Emergency FMD Serotype O Vaccines Protect Cattle against Heterologous Challenge with a Variant Foot-and-Mouth Disease Virus from the O/ME-SA/Ind2001 Lineage.

cattle foot-and-mouth disease virus heterologous challenge serotype O/ME-SA/Ind2001 variant vaccine efficacy

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
29 Sep 2021
Historique:
received: 21 08 2021
revised: 21 09 2021
accepted: 21 09 2021
entrez: 26 10 2021
pubmed: 27 10 2021
medline: 27 10 2021
Statut: epublish

Résumé

Vaccination is one of the best approaches to control and eradicate foot-and-mouth disease (FMD). To achieve this goal, vaccines with inactivated FMD virus antigen in suitable adjuvants are being used in addition to other control measures. However, only a limited number of vaccine strains are commercially available, which often have a restricted spectrum of activity against the different FMD virus strains in circulation. As a result, when new strains emerge, it is important to measure the efficacy of the current vaccine strains against these new variants. This is important for countries where FMD is endemic but also for countries that hold an FMD vaccine bank, to ensure they are prepared for emergency vaccination. The emergence and spread of the O/ME-SA/Ind-2001 lineage of viruses posed a serious threat to countries with OIE-endorsed FMD control plans who had not reported FMD for many years. In vitro vaccine-matching results showed a poor match (r

Identifiants

pubmed: 34696216
pii: vaccines9101110
doi: 10.3390/vaccines9101110
pmc: PMC8537456
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Meat and Livestock Australia
ID : P.PSH.0779
Organisme : Department of Agriculture, Water and the Environment
ID : RRND4P-15-02-032

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Auteurs

Nagendrakumar Balasubramanian Singanallur (NB)

Australian Centre for Disease Preparedness, CSIRO-Health & Biosecurity, 5 Portarlington Road, Geelong, VIC 3220, Australia.

Aldo Dekker (A)

Laboratory Vesicular Diseases, Department of Virology and Molecular Biology, Wageningen Bioveterinary Research, Houtribweg 39, 8221 RA Lelystad, The Netherlands.

Phaedra Lydia Eblé (PL)

Laboratory Vesicular Diseases, Department of Virology and Molecular Biology, Wageningen Bioveterinary Research, Houtribweg 39, 8221 RA Lelystad, The Netherlands.

Froukje van Hemert-Kluitenberg (F)

Laboratory Vesicular Diseases, Department of Virology and Molecular Biology, Wageningen Bioveterinary Research, Houtribweg 39, 8221 RA Lelystad, The Netherlands.

Klaas Weerdmeester (K)

Laboratory Vesicular Diseases, Department of Virology and Molecular Biology, Wageningen Bioveterinary Research, Houtribweg 39, 8221 RA Lelystad, The Netherlands.

Jacquelyn J Horsington (JJ)

Australian Centre for Disease Preparedness, CSIRO-Health & Biosecurity, 5 Portarlington Road, Geelong, VIC 3220, Australia.

Wilna Vosloo (W)

Australian Centre for Disease Preparedness, CSIRO-Health & Biosecurity, 5 Portarlington Road, Geelong, VIC 3220, Australia.

Classifications MeSH