Gag-Gag Interactions Are Insufficient to Fully Stabilize and Order the Immature HIV Gag Lattice.
HIV
immature lattice
lattice dynamics
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
28 09 2021
28 09 2021
Historique:
received:
01
09
2021
revised:
24
09
2021
accepted:
24
09
2021
entrez:
26
10
2021
pubmed:
27
10
2021
medline:
10
2
2022
Statut:
epublish
Résumé
Immature HIV virions harbor a lattice of Gag molecules with significant ordering in CA-NTD, CA-CTD and SP1 regions. This ordering plays a major role during HIV maturation. To test the condition in which the Gag lattice forms in vivo, we assembled virus like particles (VLPs) by expressing only HIV Gag in mammalian cells. Here we show that these VLPs incorporate a similar number of Gag molecules compared to immature HIV virions. However, within these VLPs, Gag molecules diffuse with a pseudo-diffusion rate of 10 nm
Identifiants
pubmed: 34696376
pii: v13101946
doi: 10.3390/v13101946
pmc: PMC8540168
pii:
doi:
Substances chimiques
gag Gene Products, Human Immunodeficiency Virus
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI150474
Pays : United States
Organisme : NIH HHS
ID : R01 AI150474
Pays : United States
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