Enemy of My Enemy: A Novel Insect-Specific Flavivirus Offers a Promising Platform for a Zika Virus Vaccine.
Zika virus
correlates of protection
flavivirus
insect-specific virus
vaccine
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
07 Oct 2021
07 Oct 2021
Historique:
received:
25
08
2021
revised:
25
09
2021
accepted:
30
09
2021
entrez:
26
10
2021
pubmed:
27
10
2021
medline:
27
10
2021
Statut:
epublish
Résumé
Vaccination remains critical for viral disease outbreak prevention and control, but conventional vaccine development typically involves trade-offs between safety and immunogenicity. We used a recently discovered insect-specific flavivirus as a vector in order to develop an exceptionally safe, flavivirus vaccine candidate with single-dose efficacy. To evaluate the safety and efficacy of this platform, we created a chimeric Zika virus (ZIKV) vaccine candidate, designated Aripo/Zika virus (ARPV/ZIKV). ZIKV has caused immense economic and public health impacts throughout the Americas and remains a significant public health threat. ARPV/ZIKV vaccination showed exceptional safety due to ARPV/ZIKV's inherent vertebrate host-restriction. ARPV/ZIKV showed no evidence of replication or translation in vitro and showed no hematological, histological or pathogenic effects in vivo. A single-dose immunization with ARPV/ZIKV induced rapid and robust neutralizing antibody and cellular responses, which offered complete protection against ZIKV-induced morbidity, mortality and in utero transmission in immune-competent and -compromised murine models. Splenocytes derived from vaccinated mice demonstrated significant CD4
Identifiants
pubmed: 34696250
pii: vaccines9101142
doi: 10.3390/vaccines9101142
pmc: PMC8539214
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIAID NIH HHS
ID : K22 AI125474
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI153433
Pays : United States
Organisme : NIH HHS
ID : K22AI125474; R01AI153433; R03AI151494; R24AI120942
Pays : United States
Organisme : NIAID NIH HHS
ID : R03 AI151494
Pays : United States
Organisme : NIAID NIH HHS
ID : R24 AI120942
Pays : United States
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