 2019 Jan;33(1):170-177
pubmed: 30022542
Science. 2012 Aug 31;337(6098):1115-9
pubmed: 22837383
Br J Dermatol. 1999 Jan;140(1):90-5
pubmed: 10215774
Acta Derm Venereol. 2017 Apr 6;97(4):493-498
pubmed: 27882387
Inflamm Bowel Dis. 2012 Sep;18(9):1743-8
pubmed: 22275320
Microbiome. 2017 Mar 3;5(1):27
pubmed: 28253908
Nat Rev Immunol. 2016 May 27;16(6):353-66
pubmed: 27231051
Brain Behav Immun. 2015 Aug;48:186-94
pubmed: 25882912
Dermatol Ther. 2019 Sep;32(5):e13044
pubmed: 31364786
JAMA Dermatol. 2017 Sep 1;153(9):897-905
pubmed: 28538949
Exp Dermatol. 2019 Nov;28(11):1210-1218
pubmed: 31386766
Int J Dermatol. 2022 Oct;61(10):1175-1186
pubmed: 34530487
Br J Dermatol. 2017 Apr;176(4):993-1000
pubmed: 27564400
PLoS One. 2010 Aug 19;5(8):e12277
pubmed: 20808860
Nature. 2010 Mar 4;464(7285):59-65
pubmed: 20203603
J Am Acad Dermatol. 2015 Nov;73(5 Suppl 1):S66-9
pubmed: 26470620
Arch Dermatol Res. 2020 Mar;312(2):159-163
pubmed: 31422449
Microbiome. 2019 Feb 11;7(1):18
pubmed: 30744677
Front Immunol. 2018 Oct 16;9:2379
pubmed: 30459758
APMIS. 2014 Sep;122(9):804-9
pubmed: 24475943
J Eur Acad Dermatol Venereol. 2018 May;32(5):e195-e196
pubmed: 29178657
Appl Microbiol Biotechnol. 2014 Feb;98(4):1531-7
pubmed: 24384749
J Eur Acad Dermatol Venereol. 2021 Apr;35(4):e251-e254
pubmed: 33007126
Science. 2015 Apr 3;348(6230):80-6
pubmed: 25838377
Nat Microbiol. 2016 Jul 11;1(9):16106
pubmed: 27562258
Nat Rev Immunol. 2012 Jun 25;12(7):503-16
pubmed: 22728527
J Am Acad Dermatol. 2010 Apr;62(4):706-8, 708.e1
pubmed: 20227585
Science. 2014 Nov 21;346(6212):954-9
pubmed: 25414304
J Invest Dermatol. 2021 Jan;141(1):225-228.e2
pubmed: 32422215
Acta Derm Venereol. 2014 Sep;94(5):553-7
pubmed: 24577555
J Invest Dermatol. 2020 Sep;140(9):1847-1855.e6
pubmed: 32339539
Nature. 2013 Jun 20;498(7454):367-70
pubmed: 23698366
J Allergy Clin Immunol. 2020 Aug;146(2):452-455.e5
pubmed: 32061710
J Am Acad Dermatol. 2019 Mar;80(3):821-822
pubmed: 30403961
J Eur Acad Dermatol Venereol. 2019 May;33(5):930-936
pubmed: 30394587
J Allergy Clin Immunol. 2017 Jan;139(1):166-172
pubmed: 27609659
Emerg Infect Dis. 2014 Dec;20(12):1990-8
pubmed: 25418454
Br J Dermatol. 2017 Jan;176(1):241-243
pubmed: 27291084
J Allergy Clin Immunol. 2020 Jan;145(1):93-96
pubmed: 31910987
Dermatology. 2005;211(3):193-8
pubmed: 16205063
Sci Transl Med. 2017 Jul 5;9(397):
pubmed: 28679656
Cell. 2016 May 5;165(4):854-66
pubmed: 27153496
Eur J Clin Microbiol Infect Dis. 2021 Jan;40(1):77-83
pubmed: 32767177
JAAD Case Rep. 2021 Feb 02;9:86-89
pubmed: 33665286
Dermatology. 2021;237(1):81-96
pubmed: 31645040
Nat Methods. 2016 May;13(5):435-8
pubmed: 26999001
J Am Acad Dermatol. 2015 Nov;73(5 Suppl 1):S12-8
pubmed: 26470608
Australas J Dermatol. 2020 Nov;61(4):307-311
pubmed: 32761824
Front Microbiol. 2018 Oct 02;9:2362
pubmed: 30333815
Front Immunol. 2019 Feb 12;10:204
pubmed: 30809226
Microbiome. 2015 Jul 30;3:31
pubmed: 26229597
mBio. 2015 Oct 20;6(5):e01578-15
pubmed: 26489866
Front Microbiol. 2018 Jul 10;9:1459
pubmed: 30042740
Br J Dermatol. 2019 Nov;181(5):1038-1045
pubmed: 30829398
Clin Case Rep. 2020 Feb 06;8(3):504-507
pubmed: 32185045
Nat Rev Microbiol. 2015 Jun;13(6):360-72
pubmed: 25915636
EBioMedicine. 2020 Jan;51:102590
pubmed: 31901868
J Allergy Clin Immunol. 2020 Aug;146(2):461
pubmed: 32482529
Dermatology. 2006;213(4):305-12
pubmed: 17135736
J Eur Acad Dermatol Venereol. 2019 Sep;33(9):1775-1780
pubmed: 30908704
J Eur Acad Dermatol Venereol. 2018 Jan;32(1):125-128
pubmed: 28833590
Anaerobe. 2017 Feb;43:43-46
pubmed: 27913316
Acta Derm Venereol. 2017 Feb 8;97(2):208-213
pubmed: 27377144
Gut. 2014 Sep;63(9):1513-21
pubmed: 24833634
J Invest Dermatol. 2017 Mar;137(3):561-568
pubmed: 28063650
BMC Obes. 2017 Jul 17;4:28
pubmed: 28725447
Sci Rep. 2019 Nov 21;9(1):17287
pubmed: 31754146
Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6241-6
pubmed: 22454494
PLoS One. 2016 Feb 05;11(2):e0148028
pubmed: 26849217
Nature. 2007 Oct 18;449(7164):804-10
pubmed: 17943116
JAMA Dermatol. 2016 Nov 1;152(11):1276-1278
pubmed: 27438914
Immunity. 2015 Nov 17;43(5):1011-21
pubmed: 26588783
Dermatology. 2021;237(3):372-377
pubmed: 33401280
J Crohns Colitis. 2016 Sep;10(9):1067-75
pubmed: 26971052
Clin Exp Dermatol. 2019 Oct;44(7):777-780
pubmed: 30719727
Front Immunol. 2020 Aug 19;11:1730
pubmed: 32973741
PLoS One. 2019 May 6;14(5):e0216249
pubmed: 31059533
Gut. 2006 Aug;55(8):1207
pubmed: 16849351
Exp Dermatol. 2020 Dec;29(12):1154-1170
pubmed: 33058306
Nat Rev Microbiol. 2011 Apr;9(4):244-53
pubmed: 21407241
Clin Exp Dermatol. 2022 Jan;47(1):139-141
pubmed: 34236727
Nat Immunol. 2005 Jan;6(1):57-64
pubmed: 15568027
JAAD Case Rep. 2019 Jun 08;5(6):525-528
pubmed: 31205996
Dis Markers. 2018 Jan 28;2018:5823684
pubmed: 29619128
Nature. 2015 Jul 9;523(7559):208-11
pubmed: 26083755
Am J Clin Dermatol. 2019 Dec;20(6):749-761
pubmed: 31444782
Nat Immunol. 2001 Dec;2(12):1133-7
pubmed: 11694882
Ther Adv Chronic Dis. 2019 Mar 01;10:2040622319830646
pubmed: 30854183
J Dermatolog Treat. 2021 Jun;32(4):473-475
pubmed: 31535587
Br J Dermatol. 2020 Aug;183(2):387-389
pubmed: 32078163
J Dermatolog Treat. 2018 Mar;29(2):202-207
pubmed: 28749746
J Eur Acad Dermatol Venereol. 2019 Jun;33(6):e248-e250
pubmed: 30801776
Int J Surg Case Rep. 2019;55:50-53
pubmed: 30685629
J Invest Dermatol. 1971 Feb;56(2):127-31
pubmed: 4997367
J Invest Dermatol. 2020 Sep;140(9):1688-1690
pubmed: 32800181
Front Microbiol. 2020 Dec 15;11:589726
pubmed: 33384669
Proc Natl Acad Sci U S A. 2012 May 22;109(21):8334-9
pubmed: 22566627
J Invest Dermatol. 2020 Jul;140(7):1473-1476
pubmed: 31838125
Immunity. 2017 Apr 18;46(4):562-576
pubmed: 28423337
Curr Opin HIV AIDS. 2010 Nov;5(6):463-6
pubmed: 20978388
Dermatol Ther. 2018 Nov;31(6):e12715
pubmed: 30397984
J Allergy Clin Immunol. 2020 Aug;146(2):461-462
pubmed: 32482528
J Dermatol Sci. 2021 Mar;101(3):218-220
pubmed: 33423845
Evol Med Public Health. 2020 Feb 19;2020(1):45-46
pubmed: 32190327
Am J Clin Dermatol. 2020 Sep;21(Suppl 1):18-24
pubmed: 32910436
Brief Bioinform. 2019 Jul 19;20(4):1125-1136
pubmed: 29028872
Cell. 2016 Jan 28;164(3):337-40
pubmed: 26824647
Cell Host Microbe. 2014 Mar 12;15(3):382-392
pubmed: 24629344
Dermatology. 2020;236(1):46-51
pubmed: 31141811
Mediators Inflamm. 2017;2017:9474896
pubmed: 28316379
Cutis. 2005 Apr;75(4 Suppl):6-11
pubmed: 15916224
Int J Mol Sci. 2019 Jul 12;20(14):
pubmed: 31336824
Cell Host Microbe. 2014 Sep 10;16(3):276-89
pubmed: 25211071
BMC Biol. 2014 Nov 12;12:87
pubmed: 25387460
Nature. 2014 Oct 2;514(7520):59-64
pubmed: 25279917
J Invest Dermatol. 2020 Apr;140(4):922-925.e3
pubmed: 31539533

Auteurs

Dillon Mintoff (D)

Department of Pathology, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, Malta.
Department of Dermatology, Mater Dei Hospital, Triq Id-Donaturi tad-Demm, MSD 2090 Msida, Malta.

Isabella Borg (I)

Department of Pathology, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, Malta.
Centre for Molecular Medicine and Biobanking, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, Malta.
Medical Genetics Unit, Department of Pathology, Mater Dei Hospital, MSD 2090 Msida, Malta.

Nikolai Paul Pace (NP)

Centre for Molecular Medicine and Biobanking, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, Malta.

Classifications MeSH